Oxygen pulse as a protective factor of insulin resistance in sedentary women with overweight or obesity

Abstract

Background: Obesity is associated with insulin resistance (IR). Through exercise insulin resistant obese patients can effectively improve their cardiorespiratory fitness (CRF). The effect of exercise on patients CRF can be determined by oxygen pulse (PO2) analysis. Despite its usefulness, there is limited literature on PO2 analysis in patients with obesity and insulin resistance. Objective: The goal of the present study is to evaluate the relation between PO2 and IR in sedentary obese women. Methods: 55 women were submitted to a maximal exercise test for evaluation of maximal oxygen consumption and PO2. The subjects with a Homeostatic model assessment of IR index greater or equal to 2.5 were considered as insulin-resistant. Participants were divided into 2 groups, IR group (n=35) and Non-IR group (n=20). Results: IR group had lower values of PO2 relative to body weight (11.0±1.7 versus 12.6±1.4 ml∙kg∙beats-1, p=0.001) and relative to lean mass (21.7±2.9 versus 23.2±2.8 ml∙kg∙beats-1, p=0.038) than Non- IR group. No statistical differences were found in maximal oxygen consumption between groups (Non IR=1.53±0.27 L∙min-1, IR=1.51±0.28 L∙min-1; p=0.386). PO2 relative to body weight and HOMA-IR was inversely correlated (p<0.001; r=-0.465). Logistic regression analysis showed an association between PO2 relative to weight (p=0.001, OR=0.47) and fat free mass (p=0.01, OR=0.73), both models adjusted by age. Conclusions: This study demonstrates a relation between HOMA-IR and PO2. Our results suggest that PO2 could be a protective factor against insulin resistance.

Effects ofPoria cocosextract and protein powder mixture on glucolipid metabolism and rhythm changes in obese mice

“…Studies have shown that with an increase in TNF‐α and IL‐1 β levels, the TC, LEP, and ADP levels increase, suggesting that the levels of inflammatory factors may affect glucose and lipid metabolisms (Xue et al, 2005 ). TNF‐α is a pro‐inflammatory cytokine that reduces the response of adipocytes, hepatocytes, and muscle cell responses to insulin (Ramírez Alvarado & Sánchez Roitz, 2012 ). Additionally, TNF‐α is involved in insulin resistance‐induced apoptosis and atrophy of brown adipocytes, promoting the development of hyperinsulinemia combined with obesity and driving the progression of insulin resistance (S. Wang et al, 2021 ).…”