Oxygen tension‐associated changes on secondary immune response in halothane or isoflurane anesthetized mice

Puig, N; Elena, G; Barragan, J.; Comba, J. O.; Amerio, N

doi:10.1111/j.1399-6576.1995.tb04202.x

Cited by 11 publications

(11 citation statements)

References 6 publications

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“…In response to anaesthetic exposure, humoral parameters, such as the number of immunoglobulin G secreting cells, are altered in animal studies [19,20]. Exposure to low concentrations of volatile anaesthetics seems to inhibit predominantly T-helper cell function [11].…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to low concentrations of volatile anaesthetics seems to inhibit predominantly T-helper cell function [11]. It has been reported that low concentrations of anaesthetics preferentially impair T cell activity, whereas higher concentrations also affect B cells [19,20]. This effect could be explained by impaired T-helper cell activity that adversely affects B cell activity.…”

Section: Discussionmentioning

confidence: 99%

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Neopterin as a marker of immunostimulation: an investigation in anaesthetic workplaces

Gruber

Lirk²,

Amann

et al. 2002

Anaesthesia

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SummaryPersonnel working in operating theatres and recovery rooms are exposed to a variety of noxious substances. The results of studies of the effects of occupational exposure on immune parameters are conflicting. Neopterin is an acknowledged marker of immunostimulation. Urinary neopterin levels of 58 anaesthetists and anaesthetic nurses were measured over a 3-week period. Neopterin analyses were performed using high performance liquid chromatography. Neopterin levels were within the normal range for all subjects. Younger subjects (aged £ 35 years) had significantly higher urinary neopterin concentrations than older subjects (aged > 35 years). The present study is the first to investigate the influence of anaesthetic exposure on neopterin levels. No evidence of immunostimulation was found.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neopterin as a marker of immunostimulation: an investigation in anaesthetic workplaces

Gruber

Lirk²,

Amann

et al. 2002

Anaesthesia

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“…In contrast, neither anesthetic induced dramatic changes of cell membrane plasticity or hypertrophy of the Golgi apparatus, nor did they produce any profound effect on the platelets. Isoflurane shares the halothane-anesthetic mechanism, but displays very low biotransformation and shows no immune response in the same model (Baden and Rice, 1990;Puig et al, 1995;Elena et al, 1997). It has a reduced tendency to cause perturbation of the cell membrane when compared with halothane (Koubi et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

In vivo interaction of pulmonary intravascular macrophages with activated platelets in microvessels of equine lung after multiple exposures to halothane, isoflurane, and thiamylal: A comparative ultrastructural and cytochemical study

Atwal

McDonell

2005

Anat. Rec.

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The pulmonary intravascular macrophages (PIMs) of equines contain a unique electron-dense surface coat that is predominantly composed of lipoproteins. A single exposure of inhalatory halothane causes mobilization of the surface coat into the endocytotic system of the PIMs, followed by expansion of the Golgi apparatus and its enrichment with acid phosphatase. Simultaneously, the cells of the lymphocytic series show hyperplasia in the form of mitotic changes inside the microvascular compartment of the lung. Halothane is known to cause acute and chronic hepatotoxicity because of its biotransformation into trifluoroacytelated polypeptides. The present study was designed to examine the comparative effects of reexposures of inhalatory doses of halothane, isoflurane, and the intravenous barbiturate thiamylal sodium in ponies to evoke a stronger response in the PIMs after four exposures at increasing intervals of 1, 2, and 6 weeks. Ultrastructural and cytochemical evidence is presented that halothane induced translocation of the surface coat into the vacuolar system of the PIMs, followed by expansion of the Golgi apparatus and its enrichment with acid phosphatase. The cell membrane was thrown into extraordinary lamellipodial extensions, which enabled the PIMs to interact with platelets within the narrow confines of the pulmonary capillaries. The relationship between PIMs and platelets developed into large platelet aggregates. Isoflurane and thiamylal sodium did not affect the circulating platelets, although the surface coat was translocated into the endolysosomes in both situations. Although isoflurane is a lipid-soluble inhalant anesthetic similar to halothane, it is subject to very little biotransformation after use and in the present model demonstrates no immune response.

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“…activation. Halothane increases the antibody titre 8 , and, as sevoflurane does, it increases the primary and secondary responses 5,8,9,20,21,27 .…”

Section: Il-6mentioning

confidence: 99%

“…Thus, part of the effect of anaesthetics on the immune system would be due to its action on the well-known immunomodulatory effect of glucocorticoids 3 . Diverse in vitro experiments with human immune cells 4 , ex vivo [5][6][7] , in vivo [8][9][10] or animal models have been used to study the effect of anaesthetic drugs on the immune system. .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2013

OA Anaesthetics

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IntroductionThe immune system protects us from infections through coordinate action of its components. Patients and animals undergoing anaesthesia and surgery show alterations in the immune response. In this paper, we review the effects of some of the most common anaesthetic drugs on the immune system, in particular the effects within 24 hours after their administration, describing their effects on cells and cytokines of the innate and acquired immune system. Discussion As it is difficult to isolate the effects of anaesthetic drugs in the case of surgery, diverse in vitro studies with human immune cells or in vivo with animal models have been used to study the effect of anaesthetic drugs on the immune system. These studies have demonstrated diverse effects, such as changes in immune cell counts and functionality, and on the secretion patterns of diverse cytokines affecting the inflammatory response in the postoperative period. Conclusion Effects of anaesthetic drugs on the immune system are clinically important because the amount and function of the immune cells, as well as the balance between pro-and anti-inflammatory cytokines secretion, are related to postoperative infections and tissue injury.

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Oxygen tension‐associated changes on secondary immune response in halothane or isoflurane anesthetized mice

Cited by 11 publications

References 6 publications

Neopterin as a marker of immunostimulation: an investigation in anaesthetic workplaces

Neopterin as a marker of immunostimulation: an investigation in anaesthetic workplaces

In vivo interaction of pulmonary intravascular macrophages with activated platelets in microvessels of equine lung after multiple exposures to halothane, isoflurane, and thiamylal: A comparative ultrastructural and cytochemical study

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