Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation

Abstract

Oxygen-glucose deprivation detrimentally affected mesenchymal stem cells, which could be reversed by the addition of oxygen producing spheres.

Self‐Oxygenation of Tissues Orchestrates Full‐Thickness Vascularization of Living Implants

“…Several oxygen releasing and generating strategies have already been developed, for example, hemoglobin and myoglobin substitutes, polymer-based oxygen carriers, perfluorocarbons, and solid peroxides. [15][16][17][18][19] These compounds and materials have the ability to bind, dissolve, or generate physiologically relevant quantities of oxygen, but typically release their payloads within minutes to hours. In contrast, alleviating the oxygen deprivation during the prevascular phase of large implants demands release periods of multiple days to weeks.…”

Optimizing an Injectable Composite Oxygen-Generating System for Relieving Tissue Hypoxia

“…Upon exposure to water, peroxide materials break down to yield hydrogen peroxide (H 2 O 2 ), which can be further converted into molecular oxygen and water by catalysts (Farris et al, 2016;Gholipourmalekabadi et al, 2016). As the rate of oxygen generation depends on several environmental factors (Gholipourmalekabadi et al, 2016), such as humidity, pH, temperature, and the presence of catalysts, peroxide materials have been incorporated in a variety of biomaterials in the formats of films (Harrison et al, 2007), particles (Newland et al, 2018), and fibers (Wang J. et al, 2011) to achieve the sustained release of oxygen. This technique has been explored to provide oxygen for application in the field of regenerative medicine, including ischemic diseases (Harrison et al, 2007), cell transplantation (Pedraza et al, 2012;Coronel et al, 2017;Fan et al, 2018), wound healing (Chandra et al, 2015), and tissue engineering (Oh et al, 2009).…”

Local delivery to malignant brain tumors: potential biomaterial-based therapeutic/adjuvant strategies

“…122 Catalase is a hemoprotein enzyme that is found in most cells and decomposes H 2 O 2 to oxygen and water. 111 It has therefore often been used with oxygen-generating biomaterials through conjugation with the carrier, 123 embedding within the carrier, 60,116 or being added to the surrounding medium, 125 though in principle, other catalytic agents such as potassium iodide, 126 platinum, 116,127,128 palladium, 128 rhodium, 129 hemin 130 and manganese dioxide 131 could also be utilized.…”