Oxygen Transport to Tissue XXXI

Correlation between asymmetry of spontaneous oscillation of hemodynamic changes in the prefrontal cortex and anxiety levels: a near-infrared spectroscopy study

“…NIRS findings indicate that right dominant PFC activity during mental arithmetic tasks was associated with greater levels of activity of the neuroendocrine and autonomic nervous systems compared with those of left dominant PFC activity. [16][17][18][19]26 However, it is not yet clear whether right/left asymmetry of PFC activity at rest correlates with the stress responses of the neuroendocrine and autonomic nervous systems. Further studies are needed to clarify these issues.…”

“…In order to determine left/right asymmetry of PFC activity during the stress task, we calculated a laterality index (LIA) for the oxy-Hb concentration changes ½ðright-leftÞ∕ðright þ leftÞ; LIA > 0 indicates greater activity of the right PFC, while LIA < 0 indicates greater activity of the left PFC. [16][17][18][19] …”

“…Both young and aged groups showed a significant positive correlation between LIR and STAI-1 score, and statistical analysis using Fisher's z-transformation suggested that aging has no significant effect on the correlation (see Appendix). Sakatani et al 19 evaluated the effect of aging on the correlation between LIA (i.e., LI of PFC activity during mental arithmetic tasks) and heart rate changes during task performance. They found that right PFC activity predominantly modulates sympathetic effects during the task in both young and aged groups, suggesting that aging did not affect the laterality of PFC activity in modulation of autonomic nervous system function.…”

“…The subjects were asked to consecutively subtract a two-digit number from a four-digit number (e.g., 1022-13) as quickly as possible for 60 s. This mental arithmetic task has previously been used to investigate mental stress-induced PFC activity. [16][17][18][19] In order to investigate the relationships between LIR and during the task and STAI scores, we examined the correlations between them by means of Pearson's product-moment correlation or Spearman's rank-order correlation analysis.…”

“…Significant positive relationships have been found between LIA and somatic and psychological stress responses. [16][17][18][19]26 A number of studies have demonstrated correlations between electrical neural activity and change in blood oxygenation measured by NIRS. Simultaneous recording and analysis of NIRS and visual-evoked potential signals in humans has indicated that there is a strong linear correlation between hemodynamic changes and evoked potential amplitude.…”