Oxygen tolerance in patients with acute respiratory failure

Capellier, Gilles; Beuret, Pascal; Clément, G; Depardieu, F.; Ract, Catherine; Régnard, Jean-François; Robert, Dominique; Barale, F

doi:10.1007/s001340050590

Cited by 31 publications

(7 citation statements)

References 25 publications

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“…This damage may be produced by the underlying disease process, the inflammation associated with ARDS or the use of excessive tidal volumes during ventilation 56 while any effects of hyperoxia remain unknown 7…”

Section: Pathophysiologymentioning

confidence: 99%

Diagnosis of pneumothorax in critically ill adults

Rankine

Thomas²,

Fluechter³

2000

Postgraduate Medical Journal

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The diagnosis of pneumothorax is established from the patients' history, physical examination and, where possible, by radiological investigations. Adult respiratory distress syndrome, pneumonia, and trauma are important predictors of pneumothorax, as are various practical procedures including mechanical ventilation, central line insertion, and surgical procedures in the thorax, head, and neck and abdomen. Examination should include an inspection of the ventilator observations and chest drainage systems as well as the patient's cardiovascular and respiratory systems.Radiological diagnosis is normally confined to plain frontal radiographs in the critically ill patient, although lateral images and computed tomography are also important. Situations are described where an abnormal lucency or an apparent lung edge may be confused with a pneumothorax. These may arise from outside the thoracic cavity or from lung abnormalities or abdominal viscera inside the chest. (Postgrad Med J 2000;76:399-404)

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Section: Pathophysiologymentioning

confidence: 99%

Diagnosis of pneumothorax in critically ill adults

Rankine

Thomas²,

Fluechter³

2000

Postgraduate Medical Journal

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“…This median FiO 2 level was equal to 0.70 [IQR 0.6-0.8] in our study. The adjustment of FiO 2 is still a matter of controversy [7,8]. The lung of patients with ARDS might exhibit some relative resistance to prolonged oxygen exposure [7].…”

Section: Dear Editormentioning

confidence: 99%

The best PEEP or the optimal PEEP or the piece PEEP of the mechanical power puzzle?

Briassoulis

Ilia

2022

Crit Care

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“…Supraphysiological concentrations of oxygen in inspired gas (hyperoxia) are frequently required to treat hypoxaemia in patients with ALI [116]. Prolonged exposure to high oxygen levels causes damage in many normal organs and tissues [117].…”

Section: Inspired Oxygen Concentrationmentioning

confidence: 99%

“…It has been shown that if patients with ALI breathe 100% oxygen, an increase in intrapulmonary shunting occurs as a result of the collapse of unstable alveolar units with very low V̇/Q̇ ratios [125]. In a retrospective study over 10 years of 74 patients with acute respiratory failure ventilated continuously with an F I O 2 > 0.9 for at least 48 h, no difference in duration of exposure to this F I O 2 was found between survivors and non‐survivors (5.6 days vs. 5.9 days) [116]. However, on multivariate analysis, exposure to an F I O 2 of > 0.9 was significantly associated with death, presumably as a result of more severe ALI in this group.…”

Section: Inspired Oxygen Concentrationmentioning

confidence: 99%

New aspects of ventilation in acute lung injury

Malarkkan¹,

Snook

Lumb

2003

Anaesthesia

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Summary Recent recognition that artificial ventilation may cause damage to the acutely injured lung has caused renewed interest in ventilation techniques that minimise this potential harm. Many ventilation techniques have proved beneficial in small trials of very specific patient groups, but most have subsequently failed to translate into improved patient outcome in larger trials. An exception to this is ‘protective ventilation’ using reduced tidal volumes (to lower airway pressure) and increased PEEP (to reduce pulmonary collapse). Results of trials of protective ventilation have been encouraging, and the technique should now be adopted more widely. High frequency ventilation, inverse ratio ventilation, prone positioning and inhaled nitric oxide are all techniques that may be considered when, in spite of optimal artificial ventilation, the patient's gas exchange remains dangerously poor. Under these circumstances, the choice of technique is dependent on their availability, local expertise and individual patient needs.

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Oxygen tolerance in patients with acute respiratory failure

Abstract: Thus, our data provide circumstantial evidence that the lungs of patients with acute respiratory failure might exhibit some relative resistance to prolonged oxygen exposure. Therefore, it might be worthwhile carrying out a prospective study of different FIO2 strategies in such patients.

Cited by 31 publications

References 25 publications

Diagnosis of pneumothorax in critically ill adults

Diagnosis of pneumothorax in critically ill adults

The best PEEP or the optimal PEEP or the piece PEEP of the mechanical power puzzle?

New aspects of ventilation in acute lung injury

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