Oxygenators for Extracorporeal Circulation

Beckley, P.; Holt, David W.; Tallman, Richard D.

doi:10.1007/978-1-4612-2484-6_10

Cited by 10 publications

(9 citation statements)

References 111 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, a 1–2 m 2 surface area is required to sufficiently transfer CO 2 through the membrane [45,46,47,48]. A surface area of this size lacks the practicalities of functioning effectively within the human body [49,50].…”

Section: Artificial Lungsmentioning

confidence: 99%

“…As of now, the main issue preventing effective artificial lungs concerns inadequate transfer of CO 2 per square inch across the polymetric hollow fiber membranes (HFM) present within this technology. Currently, a 1–2 m 2 surface area is required to sufficiently transfer CO 2 through the membrane [ 45 , 46 , 47 , 48 ]. A surface area of this size lacks the practicalities of functioning effectively within the human body [ 49 , 50 ].…”

Section: Artificial Lungsmentioning

confidence: 99%

See 1 more Smart Citation

Carbonic Anhydrases and Their Biotechnological Applications

et al. 2013

View full text Add to dashboard Cite

The carbonic anhydrases (CAs) are mostly zinc-containing metalloenzymes which catalyze the reversible hydration/dehydration of carbon dioxide/bicarbonate. The CAs have been extensively studied because of their broad physiological importance in all kingdoms of life and clinical relevance as drug targets. In particular, human CA isoform II (HCA II) has a catalytic efficiency of 108 M−1 s−1, approaching the diffusion limit. The high catalytic rate, relatively simple procedure of expression and purification, relative stability and extensive biophysical studies of HCA II has made it an exciting candidate to be incorporated into various biomedical applications such as artificial lungs, biosensors and CO2 sequestration systems, among others. This review highlights the current state of these applications, lists their advantages and limitations, and discusses their future development.

show abstract

Section: Artificial Lungsmentioning

confidence: 99%

Section: Artificial Lungsmentioning

confidence: 99%

Carbonic Anhydrases and Their Biotechnological Applications

et al. 2013

View full text Add to dashboard Cite

show abstract

“…During cardiopulmonary bypass and extracorporeal life support, reduction of the sweep gas flow rate is used to prevent hypocapnia and respiratory alkalosis (2). Arterial P co 2 is controlled by adjusting the sweep gas flow rate, typically between 5 and 10 L/min (3), and adding up to 5% CO 2 to the sweep gas (2,4). Currently, the flow dependence of CO 2 exchange is understood only at a qualitative level.…”

mentioning

confidence: 99%

Validation of a Model for Flow‐Dependent Carbon Dioxide Exchange in Artificial Lungs

Hout¹,

Hattler

Federspiel

2000

Artificial Organs

View full text Add to dashboard Cite

The exchange rate of CO2 in artificial lungs depends on the sweep gas flow rate. Control of the amount of CO2 removed by an artificial lung requires quantitative knowledge of the flow dependence. A simple model of the dependence of CO2 exchange on sweep gas flow rate in artificial lungs has been previously presented (1). For a given partial pressure of CO2 in the blood phase, sweep gas flow rate, and CO2 exchange rate, the model indicates how close the CO2 exchange rate is to the maximum level attainable by the artificial lung. The focus of this study was to validate the model experimentally by testing 2 commercial artificial lungs in an in vitro test loop. The CO2 exchange rate for each artificial lung was measured over a range of sweep gas flow rates. Linear regression was used to fit the data to the model and estimate the maximum possible CO2 exchange rate and the average water-side PCO2 (PCO2w). The difference between the measured and regressed values of PCO2w was used as an indicator of the ability of the model to quantitatively predict the dependence of CO2 exchange on gas flow rate. This difference was less than 5% for each experiment, indicating that the model can be used to guide control of CO2 exchange rates in artificial lungs.

show abstract

“…There are several obstructions with available artificial lungs/respiratory assist devices because the main material used are polymeric hollow fibers membranes (HFMs) for the transportations between blood/ biological material and gas pathways. However, these have caused major concern with an accumulation of fouling [4]. The membrane oxygenator is commonly utilized worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…It is also reported that PSF has some defects in hematological application, such as its hydrophobic nature [6,7]. Fouling leads to blockage of the membranes porosity [4,8,9]. Hydrogen bonding, hydrophobic, electrostatic, and van der Waals interactions that occur between the membrane surface and biological foulant, were the culprits of membranes fouling [10].…”

Section: Introductionmentioning

confidence: 99%

Applying a Hydrophilic Modified Hollow Fiber Membrane to Reduce Fouling in Artificial Lungs

Alshammari

Alazmi

Veettil³

2021

Separations

View full text Add to dashboard Cite

Membranes for use in high gas exchange lung applications are riddled with fouling. The goal of this research is to create a membrane that can function in an artificial lung until the actual lung becomes available for the patient. The design of the artificial lung is based on new hollow fiber membranes (HFMs), due to which the current devices have short and limited periods of low fouling. By successfully modifying membranes with attached peptoids, low fouling can be achieved for longer periods of time. Hydrophilic modification of porous polysulfone (PSF) membranes can be achieved gradually by polydopamine (PSU-PDA) and peptoid (PSU-PDA-NMEG5). Polysulfone (PSU-BSA-35Mg), polysulfone polydopamine (PSUPDA-BSA-35Mg) and polysulfone polydopamine peptoid (PSU-PDA-NMEG5-BSA35Mg) were tested by potting into the new design of gas exchange modules. Both surfaces of the modified membranes were found to be highly resistant to protein fouling permanently. The use of different peptoids can facilitate optimization of the low fouling on the membrane surface, thereby allowing membranes to be run for significantly longer time periods than has been currently achieved.

show abstract

Oxygenators for Extracorporeal Circulation

Cited by 10 publications

References 111 publications

Carbonic Anhydrases and Their Biotechnological Applications

Carbonic Anhydrases and Their Biotechnological Applications

Validation of a Model for Flow‐Dependent Carbon Dioxide Exchange in Artificial Lungs

Applying a Hydrophilic Modified Hollow Fiber Membrane to Reduce Fouling in Artificial Lungs

Contact Info

Product

Resources

About