Oxygen transfer performance of a new Sarns membrane oxygenator

Fried, David W; Bell-Thomson, John

doi:10.1177/026765919200700404

Cited by 14 publications

(6 citation statements)

References 8 publications

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“…[2][3][4][5] The shunt fraction represents the percentage of venous blood which flows through the oxygenator without participating in effective gas exchange. Utilizing this technique, we were able to establish 'normal' or predicted shunt values for several different membrane oxygenators.…”

Section: Introductionmentioning

confidence: 99%

The proposed use of a 'screening test' to assess oxygenator performance

1993

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This study aimed to assess whether the use of the physiological shunt equation could (within the first five minutes of initiating CPB) serve as a 'screen' to differentiate normal and dysfunctional oxygenator performance. If dysfunction severe enough to require replacement was necessary, the normothermic patient could be weaned from CPB and replacement would be carried out under safe, controlled conditions. This technique would require postponing the induction of hypothermia (if used), aortic cross-clamping, and arresting the heart until after this screen was completed. This study demonstrates that a strong negative correlation exists between the degree of blood shunting and the membrane's 0 2 transfer performance (r = -0.874). This relation enables us to predict 0 2 transfer performance when only the shunt fraction is known. Of the 41 oxygenators used in this study, 40 demonstrated normal, or below-normal, shunt fractions. Oxygen transfer performance at or above predicted levels would be anticipated for these oxygenators. One of the 41 oxygenators had mildly elevated shunt fractions, which we predicted would be associated with mild 0 2 transfer dysfunction. Based on the performance screen worksheet we created, replacement was not necessary since the oxygenator maintained high levels of 0 2 transfer in reserve despite its marginal performance dysfunction. Assessment of oxygenator performance dysfunction in this earliest phase of CPB would greatly reduce the incidence of emergency oxygenator replacement secondary to actual or perceived oxygenator failure later in the course of the procedure.

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Section: Introductionmentioning

confidence: 99%

The proposed use of a 'screening test' to assess oxygenator performance

1993

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“…Again, there is a group of oxygenators with a lower resistance, the HF 5400 (2.4-1.87 mmHg/min/ml 02), the AFFI-NITY (2.63-1.87 mmHg/min/ml 02), followed by a group with a higher resistance, the OXIM 11-34 (2.72-2.45 (8.7-10.9%), the CM 50 (2.4-11.9%), the UNIVOX (8.9-13.3%), the OXIM 11-34 (17. [3][4][5][6][7][8][9][10][11][12][13][14][15].5%) and the SAFE 11 (9.8-16.1%). …”

Section: Resultsmentioning

confidence: 99%

Clinical evaluation of the oxygenation capacity and controllability of 15 commercially available membrane oxygenators during alpha-stat regulated hypothermic cardiopulmonary bypass

Stinkens¹,

Himpe²,

Thyssen³

et al. 1996

Perfusion

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Oxygenation performance was tested in 15 membrane oxygenators by calculating the resistance for oxygenation (R) and the calculation of oxygen transferred versus FiO2. The clinical data reveal that the SARNS Turbo 440 (36.7-51.9%), the AFFINITY (37.2-50.1%) and the HF 5400 (37.5-52.3%) are the oxygenators with the lowest FiO2 settings for comparable amounts of oxygen transferred during hypothermia and during normothermia followed by MAXIMA Plus (39.1-55.8%), MAXIMA Plus PRF (39.1-56.2%), CAPIOX SX 18 (39.7-61.2%), MONOLYTH (43.0-61.3%), OXIM 11-34 (44.1-63.9%), COBE Duo (44.7-64.9%), COBE Optima (47.4-66.4%), COMPACTFLO (48.3-65.3%), SAFE II (49.0-67.6%), UNIVOX (49.8-71.3%), MAXIMA (50.2-70.1%) and the CM 50 (58.6-77.0%). Similar results were found by calculation of R. HF 5400 (2.41-1.87 mmHg/min/ml O2), AFFINITY (2.63-1.87 mmHg/min/ml O2). OXIM II-34 (2.72-2.45 mmHg/min/ml O2), MAXIMA Plus PRF (2.75-2.07 mmHg/min/ ml O2), COBE Optima (2.83-2.13 mmHg/min/ml O2), UNIVOX (2.84-2.17 mmHg/min/ml O2), MONOLYTH (2.89-2.24 mmHg/min/ml O2), SARNS Turbo 440 (3.03-2.12 mmHg/min/ml O2), MAXIMA Plus (3.09-2.28 mmHg/min/ml O2), SAFE 11 (3.19-2.50 mmHg/min/ml O2), CAPIOX SX 18 (3.27-2.44 mmHg/ min/ml O2), COMPACTFLO (3.41-2.50 mmHg/min/ml O2), MAXIMA (3.53-2.72 mmHg/min/ml O2), COBE Duo (3.57-2.71 mmHg/min/ml O2) and the CM 50 (3.53-2.72 mmHg/min/ml O2). As a measure of controllability of oxygenation, the coefficient of variation on the FiO2 ordered on the normothermic blood samples was used, giving as a result CAPIOX SX 18 (2.9-2.5%), AFFINITY (3.6-3.5%), COBE Duo (4.3-2.9%), HF 5400 (5.7-4.7%), MAXIMA Plus (8.1-5.4%), COMPACTFLO (8.2-5.0%), MONOLYTH (8.3-4.0%), MAXIMA (8.7-3.4%), COBE Optima (9.6-6.8%), SARNS Turbo 440 (10.1-7.3%), MAXIMA Plus PRF (10.9-8.7%), CM 50 (11.9-2.4%), UNIVOX (13.3-8.9%), OXIM 11-34 (15.5-17.3%) and the SAFE II (16.1-9.8%). The low FiO2 settings and the lower resistance for oxygenation are an indication of the reserve capacity of the oxygenators whose importance is proven by clinical data of emergency perfusions on patients under full resuscitation.

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“…In comparison, average shunt fractions of 21.75% for the Terumo Capiox SX 18R remained unchanged to past generation oxygenators. Last generation oxygenators had shunt fractions of 27.0-15.6% (11,15). Reviewing the combined shunt fractions, most shunt fractions were near the average and did not vary with blood flow rates as past designs in oxygenators have revealed (Figure 2) (11).…”

Section: Slopementioning

confidence: 87%

“…Last generation oxygenators had shunt fractions of 27.0-15.6% (11,15). Reviewing the combined shunt fractions, most shunt fractions were near the average and did not vary with blood flow rates as past designs in oxygenators have revealed (Figure 2) (11). When reviewing each oxygenator individually many shunt fractions were inconsistent in relation to Qb (Figure 3).…”

Section: Slopementioning

confidence: 95%

A Clinical Evaluation of the Terumo Capiox SX1BR Hollow Fiber Oxygenator

Dekkers,

Lawson,

Smigla

et al. 1995

J Extra Corpor Technol

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The Terumo Capiox SX18R is a commercially available, low prime, reverse phase, hollow fiber membrane oxygenator. The oxygenator consists of a 1.8 m2 microporous polypropylene hollow fiber bundle, a 2200 cm2 tubular stainless steel heat exchanger. and an open hard shell venous reservoir with integral cardiotomy filter. The Terumo Capiox SX 18R oxygenator was evaluated to determine its clinical oxygenating performance. Blood samples were drawn from 25 patients yielding 114 data points. The following parameters were recorded: blood flow, cardiac index, gas flow, gas to blood flow ratio, and oxygen fraction. Samples were assayed for hematocrit, hemoglobin, arterial and venous blood gas values, and venous oxygen saturation. The data and assay results were used to calculate arterial, venous, and membrane gas oxygen content, oxygen transfer, shunt fraction, and oxygen diffusion capacity. The Terumo Capiox SX18R oxygenator performed adequately with sufficient oxygen transfer reserve and carbon dioxide clearance under a variety of clinical conditions for the tested population.

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Oxygen transfer performance of a new Sarns membrane oxygenator

Cited by 14 publications

References 8 publications

The proposed use of a 'screening test' to assess oxygenator performance

The proposed use of a 'screening test' to assess oxygenator performance

Clinical evaluation of the oxygenation capacity and controllability of 15 commercially available membrane oxygenators during alpha-stat regulated hypothermic cardiopulmonary bypass

A Clinical Evaluation of the Terumo Capiox SX1BR Hollow Fiber Oxygenator

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