Oxylipin concentrations in bovine corpora lutea during maternal recognition of pregnancy

Owen, M. P. T.; Northrop, Emmalee J.; Rich, Jerica J.J.; Perry, George A.; Messman, Riley D; Dinh, Thu; McCarty, Kathleen M.; Yang, Jun; Wan, Debin; Lemley, Caleb O

doi:10.1016/j.theriogenology.2019.10.003

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…9,10-DiHODE is an ALA-derived dihydroxy fatty acid produced via the CYP pathway. It has been associated with pregnancy in analyses of bovine corpora lutea [27]. Furthermore, CYP products (together with LOX products) have been recognized as the most prominent among the oxylipins for identifying overall and spontaneous preterm birth [28], although 9,10-DiHODE was not included in that study.…”

Section: Discussionmentioning

confidence: 99%

Plasma oxylipin levels associated with preterm birth in preterm labor✰

Svenvik

Raffetseder

Brudin

et al. 2021

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Section: Discussionmentioning

confidence: 99%

Plasma oxylipin levels associated with preterm birth in preterm labor✰

Svenvik

Raffetseder

Brudin

et al. 2021

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“…Thus, 9,10-DiHODE, which is an ALA-derived dihydroxy fatty acid produced via the CYP pathway, seemingly has a protective effect in relation to both PTB <34 weeks of gestation and to delivery within 48 hours. 9,10-DiHODE has previously been associated with pregnancy in analyses of bovine corpora lutea 206 . Interestingly, in a prospective study by Aung et al on asymptomatic women, several CYP products (together with LOX products) had best discriminative capacity among the oxylipins for overall and sPTB <37 weeks of gestation 207 , although 9,10-DiHODE was not included in that study.…”

Section: Associations Between the Oxylipins 910-dihode 1112-dihetre 8-hete And Preterm Birthmentioning

confidence: 97%

Prediction of Spontaneous Preterm Birth : Clinical and Immunological Aspects

Svenvik

2021

Linköping University Medical Dissertations

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Background: Preterm birth (PTB), defined as birth before 37 weeks of gestation, accounts for most neonatal death and morbidity. Accurate prediction is a pre-requisite for the prevention and proper management of PTB. However, methods for prediction are unsatisfactory, although sonographic cervical length has a moderate predictive value. For clinical utility, adding a biomarker could increase the predictive accuracy. The immune system has an important regulatory role during pregnancy. Thus, presumptive predictive biomarkers may be searched for among immune-related molecules, such as cytokines, chemokines and other inflammation-associated mediators.The aims of this thesis were to identify clinical risk factors and immunological prediction markers for PTB, both in women at increased risk of PTB because of preterm labour (PTL) or preterm prelabour rupture of the membranes (PPROM), and in asymptomatic women in early pregnancy. An additional aim was to explore immune reaction patterns in PTL and PPROM compared to normal pregnancy. Material and methods:In a retrospective registry study, including 20,643 women who delivered during a five-year period, risk factors for Apgar score <7 at five minutes and risk factors for PTB <32 weeks were investigated using univariate and multivariate logistic regression. Furthermore, in a multi-centre mixed case-control and prospective cohort study of women with PTL <34 weeks of gestation (n=80), PPROM (n=40), as well as antenatal controls (n=44) and controls in labour at term (n=40), plasma levels of cytokines and chemokines representing different types of immune responses were analysed with a multiplex bead assay. In addition, an extended protein analysis exploring 92 inflammation-associated plasma proteins using proximity extension assay (PEA) was performed, as well as analysis of 67 different oxylipins by liquid chromatography coupled to tandem mass spectrometry. Finally, the PEA technique was used also to explore plasma proteins in a case-control study including 46 women with PTB and 46 women with normal pregnancies and delivery at term. Results and conclusions:A number of partly preventable clinical risk factors for PTB <32 weeks were identified, for example smoking (odds ratio (OR) 1.61 (95% confidence interval (CI) 1.07-2.41)); preeclampsia )); and multiple gestation (OR 15 (95% CI 10-24)). The most evident risk factor for low Apgar scores was PTB; the more preterm the higher the risk. This provides important information for health care professionals, and offers motivations for preventive strategies regarding smoking cessation.

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“…Several of these oxylipins have been associated with pregnancy and gestation. 9,10-and 15,16-DiHODE have been found at higher concentrations in the corpus lutea in pregnant cattle [158], and lower levels of 9,10-DiHODE have been associated with an increase in preterm delivery prior to 34 weeks [159], but the implications of this have not been determined.…”

mentioning

confidence: 99%

Detoxification Cytochrome P450s (CYPs) in Families 1–3 Produce Functional Oxylipins from Polyunsaturated Fatty Acids

Eccles

Baldwin

2022

Cells

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This manuscript reviews the CYP-mediated production of oxylipins and the current known function of these diverse set of oxylipins with emphasis on the detoxification CYPs in families 1–3. Our knowledge of oxylipin function has greatly increased over the past 3–7 years with new theories on stability and function. This includes a significant amount of new information on oxylipins produced from linoleic acid (LA) and the omega-3 PUFA-derived oxylipins such as α-linolenic acid (ALA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). However, there is still a lack of knowledge regarding the primary CYP responsible for producing specific oxylipins, and a lack of mechanistic insight for some clinical associations between outcomes and oxylipin levels. In addition, the role of CYPs in the production of oxylipins as signaling molecules for obesity, energy utilization, and development have increased greatly with potential interactions between diet, endocrinology, and pharmacology/toxicology due to nuclear receptor mediated CYP induction, CYP inhibition, and receptor interactions/crosstalk. The potential for diet-diet and diet-drug/chemical interactions is high given that these promiscuous CYPs metabolize a plethora of different endogenous and exogenous chemicals.

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Oxylipin concentrations in bovine corpora lutea during maternal recognition of pregnancy

Cited by 6 publications

References 27 publications

Plasma oxylipin levels associated with preterm birth in preterm labor✰

Plasma oxylipin levels associated with preterm birth in preterm labor✰

Prediction of Spontaneous Preterm Birth : Clinical and Immunological Aspects

Detoxification Cytochrome P450s (CYPs) in Families 1–3 Produce Functional Oxylipins from Polyunsaturated Fatty Acids

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