Oxygen-replenishing manganese oxide catalytic nanoparticles on removable pipette surfaces for hypoxic tumour photodynamic therapy

Tran, Nam; Song, Min Seok; Kim, Gun; Nguyen, Nguyen Binh; Ly, Nguyễn Hoàng; Lee, So Yeong; Joo, Sang‐Woo

doi:10.1016/j.apsusc.2022.154516

Cited by 1 publication

(1 citation statement)

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“…Manganese dioxide (MnO 2 ) NPs have been widely used in research attempts to overcome hypoxia as well as its high catalytic activity that converts H 2 O 2 into O 2 and water (He et al, 2021; Idziak et al, 2020; Tran et al, 2022). The potential of MnO 2 NPs to overcome hypoxia was first noticed by Prasad and colleagues that they investigated albumin and MnO 2 NPs complex (A‐MnO 2 NPs) on EMT6 breast tumors and found that this complex can reduce hypoxia by ~45%, and the tumor pH increased from 6.7 to 7.2 (Prasad et al, 2014).…”

Section: Nanotechnology‐mediated Pdtmentioning

confidence: 99%

Nanotechnology‐mediated photodynamic therapy: Focus on overcoming tumor hypoxia

Moloudi,

Abrahamse,

George

2023

WIREs Nanomed Nanobiotechnol

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The oxygen level in the tumor is a critical marker that determines response to different treatments. Cancerous cells can adapt to hypoxia and low pH conditions within the tumor microenvironment (TME) to regulate tumor metabolism, proliferation, and promote tumor metastasis as well as angiogenesis, consequently leading to treatment failure and recurrence. In recent years, widespread attempts have been made to overcome tumor hypoxia through different methods, such as hyperbaric oxygen therapy (HBOT), hyperthermia, O2 carriers, artificial hemoglobin, oxygen generator hydrogels, and peroxide materials. While oxygen is found to be an essential agent to improve the treatment response of photodynamic therapy (PDT) and other cancer treatment modalities, the development of hypoxia within the tumor is highly associated with PDT failure. Recently, the use of nanoparticles has been a hot topic for researchers and exploited to overcome hypoxia through Oxygen‐generating hydrogels, O2 nanocarriers, and O2‐generating nanoparticles. This review aimed to discuss the role of nanotechnology in tumor oxygenation and highlight the challenges, prospective, and recent advances in this area to improve PDT outcomes.This article is categorized under: Nanotechnology Approaches to Biology > Cells at the Nanoscale Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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