Oxygen Free Radicals and Platelet and Granulocyte Aggregability in Renal Transplant Patients

Taylor, Joanne E.; Scott, N.; Hill, Alexander J.; Bridges, A. B.; Henderson, I.A.; Stewart, W. K.; Belch, J J F

doi:10.1097/00007890-199303000-00009

Cited by 48 publications

(21 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As there are no established normal values for SH and TBARS concentrations in humans, we compared our results with data obtained in healthy controls by Taylor et al [25] and McMurray et al [26]. The ranges quoted by both authors were comparable with ranges obtained in the present study.…”

Section: Discussionsupporting

confidence: 88%

The Dynamics of the Oxidant-Antioxidant Balance in the Early Phase of Human Acute Biliary Pancreatitis

et al. 2004

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 88%

The Dynamics of the Oxidant-Antioxidant Balance in the Early Phase of Human Acute Biliary Pancreatitis

et al. 2004

View full text Add to dashboard Cite

“…Restoration of renal functions after the transplantation is expected to improve the oxidative stress. However, the reports so far are controversial, mentioning both increased and decreased oxidative stress in the posttransplantation period [3, 4]. The selection criteria for the patients may be the main reason for this inconsistency.…”

Section: Discussionmentioning

confidence: 99%

“…However, the reports on how transplantation affects the oxidative state are controversial. Some reports imply that the oxidative stress related to CRF is decreased after renal transplantation [3], while the others have indicated increased free radicals [4]. …”

Section: Introductionmentioning

confidence: 99%

Assessment of Oxidative Stress in the Early Posttransplant Period: Comparison of Cyclosporine A and Tacrolimus-Based Regimens

et al. 2005

View full text Add to dashboard Cite

Background: Oxidative stress is one of the leading causes of cardiovascular morbidity and mortality in chronic kidney disease. Although it is clear that many metabolic abnormalities improve, the effects of kidney transplantation on oxidative state are obscure. Methods: Twenty-three kidney transplant patients were included in the study. Eleven patients (mean age 27.9± 9.1 years) were treated with cyclosporine A (CsA) whereas 12 patients (mean age 22.4 ± 3.4 years) were treated with tacrolimus. Twenty-three healthy subjects served as controls. None of the patients or controls suffered from diabetes mellitus or an acute infection at the time of the study. Plasma malondialdehyde (MDA), plasma selenium (Se), erythrocyte glutathione peroxidase (GSH-Px), erythrocyte superoxide dismutase (SOD), erythrocyte Zn (EZn), and erythrocyte Cu (ECu) levels were studied before and in the 1st,3rd, 7th, 14th and 28th days after the transplantation. Results: The GSH-Px, SOD, ECu, EZn and selenium levels were lower and MDA levels were higher in patients than controls before transplantation (p < 0.001 for all). MDA levels decreased and SOD, GSH-Px, ECu, EZn levels increased in parallel to the decrement of serum creatinine levels following the renal transplantation. No difference was found among the patients regarding the treatment regime. Conclusion: The study data suggest that the improvement in oxidative state parameters begins at the first day of renal transplantation and continues at the 28th posttransplant day in living donor transplantations.

show abstract

“…The role of reactive oxygen species in human kidney transplantation seems to correlate with results obtained in animal studies. In human renal transplantation studies, increases in myeloperoxidase and lipid peroxide product levels have been demonstrated in the blood of the transplant recipients following revascularization [13][14][15]. In this study, we have investigated whether TMZ has a protective effect on renal tissue subjected to IR injury.…”

Section: Discussionmentioning

confidence: 99%

Cytoprotective Effect of Trimetazidine on 75 min Warm Renal Ischemia-Reperfusion Injury in Rats

et al. 1998

View full text Add to dashboard Cite

In this experimental study, we evaluated the effect of trimetazidine (TMZ) on renal ischemia-reperfusion (IR) injury in Sprague-Dawley rats. Renal IR was achieved by a 75-min clamping of the left renal pedicle and subsequent 24 h reperfusion, after right nephrectomy was performed. The rats were randomly divided into three groups: group 1 (sham operated: no IR injury), group 2 (ischemic control: saline treatment), and group 3 (3 mg/kg TMZ before ischemia). After 24 h of reperfusion, blood samples and renal tissue samples were taken to measure the levels of creatinine, tissue malondialdehyde (MDA), and glutathione peroxidase (GSH-Px) activity. Histopathological changes were evaluated. In addition, the 7-day survival rates in each group were evaluated. We found significant increases in the levels of creatinine and tissue MDA, severe acute tubular necrosis, and a significant decrease in the activity of the GSH-Px in group 2. There were significant decreases in the levels of creatinine and tissue MDA, mild acute tubular necrosis, and a significant increase in activity of the GSH-Px in group 3 when compared with the control group (p <0.05). Statistically significant differences (p <0.05) in survival were noted between the ischemic control and sham-operated and TMZ groups. We have concluded that TMZ is able to protect the kidney from warm IR injury.

show abstract

Oxygen Free Radicals and Platelet and Granulocyte Aggregability in Renal Transplant Patients

Cited by 48 publications

References 0 publications

The Dynamics of the Oxidant-Antioxidant Balance in the Early Phase of Human Acute Biliary Pancreatitis

The Dynamics of the Oxidant-Antioxidant Balance in the Early Phase of Human Acute Biliary Pancreatitis

Assessment of Oxidative Stress in the Early Posttransplant Period: Comparison of Cyclosporine A and Tacrolimus-Based Regimens

Cytoprotective Effect of Trimetazidine on 75 min Warm Renal Ischemia-Reperfusion Injury in Rats

Contact Info

Product

Resources

About