Oxygenative Cleavage of Chlorocatechols with Molecular Oxygen Catalyzed by Non-Heme Iron(III) Complexes and Its Relevance to Chlorocatechol Dioxygenases

Various porphyrin-o-quinones 1−8 were prepared as model compounds for electron transfer reactions. The synthesis of these compounds could only be accomplished by using oquinone components stabilized by sterically demanding substituents in the o,oЈ-positions and by using protected catechol aldehydes for the initial porphyrin condensation step. The stability of the target compounds strongly depends on the steric influence of substituents on the o-quinone, which are necessary to stabilize the o-quinones. To test this steric influence we synthesized the porphyrin-o-quinones both without and with methyl and tert-butyl groups and investigated the influence of the bridging position on the reactivity. The 1 Hand 13 C-NMR spectroscopic characteristics of all compounds

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Peroxidase‐Like Activity of Cupric Oxide Nanoparticle

Wei

et al. 2011

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Almost all processes in a biological cell need enzymes to occur at significant rates. Since enzymes are selective for their substrates and speed up only a few reactions from among many possibilities, the set of enzymes made in a cell determines which metabolic pathways occur in that cell. Besides their fundamental importance, natural enzymes also have significant practical applications in medicine, chemical industry, food processing, and agriculture due to their excellent properties, such as high substrate specificities and high efficiency under mild conditions. However, natural enzymes also bear some serious disadvantages to limit their practical applications. In general, natural enzymes, which are globular proteins, can be digested by proteases. Like all proteins, the secondary, tertiary, and quaternary levels of enzyme structure are maintained by weak, noncovalent forces and can be easily disrupted by environmental changes, such as heating or chemical denaturants, which leading to the loss of their catalytic activity. Furthermore, preparation, purification, and storage of natural enzymes are usually time-consuming and expensive.

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Oxygenative Cleavage of Chlorocatechols with Molecular Oxygen Catalyzed by Non-Heme Iron(III) Complexes and Its Relevance to Chlorocatechol Dioxygenases

Cited by 48 publications

References 19 publications

Tris(2-pyridylmethyl)amine

Tris(2-pyridylmethyl)amine

Porphyrin-o-quinones as Model Systems for Electron Transfer and Catecholase Reactions

Peroxidase‐Like Activity of Cupric Oxide Nanoparticle

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