Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like receptor 4/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury

Dong, Xiao-Qiao; Yu, Wenhua; Hu, Yahong; Zhang, Zu-Yong; Huang, Man

doi:10.1007/s00011-010-0300-7

Cited by 47 publications

(35 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, Zhang et al (11) have demonstrated that OM effectively reduces the serum TNF-α level in rats with L-arginine-induced acute pancreatitis. It has also been shown that OM is able to reduce neuronal cell apoptosis by inhibiting Toll-like receptor 4/nuclear factor κ-B-dependent inflammatory responses in traumatic rat brain injury (14). Collectively, we concluded that OM may protect mice against BLM-induced PF by decreasing the production or activities of these pro-inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 51%

“…(Kushen) that has been approved by the State Food and Drug Administration of China for treating hepatitis B (7,8). Cumulative evidence has suggested that OM possesses multiple biological and pharmacological properties, such as anti-inflammatory (9)(10)(11), antitumor (12,13), anti-apoptotic (14), antifibrotic (15), antioxidant (16), and antiarrhythmic activities (17). Chen et al (18) demonstrated that…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oxymatrine attenuates bleomycin-induced pulmonary fibrosis in mice via the inhibition of inducible nitric oxide synthase expression and the TGF-β/Smad signaling pathway

Liu

Lü

et al. 2012

Int J Mol Med

View full text Add to dashboard Cite

Abstract. Oxymatrine (OM) is an alkaloid extracted from the Chinese herb Sophora flavescens Ait. with a variety of pharmacological activities. The aim of this study was to investigate the preventive effects of OM on bleomycin (BLM)-induced pulmonary fibrosis (PF) and to further explore the underlying mechanisms. C57BL/6 mice were randomly assigned to five groups: the saline sham group; the BLM group, in which mice were endotracheally instilled with BLM (3.0 mg/kg); and the BLM plus OM groups, in which OM was given to mice daily (10, 20 or 40 mg/kg) one day after BLM instillation for 21 days. The bronchoalveolar lavage fluid (BALF) and lung tissues were collected at 15 and 22 days post BLM administration, respectively. Lung tissues were stained with hematoxylin and eosin (H&E) for histological evaluation. Levels of tumor necrosis factor (TNF)-α, interleukin-6 (IL-6) and nitric oxide (NO) in mouse BALF were measured, as well as myeloperoxidase (MPO) activity and malondialdehyde (MDA) content in lung homogenates. The inducible nitric oxide synthase (iNOS) expression in the lung tissues was determined by immunohistochemical staining, quantitative real-time PCR and western blot analysis. Moreover, the expression of transforming growth factor (TGF)-β1, Smad2, Smad3, p-Smad2 and p-Smad3 were also detected. We found that OM improved BLM-induced lung pathological changes, inhibited MPO activity and reduced MDA levels in a dose-dependent manner. OM also dose-dependently inhibited the release of TNF-α and IL-6, and decreased the expression of iNOS in lung tissues and thus prevented NO release in response to BLM challenge. In addition, OM decreased the expression of TGF-β1, p-Smad2 and p-Smad3, which are all important members of the TGF-β/ Smad signaling pathway. Our study provides evidence that OM significantly ameliorated BLM-induced PF in mice via the inhibition of iNOS expression and the TGF-β/Smad pathway.

show abstract

Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Oxymatrine attenuates bleomycin-induced pulmonary fibrosis in mice via the inhibition of inducible nitric oxide synthase expression and the TGF-β/Smad signaling pathway

Liu

Lü

et al. 2012

Int J Mol Med

View full text Add to dashboard Cite

show abstract

“…In the present study, we consistently found that TNF-α plasma level was elevated following AP induction. Various published data have demonstrated that oxymatrine suppresses TNF-α in rats with traumatic brain injury, dextran sulfate sodium-induced colitis, and intestinal I/R injury [19,22,33]. In addition, oxymatrine has been reported to inhibit the quartz-induced secretion of TNF-α by pulmonary alveolar macrophages, thereby antagonizing the damage effect of quartz on the membrane of alveolar macrophages [34].…”

Section: Discussionmentioning

confidence: 99%

“…It has been used to treat chronic hepatitis B patients in China for decades with confirmed safety [14]. Recent evidence has shown that oxymatrine possesses a wide variety of pharmacological effects, including anti-inflammatory, anti-apoptosis, anti-tumor, anti-hepatic fibrosis, and anti-arrhythmic functions [15][16][17][18][19]. In addition, oxymatrine has also been reported to exert a protective effect against end-organ (liver, heart, intestine, and brain) ischemia or ischemia/reperfusion injury [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Oxymatrine Ameliorates l-Arginine-Induced Acute Pancreatitis in Rats

et al. 2011

View full text Add to dashboard Cite

The aim of this study was to determine whether oxymatrine has a protective effect against acute pancreatitis (AP) in a rat model of L-arginine-induced AP. AP was induced by two intraperitoneal injections of L-arginine (250 mg/100 g) at a 1-h interval. Oxymatrine (50 mg/kg) was administered every 6 h after the induction of AP. Oxymatrine significantly reduced the plasma amylase, D-lactic acid and tumor necrosis factor alpha concentration, serum diamine oxidase and lipase activity, and pancreatic myeloperoxidase activity, which were increased in AP rats (P < 0.05). In addition, the pancreatic CD45 expression and the expression of claudin-1, but not zonula occludens-1 (ZO-1) and occludin, in the intestinal tissues were significantly reduced after the induction of AP. However, oxymatrine increased the expression of claudin-1 and CD45, but did not alter the expression of ZO-1 and occludin. In conclusion, our results demonstrated that oxymatrine is potentially capably of protecting against L-arginine-induced AP and attenuating AP-associated intestinal barrier injury by up-regulation of claudin-1.

show abstract

“…[4][5][6] Oxymatrine significantly ameliorates L-arginine-induced acute pancreatitis by the reduction of plasma amylase, D-lactic acid, tumor necrosis factor alpha concentration, serum diamine oxidase, lipase activity, and pancreatic myeloperoxidase activity. 7 The administration of oxymatrine can significantly inhibit inflammatory responses.…”

Section: Anti-inflammatory Propertiesmentioning

confidence: 99%

Oxymatrine and cancer therapy

Zhang

et al. 2015

Eur J Inflamm

View full text Add to dashboard Cite

Oxymatrine is a kind of alkaloid extracted from traditional Chinese herb Sophora flavescens Ait. It has been proved to exert various biological activities such as anti-angiogenesis, proliferation-inhibiting, apoptosis-promoting, analgesicstrengthening, and anti-metastasis. The biological activities are related with inhibition of angiogenesis-associated factors, regulation of related signaling pathway and protein expression, synergistic effects with chemotherapy drug, cell cycle arrest and inhibition of voltage-activated K+ channel. In this review, we summarize the recent investigations of oxymatrine in cancer therapy so as to provide references for further study and clinical therapy.

show abstract

Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like receptor 4/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury

Abstract: OMT may inhibit TLR4/NF-κB-dependent inflammatory responses, and furthermore lessen neuronal cell apoptosis after TBI.

Cited by 47 publications

References 20 publications

Oxymatrine attenuates bleomycin-induced pulmonary fibrosis in mice via the inhibition of inducible nitric oxide synthase expression and the TGF-β/Smad signaling pathway

Oxymatrine attenuates bleomycin-induced pulmonary fibrosis in mice via the inhibition of inducible nitric oxide synthase expression and the TGF-β/Smad signaling pathway

Oxymatrine Ameliorates l-Arginine-Induced Acute Pancreatitis in Rats

Oxymatrine and cancer therapy

Contact Info

Product

Resources

About