Oxygen self-supplied upconversion nanoplatform loading cerium oxide for amplified photodynamic therapy of hypoxic tumors

Abstract

Photodynamic therapy (PDT) has been widely used for the preclinical trial of treating various tumors. However, the hypoxic environment of tumors and the limited penetration depth of traditional ultraviolet light...

Control of Luminescence and Interfacial Properties as Perspective for Upconversion Nanoparticles

“…The CeO 2 can decompose H 2 O 2 generated from a tumor to 3 O 2 , which is converted to 1 O 2 by the PS. [94] A major opportunity to improve the therapeutic effect of upconversion systems is to focus on developing multimodal approaches. To give an example, one could imagine an upconversion nanocrystal doped with two activator ions, Er 3+ and Tm 3+ , and two surface functionalities, a drug-release system triggered by Tm 3+ emissions and a PS that is activated by Er 3+ emissions combined with two different types of sensitizers (Yb 3+ and Nd 3+ ).…”

“…The CeO 2 can decompose H 2 O 2 generated from a tumor to 3 O 2 , which is converted to 1 O 2 by the PS. [ 94 ]…”

Schottky heterojunction CeO2@MXene nanosheets with synergistic type I and type II PDT for anti-osteosarcoma

“…[20][21][22] Specific nanomaterials can also reduce H 2 O 2 to produce more toxic ÁOH. 23 A variety of nanomaterials have been reported to relieve cancer hypoxia through chemical reactions that catalyze H 2 O 2 to produce oxygen, such as nanosized calcium dioxide 24 and nanosized manganese dioxide. 25 For example, a study prepared an integrated nanodiagnostic material based on 2D manganese dioxide and an upconversion probe.…”

In Vitro Synergistic Photodynamic, Photothermal, Chemodynamic, and Starvation Therapy Performance of Chlorin e6 Immobilized, Polydopamine-Coated Hollow, Porous Ceria-Based, Hypoxia-Tolerant Nanozymes Carrying a Cascade System

“…40 A Ce6 and BSA-loaded CeO 2 /UCNP composite was synthesized for PDT with hypoxia relief on ID8 cells. 41 GOx and Ce6loaded CeO 2 NPs were also tried for combined PDT/ST by ameliorating hypoxic conditions in HeLa cell culture. 42 CeO 2 nanostructures with a unique redox property based on the cycling between Ce(III) and Ce(IV) oxidation states exhibit CAT-like, peroxidase (POD)-like, and Fenton-like activities.…”

“…Pd1.7 Bi@CeO 2 NSs loaded with ICG were used for PTT/PDT and CDT using 4T1 cells with hypoxia relief . A Ce6 and BSA-loaded CeO 2 /UCNP composite was synthesized for PDT with hypoxia relief on ID8 cells . GOx and Ce6-loaded CeO 2 NPs were also tried for combined PDT/ST by ameliorating hypoxic conditions in HeLa cell culture …”