Oxymatrine induces apoptosis in human cervical cancer cells through guanine nucleotide depletion

Su, Baoshan; Chang, Li‐Te; Gao, Qing; Chen, Kunlun; An, Peng; Huang, Chen; Yang, Jun; Li, Zong-Fang

doi:10.1097/cad.0000000000000012

Cited by 35 publications

(35 citation statements)

References 17 publications

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“…Oxymatrine treatment significantly induces apoptosis by increasing Bax protein expression and reducing Bcl-2 in human lung cancer A549 cells [53]. Proteomic analysis has shown that oxymatrine induces apoptosis in HeLa cells by inhibiting inosine monophosphate dehydrogenase type II (IMPDH2), mitochondrial related apoptotic protein [54]. These studies suggest that oxymatrine may be a useful drug candidate for cancer therapy.…”

Section: Traditional Chinese Medicines (Tcms) As Anti-cancer Agentsmentioning

confidence: 99%

“…20( S )-Ginsenoside Rg3 (saponins) chemosensitizes vincristine, doxorubicin, etoposide, and colchicine resistant KBV20 cell lines in a time- and dose-dependent manner [11]. Oxymatrine chemosensitizes cisplatin resistant HeLa/DDP cells by suppressing inosine monophosphate dehydrogenase type II (IMPDH2) levels and inducing apoptosis through the mitochondrial pathway [54]. CKI may also act as a stimulator of drug resistance reversal and chemosensitization in cancer.…”

Section: Chemoresistance In Cancer and Chemosensitization By Naturmentioning

confidence: 99%

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Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action

Aung

Kortschak

et al. 2017

IJMS

270

149

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Many approaches to cancer management are often ineffective due to adverse reactions, drug resistance, or inadequate target specificity of single anti-cancer agents. In contrast, a combinatorial approach with the application of two or more anti-cancer agents at their respective effective dosages can achieve a synergistic effect that boosts cytotoxicity to cancer cells. In cancer, aberrant apoptotic pathways allow cells that should be killed to survive with genetic abnormalities, leading to cancer progression. Mutations in apoptotic mechanism arising during the treatment of cancer through cancer progression can consequently lead to chemoresistance. Natural compound mixtures that are believed to have multiple specific targets with minimal acceptable side-effects are now of interest to many researchers due to their cytotoxic and chemosensitizing activities. Synergistic interactions within a drug mixture enhance the search for potential molecular targets in cancer cells. Nonetheless, biased/flawed scientific evidence from natural products can suggest false positive therapeutic benefits during drug screening. In this review, we have taken these factors into consideration when discussing the evidence for these compounds and their synergistic therapeutic benefits in cancer. While there is limited evidence for clinical efficacy for these mixtures, in vitro data suggest that these preparations merit further investigation, both in vitro and in vivo.

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Section: Traditional Chinese Medicines (Tcms) As Anti-cancer Agentsmentioning

confidence: 99%

Section: Chemoresistance In Cancer and Chemosensitization By Naturmentioning

confidence: 99%

Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action

Aung

Kortschak

et al. 2017

IJMS

270

149

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“…In vivo tumorigenicity was done as previously described [12]. In brief suspensions of tumor cells HT29 (1 Â 10 6 viable cells/mouse) were implanted into the right flank region of BALB/c nude mice.…”

Section: Animal and Tumor Xenograft Assaysmentioning

confidence: 99%

Matrine reduces the proliferation and invasion of colorectal cancer cells via reducing the activity of p38 signaling pathway

Ren¹,

Zhang²,

Ma³

et al. 2014

ABBS

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Matrine has been used in anti-inflammatory and anti-cancer therapies for a long time. However, the anti-metastatic effect and related mechanism(s) in colorectal cancer (CRC) are still unclear. In this study, we investigated whether the administration of matrine could inhibit the proliferation, motility, and invasion of human CRC cells via regulating p38 signaling pathway. Results showed that matrine inhibited migration and invasion of CRC cells in vitro and in vivo. Additionally, after being treated with matrine for 24 h, the expression levels of matrix metalloproteinase-2 (MMP-2) and MMP-9 as well as proteinase activity in CRC cells were reduced in a dose-dependent manner. Moreover, matrine reduced the phosphorylation level of p38 obviously. Combined treatment with p38 inhibitor (SB203580) and matrine resulted in a synergistic reduction of invasion as well as MMP-2/-9 expression in CRC cells. It was also found that matrine inhibited the proliferation and metastasis of CRC tumor in vivo. In conclusion, p38 signaling pathway may involve in matrine's inhibitory effects on migration and invasion of CRC cells by reducing the expression of MMP-2/-9, suggesting that matrine may be a potential therapeutic agent for CRC.

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“…Although the antitumor activities of OMT have been observed in various tumors181920212223243839, there are no reports regarding the effects of OMT on human synovial sarcoma. In this study, we found that OMT inhibited the viability of SW982 cells in a time- and dose-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

HMGB1-mediated autophagy decreases sensitivity to oxymatrine in SW982 human synovial sarcoma cells

Cai

Liu

et al. 2016

Sci Rep

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Oxymatrine (OMT) is a type of alkaloid extracted from a traditional Chinese medicinal herb, Sophora flavescens. Although the antitumor activities of OMT have been observed in various cancers, there are no reports regarding the effects of OMT on human synovial sarcoma. In the present study, we analyzed the antitumor activities of OMT in SW982 human synovial sarcoma cells and determine whether high mobility group box protein 1 (HMGB1)-mediated autophagy was associated with its therapeutic effects. We found that OMT exhibited antitumor activity in SW982 cells and facilitated increases in autophagy. Inhibition of autophagy by 3-MA or ATG7 siRNA increased the level of apoptosis, which indicated that OMT-induced autophagy protected cells from the cytotoxicity of OMT. Administration of OMT to SW982 cells increased the expression of HMGB1. When HMGB1 was inhibited via HMGB1-siRNA, OMT-induced autophagy was decreased, and apoptosis was increased. Furthermore, we found that HMGB1-siRNA significantly increased the expression of p-Akt and p-mTOR. OMT-induced autophagy may be mediated by the Akt/mTOR pathway, and HMGB1 plays a vital role in the regulation of autophagy. Therefore, we believe that combining OMT with an inhibitor of autophagy or HMGB1 may make OMT more effective in the treatment of human synovial sarcoma.

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Oxymatrine induces apoptosis in human cervical cancer cells through guanine nucleotide depletion

Cited by 35 publications

References 17 publications

Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action

Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action

Matrine reduces the proliferation and invasion of colorectal cancer cells via reducing the activity of p38 signaling pathway

HMGB1-mediated autophagy decreases sensitivity to oxymatrine in SW982 human synovial sarcoma cells

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