Oxytocin and cardiometabolic interoception: Knowing oneself affects ingestive and social behaviors

Smith, Justin A.; Eikenberry, Sophia A.; Scott, Karen A.; Harrison, Caitlin Baumer; Lartigue, Guillaume de; Kloet, Annette D. de; Krause, Eric G.

doi:10.1016/j.appet.2022.106054

Cited by 2 publications

(2 citation statements)

References 199 publications

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“…The central and peripheral actions of vasopressin in blood-pressure regulation are well documented [ 172 , 257 ]. Oxytocin has various actions, including inhibition of sodium appetite, and has been implicated in blood-pressure regulation and these actions are reviewed in detail in [ 258 ]. Another key mechanism of the PVN in regulating cardiovascular homeostasis to stressors is the HPA axis.…”

Section: Neural and Hormonal Control Of Blood-pressurementioning

confidence: 99%

Sodium Intake and Disease: Another Relationship to Consider

et al. 2023

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Sodium (Na+) is crucial for numerous homeostatic processes in the body and, consequentially, its levels are tightly regulated by multiple organ systems. Sodium is acquired from the diet, commonly in the form of NaCl (table salt), and substances that contain sodium taste salty and are innately palatable at concentrations that are advantageous to physiological homeostasis. The importance of sodium homeostasis is reflected by sodium appetite, an “all-hands-on-deck” response involving the brain, multiple peripheral organ systems, and endocrine factors, to increase sodium intake and replenish sodium levels in times of depletion. Visceral sensory information and endocrine signals are integrated by the brain to regulate sodium intake. Dysregulation of the systems involved can lead to sodium overconsumption, which numerous studies have considered causal for the development of diseases, such as hypertension. The purpose here is to consider the inverse—how disease impacts sodium intake, with a focus on stress-related and cardiometabolic diseases. Our proposition is that such diseases contribute to an increase in sodium intake, potentially eliciting a vicious cycle toward disease exacerbation. First, we describe the mechanism(s) that regulate each of these processes independently. Then, we highlight the points of overlap and integration of these processes. We propose that the analogous neural circuitry involved in regulating sodium intake and blood pressure, at least in part, underlies the reciprocal relationship between neural control of these functions. Finally, we conclude with a discussion on how stress-related and cardiometabolic diseases influence these circuitries to alter the consumption of sodium.

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Section: Neural and Hormonal Control Of Blood-pressurementioning

confidence: 99%

Sodium Intake and Disease: Another Relationship to Consider

et al. 2023

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“…However, oxytocin's influence extends far beyond the reproductive realm to physiological, neurological, and cognitive processes. In recent years, researchers have discovered that oxytocin acts as a versatile neuromodulator, exerting effects on various physiological and cognitive processes [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

The Love Hormone and Seizure Control: A Review of Oxytocin’s Impact on Epilepsy Management

Makhado,

Gertie Makhado

2024

Oxytocin and Social Function

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Epilepsy is a neurological disorder characterised by recurrent seizures, which can significantly impact patient’s quality of life. While current management strategies for epilepsy, such as antiepileptic drugs and surgery, are effective for many patients, there is a need for novel therapies that can provide better seizure control and improve patients’ outcomes. Oxytocin, a neuropeptide known for its role in social bonding and trust, has emerged as a promising therapy for epilepsy. Preclinical studies have shown that oxytocin can reduce seizure activity and improve seizure outcomes in animal models of epilepsy. In contrast, clinical studies have suggested that oxytocin may reduce seizure frequency and severity in some epilepsy patients. This chapter reviews the current knowledge of oxytocin and epilepsy, including the potential mechanisms of oxytocin’s antiepileptic effects, the limitations and challenges of clinical studies, and future research directions and implications. The chapter also discusses the broader impact of oxytocin research on understanding social behaviour and neurological disorders. Overall, the chapter highlights the potential of oxytocin as a novel therapy for epilepsy management and underscores the need for further research.

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Oxytocin and cardiometabolic interoception: Knowing oneself affects ingestive and social behaviors

Cited by 2 publications

References 199 publications

Sodium Intake and Disease: Another Relationship to Consider

Sodium Intake and Disease: Another Relationship to Consider

The Love Hormone and Seizure Control: A Review of Oxytocin’s Impact on Epilepsy Management

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