Oxygen producing biomaterials for tissue regeneration

Harrison, Benjamin S.; Eberli, Daniel; Lee, Sang Jin; Atala, Anthony; Yoo, James J.

doi:10.1016/j.biomaterials.2007.07.003

Cited by 218 publications

(219 citation statements)

References 15 publications

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“…Limiting or eliminating the hypoxic period between implantation and the development of a fully functional, intradevice, vascular network would dramatically reduce hypoxia-induced cell death and permit for more clinically translatable devices. Such methods include prevascularization of the transplant site (12), hastening vascularization through the delivery of growth factors (13,14), incorporation of oxygen carriers within biomaterials (15), or the in situ generation of supplemental oxygen (16)(17)(18)(19). In situ oxygen generation is a highly desirable approach, in that it does not require multiple surgeries and provides supplemental oxygen immediately upon implantation.…”

mentioning

confidence: 99%

“…Encapsulation of solid peroxide within a polymer could serve to temper its hydrolytic reactivity. A solid peroxide platform using films of poly (lactic-co-glycolic acid) (PLGA) has been published, whereby the oxygen-generating potential of these materials was shown through enhanced fibroblast proliferation and reduced necrosis in a skin flap mouse model (16,17). The benefit of the films, however, was short lived, and the reaction kinetics were less controlled owing to the hydrolytic degradation of the PLGA.…”

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confidence: 99%

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Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated, oxygen-generating biomaterials

Pedraza

Coronel

Fraker

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

358

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A major hindrance in engineering tissues containing highly metabolically active cells is the insufficient oxygenation of these implants, which results in dying or dysfunctional cells in portions of the graft. The development of methods to increase oxygen availability within tissue-engineered implants, particularly during the early engraftment period, would serve to allay hypoxiainduced cell death. Herein, we designed and developed a hydrolytically activated oxygen-generating biomaterial in the form of polydimethylsiloxane (PDMS)-encapsulated solid calcium peroxide, PDMS-CaO 2 . Encapsulation of solid peroxide within hydrophobic PDMS resulted in sustained oxygen generation, whereby a single disk generated oxygen for more than 6 wk at an average rate of 0.026 mM per day. The ability of this oxygen-generating material to support cell survival was evaluated using a β cell line and pancreatic rat islets. The presence of a single PDMS-CaO 2 disk eliminated hypoxia-induced cell dysfunction and death for both cell types, resulting in metabolic function and glucose-dependent insulin secretion comparable to that in normoxic controls. A single PDMS-CaO 2 disk also sustained enhanced β cell proliferation for more than 3 wk under hypoxic culture conditions. Incorporation of these materials within 3D constructs illustrated the benefits of these materials to prevent the development of detrimental oxygen gradients within large implants. Mathematical simulations permitted accurate prediction of oxygen gradients within 3D constructs and highlighted conditions under which supplementation of oxygen tension would serve to benefit cellular viability. Given the generality of this platform, the translation of these materials to other cell-based implants, as well as ischemic tissues in general, is envisioned.tissue engineering | encapsulation | bioartificial pancreas | diabetes

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mentioning

confidence: 99%

mentioning

confidence: 99%

Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated, oxygen-generating biomaterials

Pedraza

Coronel

Fraker

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

358

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“…56,57 For example, fluorinated compounds 58 or peroxides have been incorporated into scaffolds to enable the controlled release of oxygen. 51,59 Such 3D biomimetic materials can be fabricated in the form of thin polymer films, 60 electrospun fibers, 61 porous scaffolds 62 and hydrogels. 63,64 The use of oxygen-releasing materials is particularly useful for providing sufficient amount of oxygen, especially during the early stages of in vitro cultures and in vivo implants.…”

Section: Conductive Hydrogelsmentioning

confidence: 99%

Hydrogels for cardiac tissue engineering

et al. 2014

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“…They can serve as a scaffold designed to replace, repair, and sustain organ structures. In the past decade, numerous scaffolds have been developed for a variety of tissue-engineering applications (7)(8)(9)(10)(11). However, limitations of the scaffolds involve mechanical material failure, material-associated infection, and immunogenic reaction to implanted materials.…”

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confidence: 99%

Biomaterial Scaffolds in Pediatric Tissue Engineering

Patel

Fisher

2008

Pediatr Res

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This article reviews recent developments and major issues in the use and design of biomaterials for use as scaffolds in pediatric tissue engineering. A brief history of tissue engineering and the limitations of current tissue-engineering research with respect to pediatric patients have been introduced. An overview of the characteristics of an ideal tissue-engineering scaffold for pediatric applications has been presented, including a description of the different types of scaffolds. Applications of scaffolds materials have been highlighted in the fields of drug delivery, bone, cardiovascular, and skin tissue engineering with respect to the pediatric population. This review highlights biomaterials as scaffolds as an alternative treatment method for pediatric surgeries due to the ability to create a functional cell-scaffold environment.

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Oxygen producing biomaterials for tissue regeneration

Cited by 218 publications

References 15 publications

Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated, oxygen-generating biomaterials

Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated, oxygen-generating biomaterials

Hydrogels for cardiac tissue engineering

Biomaterial Scaffolds in Pediatric Tissue Engineering

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