Oxygen physiology: sensors and ion channels

Mori, Yasuo; Takahashi, Nobuaki; Ogawa, Norio; Gudermann, Thomas

doi:10.1007/s00424-015-1762-9

Cited by 5 publications

(6 citation statements)

References 12 publications

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“…PAT1 (SLC36A1) was found to mediate the transportation of amino acids such as proline ( 95 ) and act as an amino acid transceptor for the activation of TOR signaling in several cell lines ( 96 ). In addition, the major neutral amino acid transporter b 0 at1 ( slc6a19 ) ( 97 ) and cationic amino acid transporter b 0,+ at ( slc7a9 ) ( 98 ) were identified in turbot muscle in our previous study ( 99 ) and were found to be upregulated in the present study (Figure 5 D). These data suggested that the intracellular amino acid availabilities, activation of TOR signaling, and downstream anabolic processes were tightly coordinated and regulated.…”

Section: Discussionsupporting

confidence: 70%

The Mitotic and Metabolic Effects of Phosphatidic Acid in the Primary Muscle Cells of Turbot (Scophthalmus maximus)

Wang

Zhou

et al. 2018

Front. Endocrinol.

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Searching for nutraceuticals and understanding the underlying mechanism that promote fish growth is at high demand for aquaculture industry. In this study, the modulatory effects of soy phosphatidic acids (PA) on cell proliferation, nutrient sensing, and metabolic pathways were systematically examined in primary muscle cells of turbot (Scophthalmus maximus). PA was found to stimulate cell proliferation and promote G1/S phase transition through activation of target of rapamycin signaling pathway. The expression of myogenic regulatory factors, including myoD and follistatin, was upregulated, while that of myogenin and myostatin was downregulated by PA. Furthermore, PA increased intracellular free amino acid levels and enhanced protein synthesis, lipogenesis, and glycolysis, while suppressed amino acid degradation and lipolysis. PA also was found to increased cellular energy production through stimulated tricarboxylic acid cycle and oxidative phosphorylation. Our results identified PA as a potential nutraceutical that stimulates muscle cell proliferation and anabolism in fish.

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Section: Discussionsupporting

confidence: 70%

The Mitotic and Metabolic Effects of Phosphatidic Acid in the Primary Muscle Cells of Turbot (Scophthalmus maximus)

Wang

Zhou

et al. 2018

Front. Endocrinol.

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“…Voltage-induced conformational changes in GPCRs have recently also been confirmed directly by FRET-based reporters [18 •• ]. Through both GIRK and FRET measurements, it has been shown that voltage can have opposite effects on the transmitted signal induced by agonist action on the receptors [11, 18••, 22•]. For example, the GIRK current elicited by acetylcholine binding to M 2 receptors in rabbit or feline atrial myocytes is reduced by depolarisation, while that caused by the agonist pilocarpine is strongly enhanced [11, 22•].…”

Section: Experimental Evidence For Voltage-induced Effects In Gpcrsmentioning

confidence: 99%

“…These channel proteins contain specialised voltage-sensing domains, which are capable of inducing large-scale conformational transitions that gate the channels open or closed, even under small changes of V m [17]. By contrast, voltage-related effects on other membrane proteins such as GPCRs seem less intuitive, although a number of studies have reported compelling evidence for a broad range of V m -induced phenomena in GPCRs [11, 18••, 19, 20, 21, 22•] (for review see Ref [23]). Many important class A GPCR drug targets are expressed in excitable tissue, for instance the aminergic, opioid, adrenergic and purinergic receptors.…”

Section: Introductionmentioning

confidence: 99%

Membrane potentials regulating GPCRs: insights from experiments and molecular dynamics simulations

Vickery

Machtens

Zachariae

2016

Current Opinion in Pharmacology

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“…Some recent examples underline the unique ability of TRPA1 to sense the redox state of the milieu and, via this mechanism, to signal pain evoked by anticancer treatments. Chemotherapeutic drugs, including bortezomib, oxaliplatin and paclitaxel, elicit cold and mechanical allodynia in mice via oxidative stress‐dependent TRPA1 activation .…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12][13][14] In addition to exogenous agonists, such as allyl isothiocyanate (AITC, in mustard oil and wasabi), cinnamaldehyde (in cinnamon) and allicin (in garlic), an unprecedented series of endogenous pro-inflammatory substances produced at sites of inflammation or tissue injury, including reactive oxygen, nitrogen and carbonyl species (ROS, RNS and RCS, respectively), directly gate TRPA1. [10][11][12][15][16][17] Some recent examples underline the unique ability of TRPA1 to sense the redox state of the milieu 18 and, via this mechanism, to signal pain evoked by anticancer treatments. Chemotherapeutic drugs, including bortezomib, oxaliplatin and paclitaxel, elicit cold and mechanical allodynia in mice via oxidative stress-dependent TRPA1 activation.…”

Section: Introductionmentioning

confidence: 99%

Transient receptor potential ankyrin 1 (TRPA1) plays a critical role in a mouse model of cancer pain

Antoniazzi

Nassini

Rigo

et al. 2018

Intl Journal of Cancer

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There is a major, unmet need for the treatment of cancer pain, and new targets and medicines are required. The transient receptor potential ankyrin 1 (TRPA1), a cation channel expressed by nociceptors, is activated by oxidizing substances to mediate pain‐like responses in models of inflammatory and neuropathic pain. As cancer is known to increase oxidative stress, the role of TRPA1 was evaluated in a mouse model of cancer pain. Fourteen days after injection of B16‐F10 murine melanoma cells into the plantar region of the right hind paw, C57BL/6 mice exhibited mechanical and thermal allodynia and thigmotaxis behavior. While heat allodynia was partially reduced in TRP vanilloid 1 (TRPV1)‐deficient mice, thigmotaxis behavior and mechanical and cold allodynia were absent in TRPA1‐deficient mice. Deletion of TRPA1 or TRPV1 did not affect cancer growth. Intrathecal TRPA1 antisense oligonucleotides and two different TRPA1 antagonists (HC‐030031 or A967079) transiently attenuated thigmotaxis behavior and mechanical and cold allodynia. A TRPV1 antagonist (capsazepine) attenuated solely heat allodynia. NADPH oxidase activity and hydrogen peroxide levels were increased in hind paw skin 14 days after c ancer cell inoculation . The antioxidant, α‐lipoic acid, attenuated mechanical and cold allodynia and thigmotaxis behavior, but not heat allodynia. Whereas TRPV1, via an oxidative stress‐independent pathway, contributes partially to heat hypersensitivity, oxidative stress‐dependent activation of TRPA1 plays a key role in mediating thigmotaxis behavior and mechanical and cold allodynia in a cancer pain model. TRPA1 antagonists might be beneficial in the treatment of cancer pain.

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Oxygen physiology: sensors and ion channels

Cited by 5 publications

References 12 publications

The Mitotic and Metabolic Effects of Phosphatidic Acid in the Primary Muscle Cells of Turbot (Scophthalmus maximus)

The Mitotic and Metabolic Effects of Phosphatidic Acid in the Primary Muscle Cells of Turbot (Scophthalmus maximus)

Membrane potentials regulating GPCRs: insights from experiments and molecular dynamics simulations

Transient receptor potential ankyrin 1 (TRPA1) plays a critical role in a mouse model of cancer pain

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