Abstract-This paper investigates the modelling of oxygen consumption (VO 2 ) response to jogging exercise on treadmill. Unlike most of the previous methods, which often use simple parametric models, e.g., first order linear time invariant model, this study applied a nonparametric kernel based regularised method to estimate VO 2 to address the ill-conditioned modelling problem and achieve accurate estimation. In particular, it is worthy to be noted that the selection of kernels will affect the results for different modelling scenarios. Therefore, in this research, both radial basis kernel and stable spline kernel were selected for testing. In order to select the favourable kernel for this system, a simulation related to VO 2 -jogging speed was carried out. The results of simulation indicated that spline kernel can achieve higher accuracy comparing to radial basis function kernel. Experimentally, the kernel based estimation method and spline kernel were tested using six participants. From the results, an average impulse response is obtained. It showed the VO 2 estimation, based on the average finite impulse response, is fitted well to the six observations collected from the participants.