Oxygen-generating nanobiomaterials for the treatment of diabetes

Gholipourmalekabadi, Mazaher; Jajarmi, Vahid; Rezvani, Zahra; Ghaffari, Maryam; Verma, K.D.; Shirinzadeh, Haji; Mozafari, Masoud

doi:10.1016/b978-0-323-42865-1.00012-x

Cited by 2 publications

(2 citation statements)

References 128 publications

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“…However, there is a need for more research on this topic ( Eftekhari et al, 2021 ). Apart from their significance in regenerative medicine, antimicrobials, drug delivery, and stem biology, Nanobiomaterials can be used for the treatment of diabetes mellitus 1 by generating supplemental oxygen required by islets until the formation of blood vessels ( Gholipourmalekabadi et al, 2016 ). Electrospinning uses the principles of nanobiotechnology for the preparation of biocompatible scaffolds which mimic collagen nanofibers providing protection and mechanical support at the injury site ( Farshi et al, 2022 ).…”

Section: Effects Of Nanoparticles On B Cellsmentioning

confidence: 99%

Emerging applications of nanotechnology in context to immunology: A comprehensive review

Mobeen

Safdar

Fatima

et al. 2022

Front. Bioeng. Biotechnol.

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Numerous benefits of nanotechnology are available in many scientific domains. In this sense, nanoparticles serve as the fundamental foundation of nanotechnology. Recent developments in nanotechnology have demonstrated that nanoparticles have enormous promise for use in almost every field of life sciences. Nanoscience and nanotechnology use the distinctive characteristics of tiny nanoparticles (NPs) for various purposes in electronics, fabrics, cosmetics, biopharmaceutical industries, and medicines. The exclusive physical, chemical, and biological characteristics of nanoparticles prompt different immune responses in the body. Nanoparticles are believed to have strong potential for the development of advanced adjuvants, cytokines, vaccines, drugs, immunotherapies, and theranostic applications for the treatment of targeted bacterial, fungal, viral, and allergic diseases and removal of the tumor with minimal toxicity as compared to macro and microstructures. This review highlights the medical and non-medical applications with a detailed discussion on enhanced and targeted natural and acquired immunity against pathogens provoked by nanoparticles. The immunological aspects of the nanotechnology field are beyond the scope of this Review. However, we provide updated data that will explore novel theragnostic immunological applications of nanotechnology for better and immediate treatment.

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Section: Effects Of Nanoparticles On B Cellsmentioning

confidence: 99%

Emerging applications of nanotechnology in context to immunology: A comprehensive review

Mobeen

Safdar

Fatima

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

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“…Another example was reported by Wang et al 2010, who developed antimicrobial calcium peroxide (CP)-incorporated polycaprolactone nanofibers. These CP particles can release oxygen and other oxygen species to support tissue engineering and wound healing platforms 63 , 79 , 80 . Specifically, CP dissociates to form calcium hydroxide and hydrogen peroxide (Eq.…”

Section: Introductionmentioning

confidence: 99%

Needle-injectable microcomposite cryogel scaffolds with antimicrobial properties

Joshi‐Navare

Colombani

Rezaeeyazdi

et al. 2020

Sci Rep

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Porous three-dimensional hydrogel scaffolds have an exquisite ability to promote tissue repair. However, because of their high water content and invasive nature during surgical implantation, hydrogels are at an increased risk of bacterial infection. Recently, we have developed elastic biomimetic cryogels, an advanced type of polymeric hydrogel, that are syringe-deliverable through hypodermic needles. These needle-injectable cryogels have unique properties, including large and interconnected pores, mechanical robustness, and shape-memory. Like hydrogels, cryogels are also susceptible to colonization by microbial pathogens. To that end, our minimally invasive cryogels have been engineered to address this challenge. Specifically, we hybridized the cryogels with calcium peroxide microparticles to controllably produce bactericidal hydrogen peroxide. Our novel microcomposite cryogels exhibit antimicrobial properties and inhibit antibiotic-resistant bacteria (MRSA and Pseudomonas aeruginosa), the most common cause of biomaterial implant failure in modern medicine. Moreover, the cryogels showed negligible cytotoxicity toward murine fibroblasts and prevented activation of primary bone marrow-derived dendritic cells ex vivo. Finally, in vivo data suggested tissue integration, biodegradation, and minimal host inflammatory responses when the antimicrobial cryogels, even when purposely contaminated with bacteria, were subcutaneously injected in mice. Collectively, these needle-injectable microcomposite cryogels show great promise for biomedical applications, especially in tissue engineering and regenerative medicine.

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Oxygen-generating nanobiomaterials for the treatment of diabetes

Cited by 2 publications

References 128 publications

Emerging applications of nanotechnology in context to immunology: A comprehensive review

Emerging applications of nanotechnology in context to immunology: A comprehensive review

Needle-injectable microcomposite cryogel scaffolds with antimicrobial properties

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