Oxygen‐Tolerant Photoredox Catalysis Triggers Nitric Oxide Release for Antibacterial Applications

Abstract

Photoredox catalysis has emerged as a robust tool for chemical synthesis. However, it remains challenging to implement photoredox catalysis under physiological conditions due to the complex microenvironment and the quenching of photocatalyst by biologically relevant molecules such as oxygen. Here, we report that UV-absorbing N,N'-dinitroso-1,4-phenylenediamine derivatives can be selectively activated by fac-Ir(ppy) 3 photocatalyst within micellar nanoparticles under visible light irradiation (e.g., 500 nm) through photoredox catalysis in aerated aqueous solutions to form quinonediimine (QDI) residues with concomitant release of NO. Notably, the formation of QDI derivatives can actively scavenge the reactive oxygen species generated by fac-Ir(ppy) 3 , thus avoiding oxygen quenching of the photocatalyst. Further, we exemplify that the oxygen-tolerant photoredox catalysis-mediated NO release can not only kill planktonic bacteria in vitro but also efficiently treat MRSA infections in vivo.

Zwitterion-Modified MXene Quantum Dot as a Nanocarrier for Traditional Chinese Medicine Sanguinarine Delivery and Its Application for Photothermal-Chemotherapy Synergistic Antibacterial and Wound Healing

“…Infectious diseases caused by bacteria, viruses, and fungi pose a huge threat to human health. − In the past few decades, although the clinical use of antibiotics has saved many lives, the misuse and abuse of antibiotics have also led to the enhancement of bacterial resistance, environmental pollution, and serious side effects on the human body. − Therefore, researchers are devoting themselves to developing safe and highly effective anti-infection treatment strategies to address the drawbacks of traditional treatment methods at this stage. − Drug therapy is an effective treatment method, but there are common problems, such as low curative effect, poor stability, and short circulation in the body. Therefore, there is an urgent need to develop an efficient antimicrobial drug delivery platform to improve drug utilization. − …”

Fabricating a PDA-NOate@CuS coated NIR-activatable titanium implant to realize simultaneous antiinfection and osseointegration

“…22 Common antibacterial gases include nitric oxide (NO), carbon monoxide (CO), sulfur dioxide (SO 2 ), hydrogen sulfide (H 2 S) and hydrogen (H 2 ). [23][24][25][26][27] Among them, NO has been rapidly developed in the field of biomedicine 28 due to its multiple physiological effects and antibacterial properties in vivo. 29 However, because the release of NO is uncontrolled, the release of more NO will cause its local concentration to become too high and produce cytotoxicity, and the release of less NO will make it insufficient to fight against infection.…”

Photostimulated Extended Nitric Oxide (NO) Release from Water-Soluble Block Copolymer to Enhance Antibacterial Activity

“…Therapy using gasotransmitters (carbon monoxide, sulfur dioxide, and nitric oxide) seems propitious due to their notable impacts on various therapeutic applications, including antibacterial activity. − Nitric oxide (NO) is one of the gasotransmitters predominantly utilized in anticancer, , wound healing, − and antimicrobial activity. , In the body, NO is primarily formulated from l -arginine and exhibits concentration-dependent paradoxical phenomena in various biomedical applications . For example, the endogenous NO of bacteria produced by bacterial nitric oxide synthase (bNOS) increases their survival rate against antibiotics .…”

“…8−10 Nitric oxide (NO) is one of the gasotransmitters predominantly utilized in anticancer, 11,12 wound healing, 13−15 and antimicrobial activity. 16,17 In the body, NO is primarily formulated from L-arginine and exhibits concentration-dependent paradoxical phenomena in various biomedical applications. 18 For example, the endogenous NO of bacteria produced by bacterial nitric oxide synthase (bNOS) increases their survival rate against antibiotics.…”