Oxygen free radicals and human disease

Martínez-Cayuela, Marina

doi:10.1016/0300-9084(96)88119-3

Cited by 321 publications

(183 citation statements)

References 194 publications

Supporting

Mentioning

170

Contrasting

Unclassified

Order By: Relevance

“…E-mail mgiron@goliat.ugr.es antioxidant defense against free radicals are: Superoxide Dismutase (SOD) and Catalase (CAT) [3,5]. SODs catalyse the dismutation of superoxide radical to produce hydrogen peroxide and molecular oxygen [9]. CAT has been reported to be responsible for the detoxification of hydrogen peroxide [9,10].…”

Section: Introductionmentioning

confidence: 99%

Modulation of hepatic and intestinal Glutathione S-transferases and other antioxidant enzymes by dietary lipids in streptozotocin diabetic rats

et al. 1999

View full text Add to dashboard Cite

Antioxidant enzymes in liver and small intestine were investigated using control and streptozotocin diabetic rats fed diets with 5% olive, sunflower or fish oil for five weeks. In liver, GlutathionePeroxidase and Superoxide Dismutase decreased and in intestine Glutathione-S-transferase (GST) increased by diabetes. In isolated jejunum and ileum, this increase in GST activity was due to an increase in GST-a and -~t isoenzymes in jejunum and GST-~, la and -re in ileum. Since GST plays an important role in protecting tissues from oxidative damage, our results highlight the role of the intestine against free radicals in physiological or pathological situations.

show abstract

Section: Introductionmentioning

confidence: 99%

Modulation of hepatic and intestinal Glutathione S-transferases and other antioxidant enzymes by dietary lipids in streptozotocin diabetic rats

et al. 1999

View full text Add to dashboard Cite

show abstract

“…Food antioxidants are useful tools to prevent the negative effects of free radicals in the human body, which may lead to a reduction of the risk of some chronic diseases related to the redox state of the human body [1,2]. The food industry has widely used antioxidants to extend the shelf life of food products.…”

Section: Introductionmentioning

confidence: 99%

Wild blackthorn (Prunus spinosaL.) and hawthorn (Crataegus monogynaJacq.) fruits as valuable sources of antioxidants

Ruiz‐Rodríguez¹,

Ancos

Sánchez‐Moreno

et al. 2014

Fruits

View full text Add to dashboard Cite

Wild blackthorn (Prunus spinosa L.) and hawthorn (Crataegus monogyna Jacq.) fruits as valuable sources of antioxidants.Abstract -Introduction. Many underutilized wild fruits have great nutritional and functional potential, providing chemical compounds with biological properties. Materials and methods. In the present work we quantified bioactive compounds such as vitamin C (ascorbic and dehydroascorbic acids), and total phenolic compounds composed mainly of phenolic acids, flavonols and anthocyanins, as well as evaluating the antioxidant capacity through different in vitro tests (Folin-Ciocalteu, ABTS ·+ , DPPH · and FRAP) in wild blackthorn (P. spinosa L.) and hawthorn (C. monogyna Jacq.) fruits of Spanish origin, including samples from different seasons and locations. Results and discussion. As expected, wide variability was found in the composition of fruits of the same species, which justifies the necessity of analyzing several batches of wild fruits, in order to have representative results taking into account the natural variability. Fruits of P. spinosa showed vitamin C content ranging between (5.14 and 15.35) mg·100 g -1 fw (mainly dehydroascorbic acid); total phenolic compounds ranged from (1851 to 3825) mg·100 g -1 fw, characterized by a high content of anthocyanins and phenolic acids. Fruits of C. monogyna presented (16 to 39) mg vitamin C·100 g -1 fw and (449 to 1438) mg total phenolic compounds·100 g -1 fw, characterized by a high content of phenolic acids and flavonols. Antioxidant capacity was higher for P. spinosa fruits than for C. monogyna fruits; DPPH · values showed a strong correlation with vitamin C, while phenolic compounds were a major contributor to the antioxidant activity of these fruit extracts. Fruits of P. spinosa and C. monogyna should be reconsidered as new valuable sources of safe and inexpensive antioxidants. Résumé -Introduction. Beaucoup de fruits d'espèces sauvages sous-utilisées ont un grand potentiel nutritionnel et fonctionnel car ils offrent des composés chimiques présentant des propriétés biologiques. Matériel et méthodes. Dans notre travail, nous avons quantifié les composés bioactifs tels que la vitamine C (acide ascorbique et acide déhydroascorbique), les composés totaux phénoliques constitués principalement par des acides phénoliques, des flavonols et des anthocyanines, et nous avons évalué la capacité antioxydante à l'aide de différents tests in vitro (FolinCiocalteu, ABTS ·+ , DPPH · , et FRAP) dans des fruits du prunellier sauvage (P. spinosa L.) et de l'aubépine (C. monogyna Jacq.) d'origine espagnole, à partir d'échantillons de différentes saisons et lieux. Résultats et discussion. Comme prévu, la composition des fruits d'une même espèce a présenté une grande variabilité ce qui a justifié d'analyser plusieurs lots de fruits sauvages, afin de disposer de résultats représentatifs tenant compte de la variabilité naturelle. Les fruits de P. spinosa ont montré une teneur en vitamine C comprise entre (5.14 et 15.35) mg·100 g -1 mf (principalement constituée d'acide déhy...

show abstract

“…2 ), hydroxyl radicals (OH †), and hydrogen peroxide (H 2 O 2 ), are generated as by-products of aerobic metabolism as well as from a number of other sources. These ROS display varying reactivities toward different targets but share the ability to damage cells by oxidizing proteins, lipids, and DNA (Martinez-Cayuela 1995). The ability of ROS to mutate DNA and to damage cells raised the possibility that cellular aging and cancer initiation reflect accumulated ROS damage over time (Harman 1956).…”

mentioning

confidence: 99%

Cancer, Oxidative Stress, and Metastasis

Gill

Piskounova

Morrison

2016

Cold Spring Harb Symp Quant Biol

231

164

View full text Add to dashboard Cite

Reactive oxygen species (ROS) are highly reactive molecules that arise from a number of cellular sources, including oxidative metabolism in mitochondria. At low levels they can be advantageous to cells, activating signaling pathways that promote proliferation or survival. At higher levels, ROS can damage or kill cells by oxidizing proteins, lipids, and nucleic acids. It was hypothesized that antioxidants might benefit high-risk patients by reducing the rate of ROS-induced mutations and delaying cancer initiation. However, dietary supplementation with antioxidants has generally proven ineffective or detrimental in clinical trials. High ROS levels limit cancer cell survival during certain windows of cancer initiation and progression. During these periods, dietary supplementation with antioxidants may promote cancer cell survival and cancer progression. This raises the possibility that rather than treating cancer patients with antioxidants, they should be treated with pro-oxidants that exacerbate oxidative stress or block metabolic adaptations that confer oxidative stress resistance.

show abstract

Oxygen free radicals and human disease

Cited by 321 publications

References 194 publications

Modulation of hepatic and intestinal Glutathione S-transferases and other antioxidant enzymes by dietary lipids in streptozotocin diabetic rats

Modulation of hepatic and intestinal Glutathione S-transferases and other antioxidant enzymes by dietary lipids in streptozotocin diabetic rats

Wild blackthorn (Prunus spinosaL.) and hawthorn (Crataegus monogynaJacq.) fruits as valuable sources of antioxidants

Cancer, Oxidative Stress, and Metastasis

Contact Info

Product

Resources

About