Oxygen Relieves Breathlessness in "Pink Puffers"

Woodcock, Ashley; Gross, Elizabeth R.; Geddes, Duncan M.

doi:10.1016/s0140-6736(81)91612-3

Cited by 198 publications

(107 citation statements)

References 6 publications

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“…Oksijen inhalasyonu ile KOAH'ta, evreden bağımsız olarak istirahatte PAB değişmezken, egzersiz sırasında özellikle orta ve ileri evre olanlarda PAB artışında önemli derecede azalma bulunmuş-tur (40). Amfizemi olan olgularla yapılan bir çalışma-da, oksijen inhalasyonu ile 6DYT'de %12, dispne algısında %16 düzelme olduğu görülmüştür (41). KOAH tanılı olgularla yapılan başka çalışmalarda ise, istirahatte hafif hipoksemisi olanlarda egzersiz sıra-sında oksijen desteği ile egzersiz toleransında ve dispne algısında akut düzelme izlenmiştir (40)(41)(42)(43)(44).…”

Section: Materyal Ve Metodunclassified

“…Amfizemi olan olgularla yapılan bir çalışma-da, oksijen inhalasyonu ile 6DYT'de %12, dispne algısında %16 düzelme olduğu görülmüştür (41). KOAH tanılı olgularla yapılan başka çalışmalarda ise, istirahatte hafif hipoksemisi olanlarda egzersiz sıra-sında oksijen desteği ile egzersiz toleransında ve dispne algısında akut düzelme izlenmiştir (40)(41)(42)(43)(44). Egzersizle desaturasyonundan bağımsız olarak, ortaileri evre KOAH'lılarda, diğer evrelere göre oksijen desteği ile egzersiz kapasitesindeki artış daha belirgin olarak bulunmuştur (40).…”

Section: Materyal Ve Metodunclassified

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Pulmoner hipertansiyonlu KOAH’lı olgularda pulmoner rehabilitasyon etkinliği

Candemir¹,

Ergün²,

Kaymaz³

et al. 2015

Tuberk Toraks

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Section: Materyal Ve Metodunclassified

Pulmoner hipertansiyonlu KOAH’lı olgularda pulmoner rehabilitasyon etkinliği

Candemir¹,

Ergün²,

Kaymaz³

et al. 2015

Tuberk Toraks

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show abstract

“…[76][77][78] More recent studies in patients with exerciseinduced desaturation report improved ventilatory function, breathlessness, and exercise endurance with the acute administration of oxygen. 69,70,[79][80][81][82][83][84][85][86][87] These studies, however, were short-term and applied oxygen as an acute intervention. No long-term follow-up studies exist.…”

Section: Oxygen Benefits During Exercisementioning

confidence: 99%

The Story of Oxygen

Heffner

2012

Respir Care

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The history of oxygen from discovery to clinical application for patients with chronic lung disease represents a long and storied journey. Within a relatively short period, early investigators not only discovered oxygen but also recognized its importance to life and its role in respiration. The application of oxygen to chronic lung disease, however, took several centuries. In the modern era, physiologists pursued the chemical nature of oxygen and its physiologic interaction with cellular metabolism and gas transport. It took brazen clinicians, however, to pursue oxygen as a therapeutic resource for patients with chronic lung disease because of the concern in the 20th century of the risks of oxygen toxicity. Application of ambulatory oxygen devices allowed landmark investigations of the long-term effects of continuous oxygen that established its safety and efficacy. Although now well established for hypoxic patients, many questions remain regarding the benefits of oxygen for varying severity and types of chronic lung disease.

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“…Although early studies suggested that short burst oxygen reduced dyspnea and increased 6-min walk distance, subsequent studies have not demonstrated a reduction in breathlessness or improved walk test performance. 61,[66][67][68][69][70][71] A randomized single-blind crossover study showed that breathing oxygen at 40% concentration, but not air, for 15 min after exercise in 18 moderately severe COPD patients decreased the time for recovery of dynamic hyperinflation by an average of 6.61 min. 61 Neither the maximal level of dyspnea nor duration of breathlessness was improved by short burst oxygen therapy.…”

Section: Exercisementioning

confidence: 99%

Ambulatory Home Oxygen: What Is the Evidence for Benefit, and Who Does It Help?

Criner

2012

Respir Care

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The beneficial effects of ambulatory home oxygen have been demonstrated since the 1950s, when Cotes and Gibson gave oxygen to ambulatory COPD patients from small portable high pressures cylinders in the United Kingdom. Over the ensuing 7 decades, oxygen has been prescribed to millions of COPD patients in the home setting. Additionally, it is common clinical practice to prescribe supplemental oxygen when chronic hypoxemic respiratory failure not due to COPD (eg, interstitial lung disease, pulmonary hypertension, kyphoscoliosis, and cystic fibrosis) is present or in patients with hypoxemia at hospital discharge following flares of their underlying chronic respiratory disorder, without any substantial evidence. Despite the importance of long-term oxygen therapy in clinical home management, there are many gaps in our current knowledge regarding its mechanisms of action, indications for prescription, and its effects on important patient outcomes. Research conducted in the 1970s and 1980s still provides the basis for clinical decision making and insurance coverage policies regarding long-term oxygen administration. Remarkably, little current research is being conducted to extend our knowledge regarding the indications, mechanisms, and benefits of long-term oxygen therapy. This review will focus on our current knowledge of the end points for supplemental oxygen at home, such as mortality, effects on functional performance, sensation of dyspnea, cognitive function, and quality of life, and highlight areas where future research is needed.

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Oxygen Relieves Breathlessness in "Pink Puffers"

Cited by 198 publications

References 6 publications

Pulmoner hipertansiyonlu KOAH’lı olgularda pulmoner rehabilitasyon etkinliği

Pulmoner hipertansiyonlu KOAH’lı olgularda pulmoner rehabilitasyon etkinliği

The Story of Oxygen

Ambulatory Home Oxygen: What Is the Evidence for Benefit, and Who Does It Help?

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