Oxytocin and bone status in men: analysis of the MINOS cohort

Abstract

In men, serum OT levels are not associated with BMD, bone turnover rate, or prevalent fractures. The weak negative relationship with fracture risk requires further studies.

Positive Association of High Leptin Level and Abdominal Aortic Calcification in Men ― The Prospective MINOS Study ―

“…Serum aliquots were stored at −80°C without thawing until the assay in 2011. 24 In order to limit the interassay variability, measurements were performed using kits from a single series ( Table 1).…”

“…The MINOS study is a prospective single-center cohort study of osteoporosis in men aged 50-85 years. 24 This collaborative project involves the Institut National de la Santé et de la Recherche Médicale and Société de Secours Minière de Bourgogne, a health insurance service for families of mineworkers living in Montceau-les-Mines. The study was approved by the Ethical Board and performed as total weekly intake of wine, beer, and spirits, expressed in g/week.…”

“…Lifestyle and health status were assessed using intervieweradministered questionnaires at baseline. 24 If possible, all information was checked. Smoking was categorized as current, former, and never.…”

“…26 Testosterone, 17β-estradiol, 25-hydroxycholecalciferol (25OHD) parathyroid hormone (PTH) and osteocalcin were measured as described previously. 24,25 Glomerular filtration rate (GFR) was calculated using the CKD-EPI equation.…”

Newly Discovered Physiological Effects of Oxytocin

“…These same AA had impairments in the microarchitecture of both cortical and trabecular bone. However, low OT levels in older men are not associated with an increased risk of bone loss [42].…”