Oxygen tension regulates osteoblast function

Tuncay, Orhan C.; Ho, Daphne; Barker, Melissa K.

doi:10.1016/s0889-5406(94)70006-0

Cited by 117 publications

(87 citation statements)

References 25 publications

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“…In the case of osteocytes, which are also isolated in matrix remote from blood vessels, it has been proposed that hypoxia may represent a novel mechanotransduction pathway; numbers of hypoxic or HIF-1a-expressing osteocytes are increased markedly in situ in response to mechanical unloading (Dodd et al, 1999;Gross et al, 2001). Diverse responses to hypoxia have been reported for cultured osteoblasts, including: increased proliferation with decreased alkaline phosphatase (ALP) activity and collagen synthesis (Tuncay et al, 1994;Matsuda et al, 1998); decreased proliferation with increased ALP and increased synthesis of vascular endothelial growth factor (VEGF), insulin-like growth factor II (IGF-II), and transforming growth factor b1 (TGF b1) (Steinbrech et al, 1999(Steinbrech et al, , 2000a. Stimulation of osteoblastic VEGF synthesis by hypoxia, an effect mediated by HIF-2a (Akeno et al, , 2002, may represent a basic homeostatic response to low PO 2 , since VEGF is powerfully angiogenic.…”

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confidence: 99%

Hypoxia is a major stimulator of osteoclast formation and bone resorption

Arnett

Gibbons

Utting

et al. 2003

Journal Cellular Physiology

270

204

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Hypoxia is known to act as a general stimulator of cells derived from marrow precursors. We investigated the effect of oxygen tension on the formation and function of osteoclasts, the cells responsible for bore resorption, which are of promonocytic origin. Using 7-and 13-day cultures of mouse marrow cells on ivory discs, we found that reducing oxygen tension from the ambient atmospheric level of 20% by increasing the proportion of nitrogen caused progressive increases in the formation of multinucleated osteoclasts and resorption pits. Peak effects occurred in 2% oxygen, where stimulations of resorption up to 21-fold were measured. Significant stimulations of osteoclast formation and resorption were observed even in severely hypoxic cultures gassed with 0.2% oxygen. Short-term cultures of cells disaggregated from rat bones indicated that hypoxia did not alter the resorptive activity of mature osteoclasts, but reduced their survival or adherence. In 3-day organ cultures of mouse calvarial bones, exposure to 2% oxygen resulted in maximal, fivefold stimulation of osteoclast-mediated calcium release, an effect equivalent to that of prostaglandin E 2 (PGE 2 ), a reference osteolytic agent. Hypoxia also caused a moderate acidosis in calvarial cultures, presumably as a result of increased anaerobic metabolism; this observation is significant because osteoclast activation is dependent on extracellular acidification. Our experiments reveal a previously-overlooked mechanism of considerable potential importance for the regulation of bone destruction. These findings may help explain the bone loss associated with a wide range of pathological states involving local or systemic hypoxia, and emphasize the importance of the vasculature in bone.

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mentioning

confidence: 99%

Hypoxia is a major stimulator of osteoclast formation and bone resorption

Arnett

Gibbons

Utting

et al. 2003

Journal Cellular Physiology

270

204

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“…Previous investigations suggest a triggering role for oxygen tension (an environmental factor) in bone remodeling. Correspondingly, abrupt changes in oxygen availability within the periodontium have been suggested to have a regulatory role in alveolar bone remodeling during tooth movement, 12 similar to that seen in bone growth or fracture healing. Here we created an experimental situation that simulates the movement of teeth in the bone, where bone remodeling is accelerated, in the presence of oxygen tension.…”

Section: Discussionmentioning

confidence: 94%

“…[8][9][10][11] Oxygen tension has a triggering role in bone remodeling. 12 The increase in oxygen tension causes cellular differentiation to osseous tissue, whereas decreased oxygen tension results in cartilage formation. 13 There is a parallelism between the increase in oxygen tension and increase in osteoblastic and osteoclastic activity.…”

Section: Introductionmentioning

confidence: 99%

Effects of Hyperbaric Oxygen during Experimental Tooth Movement

Gökçe

Bengi

Akın

et al. 2008

The Angle Orthodontist

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Objective: To determine the effects of hyperbaric oxygen (HBO) on bone remodeling during orthodontic tooth movement. Materials and Methods: Twenty-four male, adult Sprague Dawley rats were randomly divided into two groups. HBO was administered in the first group, and the second group served as a control. The mandibular first molars were moved mesially by means of Ni-Ti closed coil springs in all groups. Results: Results were evaluated histomorphometrically and the parameters of trabecular bone volume (BV/TV), trabecular bone number (Tr.N), and trabecular separation (Tr.Sep) were evaluated at the interradicular bone area of the mandibular first molars. Increases in BV/TV and Tr.N and decreases in Tr.Sep revealed the osteoblastic activity of HBO. HBO application caused an increase in bone apposition and osteoblastic activity or a decrease in osteoclastic activity. Conclusions: HBO enhanced the bone formation during experimental tooth movement. Therefore, the findings of this study support our hypothesis that osteoblastic activity might be modulated by changes in the environmental oxygen tension.

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“…L'OHB s'accompagne d'une augmentation de la néo-formation osseuse [38][39][40][41] et du remodelage osseux [42][43][44] à travers la stimulation d'une puissante protéine recombinante ostéogénique : la rhBMP-2 (recombinant human bone morphogenetic protein-2) [45]. Au total, l'OHB entraînerait une augmentation de la miné-ralisation et de la densité osseuse [46].…”

Section: Impact De L'ohb Sur Les Onm -Bases Théoriquesunclassified

Intérêt de l’oxygénothérapie hyperbare dans la prévention et le traitement des ostéonécroses des maxillaires dues aux bisphosphonates

Gunepin

Derache

Cathelinaud

et al. 2013

Med Buccale Chir Buccale

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Résumé -Les bisphosphonates (BP) sont des inhibiteurs du remodelage osseux indiqués dans la prise en charge de pathologies malignes (myélome multiple, métastases de tumeurs solides, etc.) et bénignes (ostéoporose, maladie de Paget, etc.). Depuis 2003, un effet indésirable imputé à cette classe de médicaments est apparu dans la littérature : les ostéonécroses des maxillaires (ONM) induites par la prise de BP. Cliniquement, l'ONM se caractérise par une exposition d'os nécrotique qui persiste pendant plus de 8 semaines. En 2007, puis 2009, l'American Association of Oral and Maxillofacial Surgeons (AAOMS) a émis des recommandations destinées aux professionnels de santé pour prévenir et prendre en charge cet effet indésirable. Cependant, l'absence de thérapeutiques efficaces a poussé de nombreux auteurs à tester, en complément des thérapies proposées par l'AAOMS, des traitements expérimentaux au nombre desquels figure l'oxygénothérapie hyperbare (OHB). D'un point de vue théorique, l'étiopathogénie des ONM n'étant pas connue, l'impact de l'OHB sur les mécanismes de survenue de cette pathologie reste hypothétique. D'un point de vue clinique, les avis divergent sur l'intérêt de l'utilisation de l'OHB dans le traitement des ONM. Cependant, les résultats préliminaires de deux essais cliniques contrôlés et randomisés en cours aux Etats-Unis laissent à penser que l'OHB pourrait trouver de nouvelles indications en chirurgie orale dans le traitement mais aussi la prévention des ONM.Abstract -Interest of hyperbaric oxygen therapy in the prevention and treatment of bisphosphonate-related osteonecrosis of the jaws. Bisphosphonates (BP) have been used since 1960s for their capability to alter the mechanism of bone resorption and remodeling. Intravenous (IV) BP are effective in the treatment and management of cancer-related conditions including hypercalcemia of malignancy, skeletal-related events associated with bone metastases in the context of solid tumors such as breast cancer, prostate cancer and lung cancer, and management of lytic lesions in the setting of multiple myeloma. Oral BP are used to treat osteoporosis and osteopenia. In 2003, oral and maxillofacial surgeons first recognized and reported cases of non-healing exposed bone in the maxillofacial region in patients treated with IV bisphosphonates. This adverse effect was called BONJ for bisphosphonate-related osteonecrosis of the jaws. Clinically, BONJ is defined by an exposed bone in the maxillofacial region that has persisted for more than 8 weeks. So far, the etiopathogenesis of BONJ remains

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Oxygen tension regulates osteoblast function

Cited by 117 publications

References 25 publications

Hypoxia is a major stimulator of osteoclast formation and bone resorption

Hypoxia is a major stimulator of osteoclast formation and bone resorption

Effects of Hyperbaric Oxygen during Experimental Tooth Movement

Intérêt de l’oxygénothérapie hyperbare dans la prévention et le traitement des ostéonécroses des maxillaires dues aux bisphosphonates

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