Oxytocin ameliorates oxidative colonic inflammation by a neutrophil-dependent mechanism

İşeri, Sevgin Özlem; Şener, Göksel; Sağlam, Beyhan; Gedik, Nursal; Ercan, Feríha; Yeğen, Berrak Ç.

doi:10.1016/j.peptides.2004.10.005

Cited by 120 publications

(84 citation statements)

References 52 publications

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“…In recent years, more evidence has indicated that OT may play a role in regulation of the gastrointestinal (GI) functions such as motility, sensation (13,18), and immune response to inflammation (4,10). Exogenous OT influences the GI motility, although the reports are diverse because of the differences of species, methods, and area of the gut (18,24).…”

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confidence: 99%

Estradiol upregulates the expression of oxytocin receptor in colon in rats

Feng

Qin²,

Wang³

et al. 2009

American Journal of Physiology-Endocrinology and Metabolism

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The study was designed to investigate the effect of estradiol on the excitatory effect of oxytocin (OT) on colon motility. Female Wistar rats were used, and some of them were ovariectomized (OVX) and treated with vehicle or estradiol (E2). A plastic balloon made of condom was inserted into colon to monitor the change of colonic pressure in vivo. Longitudinal muscle strips of distal colon were prepared to monitor the spontaneous contraction of colon in vitro. Expression of OT receptor (OTR) was investigated by Western blot analysis. Expression of OTR mRNA was detected by RT-PCR. Immunohistochemistry was used to locate OTR. In OVX rats, pretreatment of E2 (4 -100 g/kg sc) dose-dependently increased the excitatory effect of OT on colon motility both in vivo and in vitro and increased the expression of OTR and OTR mRNA in colon. Systemic administration of OT excited the colon motility in vivo in rats at perioda of proestrus and estrus but did not influence it at diestrus period, when the concentration of plasma E2 was lowest in the estrous cycle. Pretreatment of atosiban, the specific OTR antagonist, and TTX, the blocker of voltage-dependent sodium channel on nerve fiber, attenuated the excitatory effect of OT on colon motility. OTR was located in myenteric plexus of colon. These results suggested that E2 increased the excitatory effect of OT on colon motility by upregulating the expression of OTR in myenteric plexus.colon; motility OXYTOCIN (OT) has been traditionally regarded as a hormone that is involved in parturition and milk ejection. In recent years, more evidence has indicated that OT may play a role in regulation of the gastrointestinal (GI) functions such as motility, sensation (13, 18), and immune response to inflammation (4, 10). Exogenous OT influences the GI motility, although the reports are diverse because of the differences of species, methods, and area of the gut (18, 24). It has been suggested that the effect of OT on GI motility might be physiological. OT is released in response to a fatty meal in women (16). Systemic administration of atosiban, the antagonist of OT receptor (OTR), inhibited the spontaneous contraction of gallbladder in rabbits (12) and gastric emptying in humans (16). It has been well established that mRNA for OT and its receptor can be found throughout the human GI tract (15), but the cell types that express OTR were undetectable in human gut by indirect immunofluorescence (19).In women, colonic dysmotility is very common, and bowel function changes during the reproductive cycle. Although the fluctuation of steroid hormones, especially estradiol (E 2 ) and progesterone, were believed to be the major reason, the mechanism has not been clearly illustrated. Steroid hormones regulate the activity of OTR via both genomic and nongenomic pathways (26). E 2 induced the mRNA expression of the OTR and increased the OTR density on the membranes of the uterine smooth muscle and central nervous system (8, 21). The recent study of our group also indicated that the pretreatment of E 2 increas...

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confidence: 99%

Estradiol upregulates the expression of oxytocin receptor in colon in rats

Feng

Qin²,

Wang³

et al. 2009

American Journal of Physiology-Endocrinology and Metabolism

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“…However, only the change of SOD activity was significant in two groups. In different studies, AA-induced colitis was increased the MPO activity [26,27,[32][33][34] and MDA levels [26,27,[32][33][34] and could decrease SOD activity [26,27,32,34]. The levels of colonic MPO and MDA, indicating infiltration of neutrophils, are decreased by lithium, ginger extract, and sulfasalazine in AA-induced colitis in rats [32].…”

Section: Discussionmentioning

confidence: 98%

Effect of colchicine on experimental acetic acid induced colitis

Yıldırım¹,

Tuncer²,

Şahin³

et al. 2014

Turk J Bioch

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“…OT has been demonstrated to cause the release of nitric oxide (NO), which inhibits neutrophil infiltration and adhesion formation [22] . In the case of sepsis due to cecal ligation and puncture, massive inflammatory mediators such as NO are produced and it has been reported that via the central NO-cGMP pathway the arginine vasopressin (AVP) and OT gene expressions are increased [23] .…”

Section: Discussionmentioning

confidence: 99%

Uterotonik Bir Ajandan Fazlası: Oksitosin Postoperatif Adezyonları Önlüyor

Işık¹,

Şahbaz²,

Aynıoğlu³

et al. 2016

Kafkas Univ Vet Fak Derg

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Prevention of postoperative adhesions (PPA) has become an important issue. The aim is to investigate the effect of Oxytocin (OT) on PPAs. A total of thirty female Wistar-albino rats were randomly divided into three groups (10 rats/group). The cecal peritone of Group I rats (controls) were scraped, to trigger adhesion formation, and no treatment were given. After cecal scrubbing, 1 mL saline solution was applied to each rat in Group II (i.p. saline treated group) and 80 IU/kg of OT (Pituisan®, Ege Vet, Turkey) to Group III (i.p. OT treated group) intraperitoneally. All animals were sacrificed 10 days after surgery and adhesions graded in terms of severity and histopathologic characteristics. The median scores for the extent, severity, and degree of adhesions in Group I and Group II were statistically significant and considerably higher than those scores for Group III (P<0.001). The inflammation, neovascularization, and fibrosis scores for Group III were statistically significant and considerably lower than those scores for Groups I and II (P<0.001, P<0.001 and P=0.002 respectively). OT, significantly prevented adhesion formation improving wound healing possibly by suppressing adhesion formation with anti-inflammatory and antioxidant properties. OT may be useful in the prevention of PPA in humans.

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Oxytocin ameliorates oxidative colonic inflammation by a neutrophil-dependent mechanism

Cited by 120 publications

References 52 publications

Estradiol upregulates the expression of oxytocin receptor in colon in rats

Estradiol upregulates the expression of oxytocin receptor in colon in rats

Effect of colchicine on experimental acetic acid induced colitis

Uterotonik Bir Ajandan Fazlası: Oksitosin Postoperatif Adezyonları Önlüyor

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