Oxygen therapy for cerebral malaria

Bruce-Hickman, Damian

doi:10.1016/j.tmaid.2011.07.003

Cited by 3 publications

(1 citation statement)

References 87 publications

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“…In terms of cardiovascular dynamics, malaria resulted in significantly reduced blood flow spectral power in the frequency interval associated with cardiac and myogenic activity. This effect is probably associated with the compromised delivery of oxygen and nutrients observed in malaria [4,7]. Furthermore, the lactic acidosis in the malarial state is exacerbated by inadequate removal of metabolic waste products, resulting from increased production of lactic acid by the parasites as well as reduced clearance by the liver [11].…”

Section: Discussionmentioning

confidence: 99%

Phase Coherence Between Cardiovascular Oscillations in Malaria: The Basis for a Possible Diagnostic Test

Abdulhameed

Habib

McClintock

et al. 2021

Understanding Complex Systems

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We show how a non-autonomous dynamics approach using time-resolved analyses of power spectra and phase coherence can help in the noninvasive diagnosis of malaria. The work is based on studying oscillations in blood flow and the variability of the heart and respiratory frequencies. The model used assumes that the heart and respiration are two oscillatory pumps with variable frequencies and that the vascular resistance also changes in an oscillatory manner. Red blood cells circulating through the system deliver oxygen to each cell. Malaria changes the red blood cells so that this delivery is compromised. The oscillatory properties of both pumps are also affected. We quantify the latter and compare three groups of subjects: febrile malaria patients (37); non-febrile malaria patients (10); and healthy controls (51). For each subject, time series of skin blood flow, respiratory effort, cardiac activity (ECG) and skin temperature were recorded simultaneously over an interval of 30 minutes. The oscillatory components within the range 0.005 − 2 Hz were analysed and their degree of coordination throughout the cardiovascular system was assessed by wavelet phase coherence analysis. It is shown that malaria, either febrile or non-febrile, substantially reduces the coordination.

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Section: Discussionmentioning

confidence: 99%

Phase Coherence Between Cardiovascular Oscillations in Malaria: The Basis for a Possible Diagnostic Test

Abdulhameed

Habib

McClintock

et al. 2021

Understanding Complex Systems

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HBO Therapy in Miscellaneous Neurological Disorders

Jain¹

2017

Textbook of Hyperbaric Medicine

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GRP-104 Interactions Between Medicinal Gases and Other Medicinal Products: Development of a Hospital Drug Database

et al. 2013

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Background Oral anticancer drugs still contain some of the most critical issues in terms of right use and compliance. Patients need to be advised and guided concerning dosing schedules, risks and important supportive measures. Package sizes distributed by the pharmaceutical industry often contain more doses than one patient needs especially for short-term stays in the hospital. Purpose Our goal was to dispense patient-individual unit doses of oral anticancer drugs based on individual computerised prescriptions. Materials and MethodsFor this purpose we implemented evidence-based treatment regimens in the prescription software to prevent errors and support the use of standardised treatment plans. Additionally patient information leaflets were created. The first drugs to be computerised in this way were capecitabine and temozolomide. Results Individualised dispensing of oral anticancer drugs allows more extensive pharmaceutical care of these patients. In view of the risks described above oral anticancer drugs have to undergo a pharmaceutical plausibility cheque and the amount has to be found suitable according to the treatment regime before dispensing. Moreover, the available instructions for use e.g. treatment schedules including supportive measures and the patient information brochure improve the information flow and the safe use. Conclusions Due to the positive feedback from the operators we are extending the procedure to all oral anticancer drugs. Results In 2010, adherence to the five key elements was only seen in 3% of prescriptions (n = 68), with an increase to 74% (n = 54) post-chart initiation in 2012 (P = 0.007). Ward-based clinical pharmacists were found to have specified the insulin device in 81% (n = 42) of those prescriptions incorporating a device. Conclusions By incorporating the five key prescribing elements in a specifically designed insulin chart, a statistically significant improvement in insulin prescribing was seen. Individual pharmacists also demonstrated a significant contribution in improving prescribing safety of this high-risk medicine, with an ultimate reduction in error potential and decreased risk of patient harm. References The programme requires the doctor, before prescribing, to review the recorded home medicines. The programme suggests reconciliation for each drug, and the doctor must indicate if he accepts it. The home medicine automatically goes to the hospital prescription if the doctor accepts the suggestion, or he can suspend the drug or accept the therapeutic interchange that the programme offers him.In the case of a drug that is not available in the hospital or for which there is no therapeutic equivalent, the doctor must decide if he suspends it or if he asks the patient to bring it from his home, in which case the medicine is sent to the Pharmacy department to repackage and dispense through a unit dose system.All hospital beds were included in the study (450). Results About 65% of the patients were on drug treatment when they were admitted to hospital. • •The average numbe...

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Oxygen therapy for cerebral malaria

Cited by 3 publications

References 87 publications

Phase Coherence Between Cardiovascular Oscillations in Malaria: The Basis for a Possible Diagnostic Test

Phase Coherence Between Cardiovascular Oscillations in Malaria: The Basis for a Possible Diagnostic Test

HBO Therapy in Miscellaneous Neurological Disorders

GRP-104 Interactions Between Medicinal Gases and Other Medicinal Products: Development of a Hospital Drug Database

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