Oxytocin and cancer: An emerging link

Lerman, Ben; Harricharran, Trisheena; Ogunwobi, Olorunseun O.

doi:10.5306/wjco.v9.i5.74

Cited by 33 publications

(31 citation statements)

References 100 publications

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“…The initial research into the uterotonic effect of OT in the female has been extended to research into OT's contractile potential throughout both the female and male reproductive tracts. It is only in recent years that the focus has shifted to further OT-effects such as (malignant) proliferation (1,2), metabolism (3), central nervous system, and social behavior changes (4) resulting from additional OT-signaling pathways. Receptor binding, and its colocalization with other receptors, also appear to be important in determining oxytocin's role in different processes.…”

Section: Introductionmentioning

confidence: 99%

Oxytocin in the Male Reproductive Tract; The Therapeutic Potential of Oxytocin-Agonists and-Antagonists

Stadler

Whittaker²,

Exintaris³

et al. 2020

Front. Endocrinol.

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In this review, the role of oxytocin and oxytocin-like agents (acting via the oxytocin receptor and belonging to the oxytocin-family) in the male reproductive tract is considered. Previous research (dating back over 60 years) is revised and connected with recently found aspects of the role oxytocin plays in male reproductive health. The local expression of oxytocin and its receptor in the male reproductive tract of different species is summarized. Colocalization and possible crosstalk to other agents and receptors and their resulting effects are discussed. The role of the newly reported oxytocin focused signaling pathways in the male reproductive tract, other than mediating contractility, is critically examined. The structure and effect of the most promising oxytocin-agonists and-antagonists are reviewed for their potential in treating male disorders with origins in the male reproductive tract such as prostate diseases and ejaculatory disorders.

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Section: Introductionmentioning

confidence: 99%

Oxytocin in the Male Reproductive Tract; The Therapeutic Potential of Oxytocin-Agonists and-Antagonists

Stadler

Whittaker²,

Exintaris³

et al. 2020

Front. Endocrinol.

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“…Activation of cyclin-dependent kinase inhibitor (p21) and/or of Protein Kinase A, due to OXTR or vasopressin receptor coupling with Gαi and Gαs, respectively, may exert anti-proliferative actions. However, predominant OXTR coupling with Gαq, leading to stimulation of the ERK pathway, may override the cell growth-inhibitory pathway (Lerman et al 2018). Further, the membrane localization of OXTR may also play a role.…”

Section: Discussionmentioning

confidence: 99%

Cell proliferation and anti-oxidant effects of oxytocin and oxytocin receptors: role of extracellular signal-regulating kinase in astrocyte-like cells

Alanazi

Havránek

Bakoš

et al. 2020

Endocrine Regulations

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Objectives. Oxytocin (OXT) participates in various physiological functions ranging from reproduction to social and non-social behaviors. Recent studies indicate that OXT affects cell growth and metabolism. Here we characterized the growth stimulating and antioxidant actions of OXT and of OXT receptors (OXTR) in a glial cell-line (U-87MG).Methods. We developed an OXTR-knockdown cell-line (U-87MG KD) to establish the receptor specificity of OXT’s actions, and the impact of lacking OXTR on growth and survival in glial cells. The role Extracellular-Signal Regulated Kinases (ERK1/2) on glial cell protection against consequences of oxidative stress, and cell proliferation was investigated.Results. In U-87MG cells, OXT stimulated cell proliferation and increased ERK1/2 phosphorylation. The specific ERK1/2 inhibitor, PD098059, produced marked inhibition of cell proliferation, and antagonized the stimulating effect of OXT on ERK1/2 phosphorylation and on cell proliferation. Slower growth rates and lower levels of phosphorylated ERK1/2 were observed in OXTR-knockdown cells and in U-87MG cells treated with an OXTR antagonist (L-371,257). In addition to increasing cell proliferation, OXT significantly blunted the rise in reactive oxygen species induced by H2O2, and antagonized the reductions in cell viability induced by H2O2 and camptothecin. The cell protective and antioxidant actions of OXT in U-87MG cells were not observed in the OXTR-knockdown cells.Conclusion. OXT stimulates the growth of astrocyte-like cells acting on OXTR via ERK1/2 phosphorylation. The protection against apoptosis and the antioxidant capacity of OXT may contribute to the observed increase in cell proliferation. Oxytocin and OXTR appear to be fundamental for cell growth and viability of glial cells.

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“…Future research is needed to further elucidate the involvement of oxytocin in cancer, and whether it could be a clinical cancer biomarker or therapeutic target. 52…”

Section: Oxytocin and Cancermentioning

confidence: 99%

The multifarious oxytocin: a review

Kapur

2019

Int J Res Med Sci

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Oxytocin over centuries has always been regarded as the drug of paramount importance during childbirth. Oxytocin, a peptide hormone facilitates parturition and breastfeeding. These nine amino acid peptides have presently been found to be associated with a wide variety of pathophysiological functions associated with social behaviours. It has been recently recognised as an important modulator of human social behaviour. Its correlation as a common factor important in various neuropsychiatric disorders such as schizophrenia, personality disorders and autism, mood and anxiety disorders has been highlighted. Anticipatory role of oxytocin in osteoporosis, diabetes and cancer has been coaxing the researchers for developing new therapeutic modalities. Over a course of past 100 years, oxytocin has come a long way from being an insipid agent used as an aid in labour and delivery to the drug of neuropsychiatric conditions. This review article summarises the varied functions of oxytocin, its apt dosing when used therapeutically and reinforcement of development of new lines of treatment involving the use of oxytocin and antagonists for multiple human disorders.

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Oxytocin and cancer: An emerging link

Cited by 33 publications

References 100 publications

Oxytocin in the Male Reproductive Tract; The Therapeutic Potential of Oxytocin-Agonists and-Antagonists

Oxytocin in the Male Reproductive Tract; The Therapeutic Potential of Oxytocin-Agonists and-Antagonists

Cell proliferation and anti-oxidant effects of oxytocin and oxytocin receptors: role of extracellular signal-regulating kinase in astrocyte-like cells

The multifarious oxytocin: a review

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