Oxytocin and cabergoline alleviate ovarian hyperstimulation syndrome (OHSS) by suppressing vascular endothelial growth factor (VEGF) in an experimental model

Hortu, İsmet; Karadadaş, Elif; Özçeltik, Gökay; Tavmergen, Erol; Göker, Ege Nazan Tavmergen; Yiğittürk, Gürkan; Erbaş, Oytun

doi:10.1007/s00404-020-05855-1

Cited by 18 publications

(15 citation statements)

References 32 publications

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“…[2020], who found that cabergoline can effectively lower the occurrence of OHSS in ovulation-inducing therapy [34]. Corbett and his colleagues [2014] Doctors at an infertility clinic reported a substantial decrease in the occurrence of hyperstimulation syndrome after using a dosage of 0.5 mg cabergoline every 3 days for a total of 4 doses from the start date of the Machu egg release medication.…”

Section: Results and Dissectionmentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

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Background: Polycystic ovarian syndrome (PCO) is among the most common reasons for infertility in women of reproductive age. Objective: to examine two pharmaceutical regimens for infertile women with polycystic ovarian syndrome. Method: In this randomized clinical trial, 60 infertile women with PCO were randomly assigned into two arms, each having 30 subjects. The first arm received Clomiphene citrate (CC) followed by letrozole. The second arm received letrozole followed by cabergoline. Following the procedures, outcomes of biochemical pregnancy and incidence of the complications were recorded along with other baseline characteristics and laboratory data. Results: Concerning age, weight, height, and BMI, both arms were matched. In terms of follicle quantity and size, as well as endometrial thickness, with no statistical differences among the study arms, although the cabergolineletrozole regimen demonstrated a considerably higher success rate in the treatment of infertility. The endometrial examination revealed three-layered and transparent endometrium in both arms, although it was statistically more common in the letrozole-cabergoline arm (P = 0.001). The successful pregnancy was achieved in 9 cases (30%) in the first arm and 7 (23.3%) in the second arm (P=0.54), with no significant difference in adverse maternal events. Conclusion:The letrozole-cabergoline regimen appears to be more successful in inducing ovulation in infertile women with PCOs. Other trials should be conducted over longer periods of time and at varied dosages to provide a more exact evaluation of its effect.

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Section: Results and Dissectionmentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

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“…Several mediators such as prostaglandins, the renin angiotensin aldosterone system, histamine, and inflammatory mediators have been implicated but among those VEGF plays the most important role in its pathogenesis by increasing vascular permeability [Ku-mar et al, 2011]. Exogenous and/or endogenous hCGdependent increase in VEGF is known as the main regulator of many pathophysiological processes in OHSS [Hortu et al, 2021]. As a result, targeting the VEGF system to prevent OHSS became the basis for many researches [Kasum et al, 2017;Petrenko et al, 2019].…”

Section: Discussionmentioning

confidence: 99%

A Histopathological Evaluation of Ovarian Hyperstimulation Syndrome on Reproductive and Vital Organs and the Role of the VEGF-PKA Pathway in a Mouse Model

Karabulut

Korkmaz

Altun

et al. 2021

Cells Tissues Organs

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Ovarian hyperstimulation syndrome (OHSS) is one of the most common and iatrogenic complications of in vitro fertilization therapy, which is an exaggerated response to excess hormones resulting in the development of a large number of maturing follicles. Although the complications of and reasons for the condition are well known, the overall histopathological effects on systemic organs and the extent of the damage have not been fully elucidated. Besides, the mechanism that underlies the situation is not very well known. The aim of the present work was to analyse the histopathological effects of OHSS on reproductive (uterus and ovary) and vital organs (liver and kidney) and the possible role of the VEGF-PKA pathway in triggering the condition. Balb/c mice were used to establish an OHSS model. The OHSS group were injected with overdose PMSG while the normal responder group were injected with an optimal dose. Histopathological evaluation was utilised in the liver, kidney, ovary, and uterus stained with hematoxylin and eosin, Masson’s trichrome, and periodic acid-Schiff stain. The expression profiles of VEGF (vascular endothelial growth factor), PKA (protein kinase A), and p-PKA (an activated form of PKA) were detected with immunohistochemistry and Western blotting. OHSS was demonstrated to have a negative histopathological effect on all of the organs analysed. These effects were associated with an overall increase in the expression levels of VEGF, PKA, and p-PKA. OHSS has a serious histopathological negative effect on the systemic and reproductive organs and is proven to affect overall health, and thus should be considered a dangerous complication during ART techniques. The activation of the VEGF-PKA pathway, which is indicated by the expression levels of VEGF, PKA, and p-PKA, is demonstrated to accompany this complication, which should be further elucidated to understand the mechanisms underlying the condition.

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“…Ovarian hyperstimulation syndrome (OHSS) is the most serious iatrogenic complication of controlled ovarian hyperstimulation (COH) with exogenous gonadotropins in assisted reproductive techniques (ARTs) [ 1 , 2 ]. In OHSS, ovarian enlargement occurs, and protein-rich fluid extravasation is induced from the vascular space toward the peritoneal cavity.…”

Section: Introductionmentioning

confidence: 99%

“…/kg) dissolved in 1 mL of DMSO via oral gavage two hours before PMSG injection for four consecutive days and also two hours before hCG administration on the final day A standard protocol was applied for the OHSS model[1].…”

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confidence: 99%

Treatment of Ovarian Hyperstimulation Syndrome in a Mouse Model by Cannabidiol, an Angiogenesis Pathway Inhibitor

Tahermanesh

Hakimpour

Govahi

et al. 2022

BioMed Research International

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Studies suggest that ovarian hyperstimulation syndrome (OHSS) can be treated by reducing the level of vascular endothelial growth factor (VEGF). However, due to the side effects of commercially available VEGF-reducing drugs, they can be ruled out as a suitable treatment for OHSS; therefore, researchers are looking for new medications to treat OHSS. This study is aimed at investigating the effects of cannabidiol (CBD) in an OHSS model and to evaluate its efficacy in modulating the angiogenesis pathway and VEGF gene expression. For this purpose, 32 female mice were randomly divided into four groups (eight mice per group): control group, group 2 with OHSS induction, group 3 receiving 32 nmol of dimethyl sulfoxide after OHSS induction, and group 4 receiving 30 mg/kg of CBD after OHSS induction. The animals’ body weight, ovarian weight, vascular permeability (VP), and ovarian follicle count were measured, and the levels of VEGF gene and protein expression in the peritoneal fluid were assessed. Based on the results, CBD decreased the body and ovarian weights, VP, and corpus luteum number compared to the OHSS group ( p < 0.05 ). The peritoneal VEGF gene and protein expression levels reduced in the CBD group compared to the OHSS group ( p < 0.05 ). Also, CBD caused OHSS alleviation by suppressing VEGF expression and VP. Overall, CBD downregulated VEGF gene expression and improved VP in OHSS.

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Oxytocin and cabergoline alleviate ovarian hyperstimulation syndrome (OHSS) by suppressing vascular endothelial growth factor (VEGF) in an experimental model

Cited by 18 publications

References 32 publications

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A Histopathological Evaluation of Ovarian Hyperstimulation Syndrome on Reproductive and Vital Organs and the Role of the VEGF-PKA Pathway in a Mouse Model

Treatment of Ovarian Hyperstimulation Syndrome in a Mouse Model by Cannabidiol, an Angiogenesis Pathway Inhibitor

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