Oxygen in the Evolution of Complex Life and the Price We Pay

Thannickal, Victor J.

doi:10.1165/rcmb.2008-0360ps

Cited by 92 publications

(50 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The respiratory and the cardiovascular systems co-evolved to allow transport of atmospheric O 2 to cells=tissues of internal organs in larger organisms that became dependent on aerobic metabolism, but were limited by the diffusibility of O 2 across multiple cell layers (124). The chemical properties of O 2 and ROS appear to have been exploited further in the emergence of biologic complexity; an increasing number of NOX isoforms have emerged with mammalian evolution (11,51,116).…”

Section: Discussionmentioning

confidence: 99%

NOX Enzymes and Pulmonary Disease

Griffith

Pendyala²,

Hecker³

et al. 2009

Antioxidants & Redox Signaling

Self Cite

134

112

View full text Add to dashboard Cite

The primary function of the lung is to facilitate the transfer of molecular oxygen (O 2 ; dioxygen) from the atmosphere to the systemic circulation. In addition to its essential role in aerobic metabolism, O 2 serves as the physiologic terminal acceptor of electron transfer catalyzed by the NADPH oxidase (NOX) family of oxidoreductases. The evolution of the lungs and circulatory systems in vertebrates was accompanied by increasing diversification of NOX family enzymes, suggesting adaptive roles for NOX-derived reactive oxygen species in normal physiology. However, this adaptation may paradoxically carry detrimental consequences in the setting of overwhelming=persistent environmental stressors, both infectious and noninfectious, and during the process of aging. Here, we review current understanding of NOX enzymes in normal lung physiology and their pathophysiologic roles in a number of pulmonary diseases, including lung infections, acute lung injury, pulmonary arterial hypertension, obstructive lung disorders, fibrotic lung disease, and lung cancer. Antioxid. Redox Signal. 11, 2505-2516.

show abstract

Section: Discussionmentioning

confidence: 99%

NOX Enzymes and Pulmonary Disease

Griffith

Pendyala²,

Hecker³

et al. 2009

Antioxidants & Redox Signaling

Self Cite

134

112

View full text Add to dashboard Cite

show abstract

“…Gilbert (1960Gilbert ( , 1996 and several subsequent authors (Catling et al 2005;Koch and Britton 2008;Thannickal 2009) have pointed out that oxygen is the optimal electron acceptor for respiration. Oxygen yields more energy per electron transfer than any other element available in appreciable concentrations, is sufficiently stable to build up to appreciable concentrations in Earth's atmosphere (unlike the more reactive halogens such as fluorine, chlorine, and bromine), and is abundant in a biologically available form-liquid water.…”

Section: History Of Atmospheric Oxygenmentioning

confidence: 99%

The evolutionary consequences of oxygenic photosynthesis: a body size perspective

et al. 2010

View full text Add to dashboard Cite

The high concentration of molecular oxygen in Earth's atmosphere is arguably the most conspicuous and geologically important signature of life. Earth's early atmosphere lacked oxygen; accumulation began after the evolution of oxygenic photosynthesis in cyanobacteria around 3.0-2.5 billion years ago (Gya). Concentrations of oxygen have since varied, first reaching near-modern values ~600 million years ago (Mya). These fluctuations have been hypothesized to constrain many biological patterns, among them the evolution of body size. Here, we review the state of knowledge relating oxygen availability to body size. Laboratory studies increasingly illuminate the mechanisms by which organisms can adapt physiologically to the variation in oxygen availability, but the extent to which these findings can be extrapolated to evolutionary timescales remains poorly understood. Experiments confirm that animal size is limited by experimental hypoxia, but show that plant vegetative growth is enhanced due to

show abstract

“…The concept of antagonistic pleiotropy was proposed by Williams in 1957 to explain senescence and aging (40); however, this concept may even more aptly apply to a number of complex, age-related diseases (41,42). If a particular gene mediates beneficial effects in early life but exerts detrimental effects after reproductive age, there will be evolutionary pressure to conserve that gene despite its potential disease-causing effects with aging.…”

Section: Role Of Infectious or Noninfectious Antigensmentioning

confidence: 99%