Oxygen in critically ill patients: It is time to look at the other face of Janus

Effects of intraoperative high versus low inspiratory oxygen fraction (FiO2) on patient's outcome: A systematic review of evidence from the last 20 years

“…Clinical evidences are in line with experimental findings as ROS metabolism seems to be implicated in the deleterious effects of ischemia-reperfusion following resuscitation from cardiac arrest and myocardial infarction [30][31][32]. Moreover, it is now advocated that oxygen therapy should carefully be prescribed in acutely ill patients as morbidity, and maybe mortality, seem linked to the amount of oxygen delivered [33]. Actually, it has been reported that acutely ill patients treated with conservative oxygen therapy may have a better outcome than those treated with a liberal oxygen strategy [34][35][36].…”