Oxytalan connective tissue fibers: A review

Fullmer, Harold M.; Sheetz, James H.; Narkates, A. J.

doi:10.1111/j.1600-0714.1974.tb01724.x

Cited by 198 publications

(118 citation statements)

References 43 publications

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“…The hearts were weighed and fixed in formaldehyde 4% buffered pH 7.2-7.4, processed using routine methods, embedded in paraffin, sectioned in 4, 5 or 8µm and stained using: hematoxilin-eosin, Masson's trichrome, picro-sirius red polarization, Weigert's resorcinol fuchsin solution (with and without oxon). The treatment with Weigert's resorcinol fuchsin solution using oxon (10% in water solution during 45 min) is important because the oxon produces oxidation which reveals the oxytalan fibers in violet (9,10). Large amounts of oxytalan fibers suggest increasing stiffness of tissue because these fibers are the less stretching of the elastic fibers.…”

Section: Methodsmentioning

confidence: 99%

Hydralazine reduces myocardial tissue damage in rats submitted to chronic inhibition of systemic nitric oxide synthesis during 4, 14 and 28 days

Xavier-Vidal¹,

Madi²,

Reis³

et al. 2003

J. Bras. Patol. Med. Lab.

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y key words unitermos abstractThe aim of the present work was to develop a qualitative chronopathological study concerning abnormalities in myocardium, due to nitric oxide (NO) blockage. We used 60 Wistar normotensive young male rats from several breeds. Groups of rats were submitted to L-Name (L) via oral administration dissolved in water (750mg/l) during days 4, 14 and 28. Other groups were submitted concomitantly to L-Name and hydralazine hydrocloride (L + H) (120mg/l). On days 4 and 14 (L group) we have found myocardial abnormalities and lesions while in L + H we could not identify abnormalities. Considering L group on day 28, the myocardium presented characteristic fibrosis (reactive and reparative), vascular damage with increasing wall thickness due mainly to proliferation of the arterial smooth muscle cell. Total obliteration of vessels was noted only in this period. We also observed reactive fibrosis between muscle cells of the vascular wall and proliferation of cells in the intimal layer. In L + H (day 28), similar vascular abnormalities described for L group (less frequent and less apparent) were also observed. In L + H we did not identify total vascular obstructions. In L + H, infarct areas were not observed. Control groups did not present any abnormalities. Our results support the idea that, at least in some cases, hypertrophy vascular abnormalities and myocardial lesions in arterial hypertension can occur because of the reduction in organic nitric oxide production. Our results also suggested that these morbid processes can be postponed by the use of hydralazine which, however, does not avoid abnormalities after long-term experimental blockage of NO. O alvo do presente trabalho foi desenvolver um estudo cronopatológico experimental referente a anormalidades miocárdicas com origem no bloqueio sistêmico da síntese do óxido nítrico. Utilizamos 60 ratos wistar machos jovens, oriundos de várias ninhadas. Grupos de ratos foram submetidos ao L-Name (L), por administração via oral, dissolvido em água (750mg/l), durante quatro, 14 e 28 dias. Outros grupos foram submetidos concomitantemente ao L-Name e ao hidrocloreto de hidralazina (L + H) (120mg/l). Aos quatro e 14 dias (grupo L) encontramos anormalidades miocárdicas e lesões. Contudo, nos grupos L + H, aos quatro

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Section: Methodsmentioning

confidence: 99%

Hydralazine reduces myocardial tissue damage in rats submitted to chronic inhibition of systemic nitric oxide synthesis during 4, 14 and 28 days

Xavier-Vidal¹,

Madi²,

Reis³

et al. 2003

J. Bras. Patol. Med. Lab.

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“…Among these matrix proteins, type III collagen and oxytalan connective tissue fibers purportedly formed the most significant components in the periodontal ligament and odontogenic ectomesenchyme [11][12][13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

Localization of Oxytalan Fiber, type III Collagen and BMP Family in Conventional and Desmoplastic Ameloblastoma

Inoue

Nagatsuka²,

Tamamura

et al. 2008

J. Hard Tissue Biology.

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Abstract:The histologic hallmark distinguishing desmoplastic ameloblastoma (DA) from conventional ameloblastoma (CA) is its pronounced stromal desmoplasia, and this formed the basis of this investigation. To elucidate the stromal characteristics, localization patterns of oxytalan fibers, type III collagen and BMP family in DA (n=8) was compared with CA (n=24), and periodontal ligament (PL) (n= 8). Oxytalan fibers formed apico-occlusal bundles in PL, thick radial bundles around tumor nests in DA, and as scanty fibers in CA. Type III collagen was identified in PL, strongly expressed in DA stroma, but weakly in CA. BMP-2, -3, -4 and -7 expression patterns in tumor epithelium and stroma were more pronounced in DA (including sites of bone formation), than CA. No immunoreactivity for BMP-5 and -6 were detected. Current findings suggest that the stroma in DA is neoplastic and derived from odontogenic ectomesenchyme, and recommends its reclassification as an odontogenic epithelial-ectomesenchymal neoplasm.

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“…A number of these elements have been reported to be rich in microfibrils -e.g., the ciliary zonule of the eye is composed predominantly of 12 nm microfibrils (9; 23) as are the oxytalan fibres of periodontal ligament (8) and skin (7). Similar microfibrils have been observed in the mesangium of the renal glomerulus (24).…”

Section: Discussionmentioning

confidence: 99%

“…5,6). In addition, morphologically similar microfibrils in this size range have been demonstrated in a number of tissues including skin (7), periodontal ligament (8) and the ocular ciliary zonule (9). In these latter locations their histochemical staining properties have led to their being called 'oxytalan' fibres (8).…”

Section: Introductionmentioning

confidence: 99%

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The immunohistochemical localisation of microfibril‐associated glycoprotein (MAGP) in elastic and non‐elastic tissues

Gibson

Cleary

1987

Immunol Cell Biol

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Summarj.We have previously identified the major antigen of elastin-associated microfibrils as a 31kD glycoprotein which we named microfibril-associated glycoprotein or MAGP. Affinity-purified antibodies to MAGP were shown to localise specifically to elastin-associated microfibrils in sections of bovine foetal nuchat ligament (20). In the present paper we compare the localisaiion of anti-MAGP antibodies and antitropoelaslin antibodies in a range of bovine elastic and non-elastic tissues. The results show that anti-MAGP antibodies invariably localised to imtnuno-reactive elastic fibres, wherever they occurred. Extensive additional localisation was observed in a number of tissues. This extra distribution of anti-MAGP antibodies was found to correspond to those structures exhibiting the oxytalan histochemical staining reaction in tissues such as skin, periodontal tigament and ocular zorute. Since these oxytalan fibres have been shown lo consist of 12 nm microfibrils which are morphologically similar to those of elastic fibres (and unpubtished data from this laboratory confirm this conclusion), the results suggest that MAGP is a component of 12 nm microfibrils in both elastic and non-e!astic tissues. Anti-tropoetastin antibodies did not localise to these oxytalan fibres, suggesting that tropoetastin is not a component of 12 nm tiiicrofibrils. MAGP was also detected in extracellular matrix regions of tissues such as skeletal muscle. Achilles tendon and spleen, suggesting that 12 nm microfibrils, containing one or more macromolecular constituents in common, make up an important structural system within the extracellular matrix in a wide range of elastic and non-elastic tissues.

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Oxytalan connective tissue fibers: A review

Cited by 198 publications

References 43 publications

Hydralazine reduces myocardial tissue damage in rats submitted to chronic inhibition of systemic nitric oxide synthesis during 4, 14 and 28 days

Hydralazine reduces myocardial tissue damage in rats submitted to chronic inhibition of systemic nitric oxide synthesis during 4, 14 and 28 days

Localization of Oxytalan Fiber, type III Collagen and BMP Family in Conventional and Desmoplastic Ameloblastoma

The immunohistochemical localisation of microfibril‐associated glycoprotein (MAGP) in elastic and non‐elastic tissues

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