Oxygen Transport in Peripheral Arterial Occlusive Disease: Effects of Calf Blood Dialysate

Abstract

The obvious relationship of arterial blood flow to tissue hypoxia has led to the relative neglect of secondary mechanisms that might influence the functional and morphologic consequences of major vessel obstruction. Oxygen diffusion through capillaries, both locally and systemically, may be disturbed in subjects with chronic local ischemia. Follow-up data after a double-blind, placebo-controlled evaluation of the effect of treatment with a calf blood dialysate confirm that such treatment may alleviate the consequences of peripheral arterial obstructive disease even though there is no improvement in blood flow through the arterial system involved.

The Effectiveness of the Haemodialysate Solcoseryl® for Second‐Intention Wound Healing in Horses and Ponies

“…Ponies show a strong but short inflammatory response and a fast and pronounced wound contraction, whereas horses show a weak but protracted inflammatory response, less contraction and consequently more epithelialization ( Wilmink et al, 1999a,b). In the literature, HD appears to be most effective when the wound healing process is impaired, or when in vitro, culture conditions are suboptimal ( Knudsen et al, 1982; Marichy and Eyraud, 1984; Biland et al, 1985; Rossano et al, 1990; Rossano et al, 1993; Spessoto et al, 1993; Miltenburger et al, 1994). In this study, HD also affected the impaired phases of healing more than it affected the other phases.…”

“…HD improves second‐intention wound healing in several species by interacting with different steps of the wound healing cascade. HD stimulates the healing of ulcers and burns in humans ( Knudsen et al, 1982; Marichy and Eyraud, 1984; Biland et al, 1985; Rossano et al, 1990; Rossano et al, 1993) and also the healing of experimental wounds in other species, such as rats ( Isler et al, 1991a; Isler et al, 1991b), pigs (Hoekstra, personal communication) and guinea‐pigs ( Laaf, 1993). In vitro , HD stimulates cell metabolism, growth and migration ( Riede et al, 1975; Niinikoski and Renvall, 1979; Fraefel et al, 1985; Dri et al, 1989; Fabbro et al, 1992; Schreier et al, 1993; Spessoto et al, 1993; Miltenburger et al, 1994).…”