Oxygen-Releasing Biomaterials: Current Challenges and Future Applications

Willemen, Niels; Hassan, Shabir; Gurian, Melvin; Li, Jinghang; Allijn, Iris E.; Shin, Su Ryon; Leijten, Jeroen

doi:10.1016/j.tibtech.2021.01.007

Cited by 65 publications

(62 citation statements)

References 111 publications

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“…Several oxygen releasing and generating strategies have already been developed, for example, hemoglobin and myoglobin substitutes, polymer-based oxygen carriers, perfluorocarbons, and solid peroxides. [15][16][17][18][19] These compounds and materials have the ability to bind, dissolve, or generate physiologically relevant quantities of oxygen, but typically release their payloads within minutes to hours. In contrast, alleviating the oxygen deprivation during the prevascular phase of large implants demands release periods of multiple days to weeks.…”

Section: Introductionmentioning

confidence: 99%

Self‐Oxygenation of Tissues Orchestrates Full‐Thickness Vascularization of Living Implants

Farzin

Hassan

Teixeira

et al. 2021

Adv Funct Materials

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Bioengineering of tissues and organs has the potential to generate functional replacement organs. However, achieving the full-thickness vascularization that is required for long-term survival of living implants has remained a grand challenge, especially for clinically sized implants. During the pre-vascular phase, implanted engineered tissues are forced to metabolically rely on the diffusion of nutrients from adjacent host-tissue, which for larger living implants results in anoxia, cell death, and ultimately implant failure. Here it is reported that this challenge can be addressed by engineering self-oxygenating tissues, which is achieved via the incorporation of hydrophobic oxygen-generating micromaterials into engineered tissues. Self-oxygenation of tissues transforms anoxic stresses into hypoxic stimulation in a homogenous and tissue sizeindependent manner. The in situ elevation of oxygen tension enables the sustained production of high quantities of angiogenic factors by implanted cells, which are offered a metabolically protected pro-angiogenic microenvironment. Numerical simulations predict that self-oxygenation of living tissues will effectively orchestrate rapid full-thickness vascularization of implanted tissues, which is empirically confirmed via in vivo experimentation. Self-oxygenation of tissues thus represents a novel, effective, and widely applicable strategy to enable the vascularization living implants, which is expected to advance organ transplantation and regenerative medicine applications.

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Section: Introductionmentioning

confidence: 99%

Self‐Oxygenation of Tissues Orchestrates Full‐Thickness Vascularization of Living Implants

Farzin

Hassan

Teixeira

et al. 2021

Adv Funct Materials

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“…In a recent report, dextran methacrylate (DexMA) and vinyl sulfone (DexVS) functionalized with an array of adhesive peptides and crosslinked with MMP-sensitive dicysteine peptides has a robust effect in angiogenic sprouting, leading to lumen formation [ 116 ]. Aside from these, several biomaterials show capability for controlled release of various substances, including growth factors and morphogens [ 129 ], oxygen [ 130 ], and drugs [ 131 ] among others. In summary, there is abundant research showing that functionalized synthetic biomaterials can mimic some features of the ECM, including degradation, cell adhesion, and controlled release, which has led to their prevalent use in tissue engineering.…”

Section: The Extracellular Matrixmentioning

confidence: 99%

The ECM: To Scaffold, or Not to Scaffold, That Is the Question

Valdoz

Johnson

Jacobs

et al. 2021

IJMS

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The extracellular matrix (ECM) has pleiotropic effects, ranging from cell adhesion to cell survival. In tissue engineering, the use of ECM and ECM-like scaffolds has separated the field into two distinct areas—scaffold-based and scaffold-free. Scaffold-free techniques are used in creating reproducible cell aggregates which have massive potential for high-throughput, reproducible drug screening and disease modeling. Though, the lack of ECM prevents certain cells from surviving and proliferating. Thus, tissue engineers use scaffolds to mimic the native ECM and produce organotypic models which show more reliability in disease modeling. However, scaffold-based techniques come at a trade-off of reproducibility and throughput. To bridge the tissue engineering dichotomy, we posit that finding novel ways to incorporate the ECM in scaffold-free cultures can synergize these two disparate techniques.

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“…Oxygen-generating biomaterials have been reported to maintain the survival of engrafted engineered tissues 113 as well as treatment of ischemic diseases, 114 chronic wound healing 115 and supporting high metabolic activity tissues such as pancreatic cells 116 and muscle cells. 117 Although oxygengenerating biomaterials have mostly been fabricated to maintain the survival of cells, they could provide an adjuvant effect to enhance the tumor killing capacity of radiotherapy by overcoming the tumor hypoxia.…”

Section: Localized Oxygen-generating Biomaterialsmentioning

confidence: 99%

“…The drawbacks of using solid peroxides as a source of oxygen include the potential for toxicity to surrounding tissue induced either by free radical toxicity of the peroxides, or by solid mineral depositions (mineral hydroxides such as Ca (OH) 2 ) which remain post-oxygen generation. 113 Peroxide toxicity might be overcome by using different delivery systems (carriers) or additives such as catalysts or antioxidants.…”

Section: Oxygen Source Materialsmentioning

confidence: 99%