Oxygen-generating materials and their biomedical applications: a review

Oxygen‐Generating Hydrogels as Oxygenation Therapy for Accelerated Chronic Wound Healing

“…Among them, CaO 2 is the most commonly used solid peroxide, serving as a versatile O 2 source due to its relatively low toxicity and moderate reaction speed. [ 8 ] It is worth mentioning that H 2 O 2 is not an obligatory intermediate in the decomposition of CaO 2 into O 2 . The production of H 2 O 2 and O 2 from CaO 2 is a competitive process, and the release rate of O 2 can be controlled by factors such as temperature and pH.…”

“…Owing to tissue damage, poor blood supply, intensified inflammation reaction, and pathophysiologic conditions in chronic wounds, severe hypoxia occurs when the pO 2 level drops below 8 mmHg. [8] The hypoxic microenvironment in chronic wounds not only alters the inflammatory response and causes persistent inflammation, making the wound more susceptible to bacterial colonization and infections, but also impairs the function of fibroblasts and endothelial cells, hindering angiogenesis, wound closure and tissue remodeling. [9] To ameliorate hypoxia, hyperbaric oxygen (HBO) therapy and topical gaseous oxygen (TGO) devices such as OxyBand (Oxy-Band Technologies), Natrox (Inotec) have been clinically applied for repairing chronic wounds.…”

GSH-Responsive Metal–Organic Framework-Based Nanoplatform for Combined Chemo–Chemodynamic Therapy

“…Several efforts have been directed toward increasing the H 2 O 2 levels in CDT via incorporating H 2 O 2 generators, 29 e.g., glucose oxidase, β-lapachone, Au nanoparticles, and calcium peroxide (CaO 2 ). 17, 29 The ability of CaO 2 to produce O 2 and H 2 O 2 simultaneously via reaction with H 2 O is advantageous in CDT, 17 although CaO 2 must be encapsulated to avoid premature decomposition. It is also well accepted that an overload of Ca 2+ in the cells as a result of CaO 2 decomposition would eventually lead to calcination and malfunction of channels, destroy intracellular proteins, and particularly damage mitochondria, thereby enhancing the tumor suppressing effects.…”

Harnessing the potential of oxygen-generating materials and their utilization in organ-specific delivery of oxygen

“…Many researchers have reviewed several aspects of O 2 generating materials in tissue engineering including, the role of O 2 in TE 32 and various O 2 release mechanisms from OGMs, 24,33 as well as the need for controlled delivery of O 2 27,28 and approaches to minimize the toxicity of OGM, potential of OGM in ex vivo, in situ and bioprinting. 34 However, in the current review we emphasize how oxygen-generating materials are useful in various TE approaches with a focus on the oxygen requirement of that specific tissue and fulfilling such requirement in engineering tissues.…”