Oxygen Poisoning in Cold Blooded Animals

Faulkner, James M.; Binger, Carl A. L.

doi:10.1084/jem.45.5.865

Cited by 24 publications

(5 citation statements)

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“…11 Experiments over the first part of the last century revealed that younger animals were relatively “resistant” to the toxic effects of oxygen when compared to their adult counterparts. This was true for turtles, 12 rats, 13 fruit flies, 14 and cats. 15 In 1957, it was noted that neonatal rats were resistant to oxygen toxicity.…”

Section: The Response To Oxidative Stress Varies Across Development Amentioning

confidence: 83%

Oxidative stress diseases unique to the perinatal period: A window into the developing innate immune response

Dietz

Wright

2017

American J Rep Immunol

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The innate immune system has evolved to play an integral role in the normally developing lung and brain. However, in response to oxidative stress, innate immunity, mediated by specific cellular and molecular programs and signaling, contributes to pathology in these same organ systems. Despite opposing drivers of oxidative stress, namely hyperoxia in neonatal lung injury and hypoxia/ischemia in neonatal brain injury, similar pathways-including toll-like receptors, NFκB and MAPK cascades-have been implicated in tissue damage. In this review, we consider recent insights into the innate immune response to oxidative stress in both neonatal and adult models to better understand hyperoxic lung injury and hypoxic-ischemic brain injury across development and aging. These insights support the development of targeted immunotherapeutic strategies to address the challenge of harnessing the innate immune system in oxidative stress diseases of the neonate.

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Section: The Response To Oxidative Stress Varies Across Development Amentioning

confidence: 83%

Oxidative stress diseases unique to the perinatal period: A window into the developing innate immune response

Dietz

Wright

2017

American J Rep Immunol

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“…The skin of X. laevis normally absorbs oxygen from water with a DO concentration of 6–7 mg/L; thus, some parts of the body surface exposed to air in reoxygenation may be exposed to hyperoxia. Although hyperoxia exposure is generally associated with tissue injury, frog was reported to show no noticeable changes in the lungs and other tissues after long‐term chronic exposure to hyperoxia (i.e., above 90% O 2 at room temperature) (Faulkner & Binger, 1927). Therefore, the tissue injury observed in this study may be attributed to oxidative stress due to intermittent hypoxic exposure rather than due to hyperoxic exposure.…”

Section: Resultsmentioning

confidence: 99%

Detection of hypoxia in the pulmonary tissues of Xenopus laevis over repeated dives

2023

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The oxygen environment in African clawed frogs (Xenopus laevis) continuously changes during their development, which involves a rapid increase in the body size, metamorphosis, and transition to adulthood. Nevertheless, there are limited reports on experimental models that are available for studying fluctuations in the oxygen environment in X. laevis. Thus, this study aimed to develop an experimental model on intermittent hypoxia in X. laevis and evaluate hypoxia and oxidative stress in the same. X. laevis were submerged in water with a dissolved oxygen concentration of 2 mg/L for 30 min; they were then removed from the water and allowed to freely absorb oxygen for 5 min. Immunostaining of pimonidazole‐containing frozen tissue sections of the lung and liver using anti‐pimonidazole antibodies as the hypoxia probes revealed that more than 95% of the submerged X. laevis cells were pimonidazole positive, providing direct evidence of tissue hypoxia. When the amount of oxidative stress in the lungs and liver was evaluated in terms of the amount of lipid peroxides, the diving group showed a 2.08‐fold and 3.20‐fold increase over the normal group, respectively. Following hypoxia exposure, the dry‐to‐wet weight ratios of the lung tissues was 1.27 times higher (p < .05), while the liver tissues was 1.06 times higher (although not significant). Thus, the degree of damage depended on the tissues affected. In the future, we believe that this model will be a promising option for analyzing the physiological responses of X. laevis to hypoxia and oxidative stress.

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“…In spite of the fact that fatal cases apparently less often reach a saturation of 90 per cent in the chamber than those which survive, difficult and expensive to maintain when there is frequent ingress and egress from the chamber as there must be in caring for a sick patient, partly because it does not seem wise to approach too closely the toxic concentration of oxygen in the presence of an already damaged lung and elevated temperature (14). The division of these cases into two groups, one which recovered and one which succumbed, is perhaps not a logical one, but it is convenient.…”

Section: Methodsmentioning

confidence: 99%