Oxyresveratrol Supplementation to C57bl/6 Mice Fed with a High-Fat Diet Ameliorates Obesity-Associated Symptoms

Tan, Handong; Tse, Iris Mei Ying; Li, Edmund Tsze Shing; Wang, Mingfu

doi:10.3390/nu9020147

Cited by 24 publications

(21 citation statements)

References 40 publications

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“…Obesity and overweight are global health problems, which create an environment conducive to the development of chronic noncommunicable diseases. The study of diseases associated with obesity and overweight, and the search for treatments and strategies for disease control have been the subject of multiple investigations [ 2 , 20 , 21 , 22 , 23 ]. In the present study, the effect of ferulic acid on the abdominal adipose tissue, lipid and glucose homeostasis, inflammation biomarkers, and antioxidant capacity in rats fed with a HFD was investigated.…”

Section: Discussionmentioning

confidence: 99%

Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study

et al. 2017

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Obesity is considered to be a low-grade chronic inflammatory process, which is associated with cardiovascular and metabolic diseases. An integral evaluation of the effects of ferulic acid on biomarkers of glucose dysregulation, dyslipidemia, inflammation, and antioxidant potential induced by a high-fat diet (HFD) in rats was carried out. Three groups of male Wistar rats (six per group) consumed a basal diet (BD), which was supplemented with either lard at 310 g/kg (HFD) or lard and ferulic acid at 2 g/kg (HFD + FA), ad libitum for eight weeks. Body weight gain, hyperplasia, and hypertrophy in abdominal fat tissues were higher in the HFD group than in the HFD+FA group. The rats fed a HFD + FA significantly inhibited the increase in plasma lipids and glucose, compared with the HFD group. Biomarkers associated with inflammation were found at higher concentrations in the serum of rats fed a HFD than the HFD + FA group. Plasma antioxidant levels were lower in HFD rats compared to rats fed the HFD + FA. These results suggest that ferulic acid improves the obesogenic status induced by HFD, and we elucidated the integral effects of ferulic acid on a biological system.

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Section: Discussionmentioning

confidence: 99%

Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study

et al. 2017

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“…Oxyresveratrol has been shown to regulate the immune system, exhibit neuroprotective effects, extend lifespan, decrease acute liver injury, and prevent obesity [17,18,20]. These oxyresveratrol-mediated biological effects are believed to be mostly related to the activation of a few signaling pathways similar to the mechanism of resveratrol, a structurally analogous bioactive compound.…”

Section: Resultsmentioning

confidence: 99%

“…Oxyresveratrol (trans-3,5,2’,4’-tetrahydroxystilbene) found in mulberry twigs and fruits (Morus alba L.) has an additional hydroxyl group on the aromatic ring of resveratrol [15]. Oxyresveratrol displays effects in metabolism including lowering cholesterol levels, abrogating hepatic oxidative stress, antihyperlipidemic effects, and anti-obese actions [16,17,18]. However, the molecular mechanism of preventing obesity and its associated metabolic diseases is not understood.…”

Section: Introductionmentioning

confidence: 99%

Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice

Choi

Song

Lee

et al. 2018

IJMS

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The phytochemical oxyresveratrol has been shown to exert diverse biological activities including prevention of obesity. However, the exact reason underlying the anti-obese effects of oxyresveratrol is not fully understood. Here, we investigated the effects and mechanism of oxyresveratrol in adipocytes and high-fat diet (HFD)-fed obese mice. Oxyresveratrol suppressed lipid accumulation and expression of adipocyte markers during the adipocyte differentiation of 3T3-L1 and C3H10T1/2 cells. Administration of oxyresveratrol in HFD-fed obese mice prevented body-weight gains, lowered adipose tissue weights, improved lipid profiles, and increased glucose tolerance. The anti-obese effects were linked to increases in energy expenditure and higher rectal temperatures without affecting food intake, fecal lipid content, and physical activity. The increased energy expenditure by oxyresveratrol was concordant with the induction of thermogenic genes including Ucp1, and the reduction of white adipocyte selective genes in adipose tissue. Furthermore, Foxo3a was identified as an oxyresveratrol-induced gene and it mimicked the effects of oxyresveratrol for induction of thermogenic genes and suppression of white adipocyte selective genes, suggesting the role of Foxo3a in oxyresveratrol-mediated anti-obese effects. Taken together, these data show that oxyresveratrol increases energy expenditure through the induction of thermogenic genes in adipose tissue and further implicates oxyresveratrol as an ingredient and Foxo3a as a molecular target for the development of functional foods in obesity and metabolic diseases.

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“…The phosphorylation of AMPK also enhances fatty acid oxidation by the inactivation of lipogenic enzymes such as ACC [ 35 ]. Dietary bioactive compounds such as sulforaphane [ 11 ], oxyresveratrol [ 36 ] and green tomato extract [ 37 ] prevent high-fat diet-induced obesity and reduce lipid accumulation by stimulating AMPK activity. Consistent with these reports, MFGM administration induced a statistically significant increase in the phosphorylation of AMPK and ACC accompanied by the upregulation of PPARγ, C/EBPα and SREBP-1c protein expression.…”

Section: Discussionmentioning

confidence: 99%

Milk Fat Globule Membrane Attenuates High-Fat Diet-Induced Obesity by Inhibiting Adipogenesis and Increasing Uncoupling Protein 1 Expression in White Adipose Tissue of Mice

Gao

et al. 2018

Nutrients

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Milk fat globule membrane (MFGM), a protein-lipid complex surrounding the fat globules in milk, has many health benefits. The aim of the current study was to investigate whether MFGM could prevent obesity through inhibiting adipogenesis and promoting brown remodeling of white adipose tissue (WAT) in mice fed with high-fat diet. C57BL/6 mice were fed a normal diet (ND), high-fat diet (HFD), HFD plus MFGM at 100 mg/kg BW, 200 mg/kg BW or 400 mg/kg BW for 8 weeks. Results showed that MFGM suppressed body weight gain induced by HFD, reduced white adipose tissue (WAT) mass accompanied with the decrease in adipocyte sizes. MFGM was found to have partially improved serum lipid profiles, as well as to have suppressed HFD-induced adipogenesis as shown by reduced expression of peroxisome proliferators-activator receptor-γ (PPARγ), CCAAT/enhancer-binding protein-α (C/EBPα) and sterol regulatory element-binding protein-1c (SREBP-1c). MFGM also markedly increased the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC), showing activation of AMPK pathway. Moreover, MFGM promoted browning of inguinal WAT by upregulation the protein expression of uncoupling protein 1 (UCP1) in HFD mice. Taken together, these findings provide evidence that MFGM may protect against diet-induced adiposity by suppressing adipogenesis and promoting brown-like transformation in WAT.

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Oxyresveratrol Supplementation to C57bl/6 Mice Fed with a High-Fat Diet Ameliorates Obesity-Associated Symptoms

Cited by 24 publications

References 40 publications

Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study

Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study

Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice

Milk Fat Globule Membrane Attenuates High-Fat Diet-Induced Obesity by Inhibiting Adipogenesis and Increasing Uncoupling Protein 1 Expression in White Adipose Tissue of Mice

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