Oxygen uptake efficiency slope: an index of exercise performance and cardiopulmonary reserve requiring only submaximal exercise

Hollenberg, Milton; Tager, Ira B.

doi:10.1016/s0735-1097(00)00691-4

Cited by 252 publications

(342 citation statements)

References 12 publications

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“…OUES values were significantly lower in depleted patients and strongly related to FFM in all patients. The OUES represents the rate of increase of V O 2 in response to a given V E during incremental exercise, indicating how effectively oxygen is extracted and taken into the body 36 ; it is considered as an objective measure of cardiorespiratory and muscular fitness. 37 Last, HRR, a marker of the cardiac autonomic function and a powerful predictor of mortality in the general population, 22 was significantly lower in our depleted patients (8.7 beats/min on average).…”

Section: Discussionmentioning

confidence: 99%

Fat-Free Mass Depletion Is Associated With Poor Exercise Capacity Irrespective of Dynamic Hyperinflation in COPD Patients

et al. 2013

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BACKGROUND:In patients with COPD, we investigated the effect of the fat-free mass (FFM) on maximal exercise capacity and the relationship with changes in operational lung volumes during exercise. METHODS: In a cross-sectional study 57 patients (16 females; age 65 ؎ 8 y) were consecutively assessed by resting lung function, symptom-limited cardiopulmonary exercise test, and body composition by means of bioelectrical impedance analysis to measure the FFM index (FFMI; in kilograms per square meter). RESULTS: Patients were categorized as depleted (n ‫؍‬ 14) or nondepleted (n ‫؍‬ 43) according to FFMI. No significant difference in gender, age, and resting lung function was found between depleted and nondepleted patients. When compared with nondepleted COPD patients, the depleted COPD patients had a significantly lower O 2 uptake at the peak of exercise and at anaerobic threshold as well as at peak oxygen pulse, oxygen uptake efficiency slope (OUES), and heart rate recovery (HRR) (P < .05 for all comparisons), but similar inspiratory capacity/total lung capacity at the peak of exercise. Moreover, they also reported significantly higher leg fatigue (P < .05), but not dyspnea on exertion. In all patients, significant correlations (P < .01) were found between FFMI and peak oxygen pulse, OUES, HRR, and leg fatigue. CONCLUSIONS: This study shows that FFM depletion plays a part in the reduction of exercise capacity in COPD patients, regardless of dynamic hyperinflation, and is strictly associated with poor cardiovascular response to exercise and to leg fatigue, but not with dyspnea.

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Section: Discussionmentioning

confidence: 99%

Fat-Free Mass Depletion Is Associated With Poor Exercise Capacity Irrespective of Dynamic Hyperinflation in COPD Patients

et al. 2013

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“…Oxygen uptake efficiency slope and VE/VCO 2 slope were calculated as previously described. 5,7 In 20 patients, the OUES could not be exactly calculated due to technical limitations.…”

Section: Cardiopulmonary Exercise Testingmentioning

confidence: 99%

“…2 Evaluation of peak exercise capacity has important prognostic implications. 3 However, as many chronic heart failure (CHF) patients are not able to perform maximal exercise, parameters obtained during submaximal exercise such as the ratio of ventilation and CO 2 elimination (VE/VCO 2 slope) 4 or oxygen uptake efficiency slope (OUES) 5,6 have been investigated and were shown to improve the accuracy of CPET in evaluating CHF patients. However, several studies yielded conflicting results with respect to the prognostic power of submaximal and maximal exercise parameters.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Seattle Heart Failure Model and Cardiopulmonary Exercise Capacity for Prediction of Death in Patients With Chronic Ischemic Heart Failure and Intracoronary Progenitor Cell Application

Honold

Rosa

Spyridopoulos

et al. 2013

Clinical Cardiology

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Background: Despite many therapeutic advances, the prognosis of patients with chronic heart failure (CHF) remains poor. Therefore, reliable identification of high-risk patients with poor prognosis is of utmost importance. Cardiopulmonary exercise testing (CPET) provides important prognostic information by peak O 2 uptake (peak VO 2 ), maximal oxygen pulse (O 2 Pmax), O 2 uptake efficiency slope (OUES), and VE/VCO 2 slope (VE/VCO 2 ). A different approach for prognostic assessment is the Seattle Heart Failure Model (SHFM), which is based on clinical data and calculates the estimated annual mortality. Hypothesis: Comparison of the prognostic value of the Seattle Heart Failure Score and cardiopulmonary excercis testing in patients with chronic heart failure. Methods: One hundred fifty-seven patients with ischemic heart failure and recent intracoronary progenitor cell application were analyzed for mortality during a follow-up of 4 years. CPET (peak VO 2 , O 2 Pmax, OUES, VE/VCO 2 ) was performed in all patients at baseline. The SHFM score was calculated for every patient, with data obtained at the time of CPET. Results: During follow-up, 24 patients died (15.2%). Nonsurvivors had significantly worse initial CPET results and a higher SHFM score compared to survivors. Receiver operating characteristics curve analysis of sensitivity and specificity revealed the largest area under the curve value for the SHFM score, followed by VE/VCO 2 slope. Kaplan Meier analysis using cutoff points of SHFM and VE/VCO 2 slope with highest sensitivity and specificity resulted in significant discrimination of survivors and nonsurvivors. By multivariate analysis, only the SHFM score persisted as independent predictor of mortality in these patients. Conclusions: These data indicate superior prognostic power of the SHFM score compared to CPET in patients with chronic ischemic heart failure. IntroductionHeart failure is associated with high mortality rates, prolonged and repeated hospitalizations, and enormous implications for healthcare systems. Despite novel therapeutic options like revascularization, device therapy, and pharmacotherapy, the prevalence and incidence of chronic heart failure continued to increase over the last decades. 1 The identification of high-risk patients requires objective assessment of mortality risk. Cardiopulmonary exercise

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“…The OUES is determined by the slope of the linear relationship between oxygen consumption (VO 2 ) and the logarithmic transformation of the Ventilation (VE)values during an incremental exercise test. Its determination can be made using total (i.e., 100%) or partial (e.g., 80%) gas exchange data collected during the incremental test [12,13].…”

Section: Introductionmentioning

confidence: 99%

Maximal and submaximal oxygen uptake efficiency slope: influence of cardiorespiratory variables and maximal dynamic strength

Pasqua¹,

Damasceno²,

Lima‐Silva³

et al. 2017

Pulm Crit Care Med

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Objective: The purpose of this study was to investigate if the OUES is determined by the same factors when calculated with VO 2 and VE values throughout the incremental test (OUES 100 ) or using values until 80% of the VO 2 max (OUES 80 ).Methods: 116 healthy male individuals performed a maximal incremental test, two constant-speed tests and a maximal dynamic strength test.Results: OUES 100 and OUES 80 were significantly correlated (r = 0.964; P < 0.001). VO 2 max was the main determinant factor for both OUES 100 and OUES 80 . Additionally, maximal heart rate (HRmax) and maximal dynamic strength (1RM) were the other variables selected for the two models as secondary variables. However, the importances of them were inversed, with the HRmax being the second determinant of the OUES 80 , while 1RM the second determinant for OUES 100 . The running economy, ventilatory threshold and respiratory compensation point were not selected for the models (P > 0.05). Conclusions:Our results suggest that the OUES 80 might satisfactorily replace maximal variables in aerobic fitness evaluations without maximal effort requirement. VO 2 max seems to be the main factor determining oxygen uptake efficiency slope, regardless the range (maximal or submaximal) used to determine. Otherwise, the muscle strength plays a more important role to the oxygen uptake efficiency considering maximal intensities, while the cardiovascular system seems to more strongly influence the oxygen uptake efficiency only until submaximal intensities.

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Oxygen uptake efficiency slope: an index of exercise performance and cardiopulmonary reserve requiring only submaximal exercise

Cited by 252 publications

References 12 publications

Fat-Free Mass Depletion Is Associated With Poor Exercise Capacity Irrespective of Dynamic Hyperinflation in COPD Patients

Fat-Free Mass Depletion Is Associated With Poor Exercise Capacity Irrespective of Dynamic Hyperinflation in COPD Patients

Comparison of the Seattle Heart Failure Model and Cardiopulmonary Exercise Capacity for Prediction of Death in Patients With Chronic Ischemic Heart Failure and Intracoronary Progenitor Cell Application

Maximal and submaximal oxygen uptake efficiency slope: influence of cardiorespiratory variables and maximal dynamic strength

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