Oxytocin and autistic disorder: alterations in peptide forms

Green, LeeAnne; Fein, Deborah; Modahl, Charlotte; Feinstein, Carl; Waterhouse, Lynn; Morris, Mariana

doi:10.1016/s0006-3223(01)01139-8

Cited by 382 publications

(256 citation statements)

References 21 publications

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“…For males, vasopressin has been shown to evoke partner preference and aggression after mating (Winslow et al, 1993). Recently, it has been found that children with autism show alterations in the endocrine oxytocin system, suggesting that deficits in oxytocin peptide processing may be important in the development of autism (Green et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…In normal children, Modahl et al found that the oxytocin plasma level was related to the mastery of social conventions and socialization items, while the opposite was found to be true in children with autism. Green et al (2001) reported deficits in oxytocin-processing peptides in autistic children. Of interest, genetic syndromes such as Prader-Willi (15q 13-14) have oxytocin abnormalities and a polypeptide that shares this chromosomal site influences pro-hormone convertace (PC2), whose gene (20p 11-1-11-2) is proximal to the oxytocin gene, and chromosomal abnormalities at this site have been identified in autistic individuals (Cook, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders

Hollander

Novotny

Hanratty

et al. 2003

Neuropsychopharmacol

624

403

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Autism is a neurodevelopmental disorder characterized by dysfunction in three core behavioral domains: repetitive behaviors, social deficits, and language abnormalities. There is evidence that abnormalities exist in peptide systems, particularly the oxytocin system, in autism spectrum patients. Furthermore, oxytocin and the closely related peptide vasopressin are known to play a role in social and repetitive behaviors. This study examined the impact of oxytocin on repetitive behaviors in 15 adults with autism or Asperger's disorder via randomized double-blind oxytocin and placebo challenges. The primary outcome measure was an instrument rating six repetitive behaviors: need to know, repeating, ordering, need to tell/ask, self-injury, and touching. Patients with autism spectrum disorders showed a significant reduction in repetitive behaviors following oxytocin infusion in comparison to placebo infusion. Repetitive behavior in autism spectrum disorders may be related to abnormalities in the oxytocin system, and may be partially ameliorated by synthetic oxytocin infusion.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders

Hollander

Novotny

Hanratty

et al. 2003

Neuropsychopharmacol

624

403

View full text Add to dashboard Cite

show abstract

“…There are also specific hypotheses (supported by varying degrees of evidence) linking oxytocin and ASD, specifically, that autistic children tend to be characterized by lower levels of plasma OT (13,14), and that infusion of OT is related to the reduction of repetitive behaviors in patients with ASD (15). For example, it has been hypothesized that administration of OT during labor can generate excess OT in the fetal brain.…”

mentioning

confidence: 99%

Genes Controlling Affiliative Behavior as Candidate Genes for Autism

Yrigollen¹,

Han²,

Kochetkova³

et al. 2008

Biological Psychiatry

164

124

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“…Other hypotheses implicate overactive brain opioid systems and changes in oxytocin neurotransmission. Green et al also have suggested that children with autistic disorder show alterations in the endocrine oxytocin system [75]. A frequently cited finding is the dysfunction of cerebellar-cortical serotonergic pathways [76].…”

Section: Neurobiological Factorsmentioning

confidence: 99%

Autism-A Multifaceted Diffuse Pathology

Brejlova¹,

Domkarova²,

Stefano³

2015

J Psychiatry

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Journal of Psychiatry AbstractThe causes of pervasive developmental disorders have yet to be resolved. Needless to say, the etiology is complex as are the individual factors, especially in regard to autism. Certain findings may be integrated into early coherent models, but the heterogeneity of findings remains a central feature of autism. The present review examines contemporary areas of research and a few prominent theories specifically dealing with autism. The areas under scrutiny are divided into common academic compartments, such as biological, environmental. Autism represents a very timely topic due to its rising incidence in the population as well as changes in previous concepts occurring at this time. Besides the neurological, biological and epidemiological factors contributing and possibly initiating this disorder we discuss the possible involvement of endogenous morphine, especially in regard to depression and limbic functions. Lastly, we advance the theory that dysfunctional mitochondria appear to be involved in autism as well, explaining the widespread occurrence of its characteristics within the construct of susceptibility to stress and trauma. Thus, the diffuse manifestations of Pervasive Developmental Disorder occur potentially by altering energy processes.

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Oxytocin and autistic disorder: alterations in peptide forms

Cited by 382 publications

References 21 publications

Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders

Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders

Genes Controlling Affiliative Behavior as Candidate Genes for Autism

Autism-A Multifaceted Diffuse Pathology

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