Oxygen Radicals and Neuropsychiatric Illness

A comparison of the generation of free radicals in saliva of active and passive smokers

“…Since free radicals are potentially toxic, organisms have developed defense systems to eliminate them. These are called antioxidants (5). Cells inactivate enzymes, the peroxides of which are called the antioxidant defense system, and synthesize proteins that attract transition metals and scavenge free radicals, thus preventing the generation of free radicals and thereby limiting the damage caused by free radicals (6).…”

Oxidative Stress-Induced Response of Some Endogenous Antioxidants in Schizophrenia

“…The brain tissue contains large amounts of unsaturated fatty acid, catecholamines, increased oxygen consumption, presence of transition metals making the neuronal membrane uniquely vulnerable to free radical mediated damage [5], that may be important in diseases like Alzheimers, Schizophrenia, etc. [6].…”

Study of oxidative stress in obsessive compulsive disorder in response to treatment with Fluoxetine

“…It has been reported that basal ganglia are particularly vulnerable to damage by free radicals due to the large concentration of catecholamine in this region (9). The comorbidity of OCD and other neurological disorders like Sydenham's chorea and Parkinson's disease raises the chance of basal ganglia involvement in this disorder (10). Today, for the treatment of OCD, Fluoxetine is widely used due to its low side effects, good therapeutic response and good compliance (11).…”