1987
DOI: 10.1159/000124794
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Oxytocin and Vasopressin Immunoreactivity in Hypothalamic and Extrahypothalamic Sites in Late Pregnant and Postpartum Rats

Abstract: This study examines immunoreactive levels of oxytocin (OT) and arginine-vasopressin (AVP) from acid extracts of the paraventricular nucleus (PVN), supraoptic nucleus (SON), anterior commissural nucleus (ACN) and the suprachiasmatic nucleus (SCN) as well as selected extrahypothalamic sites in pregnant or postpartum (PP) rats. Animals are sacrificed between 08.30 and 10.30 h 16 or 22 days after sperm is detected in their vaginal smears or on the morning after parturition. Peptide levels of pregnant or PP animals… Show more

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Cited by 140 publications
(73 citation statements)
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“…From this study we conclude that at least part of the sensitivity of POA cells to estrogen is mediated via effects on OXT mRNA levels. Our finding of a difference in response to estrogen in the POA compared with the AH is consistent with our previous finding that the LSN and PVN showed differential patterns of OXT immunoreactivity peripartum (4). Cells in the PeV also demonstrated this rostrocaudal dichotomy in response to estrogen.…”
Section: Discussionsupporting
confidence: 92%
“…From this study we conclude that at least part of the sensitivity of POA cells to estrogen is mediated via effects on OXT mRNA levels. Our finding of a difference in response to estrogen in the POA compared with the AH is consistent with our previous finding that the LSN and PVN showed differential patterns of OXT immunoreactivity peripartum (4). Cells in the PeV also demonstrated this rostrocaudal dichotomy in response to estrogen.…”
Section: Discussionsupporting
confidence: 92%
“…In fact, the brain AVP system is activated around birth; AVP mRNA expression (16,17,19) and immunoreactivity (20) within the hypothalamus is elevated in lactation, the release of AVP within the dorsal hippocampus is stimulated during parturition (18), and AVP-R binding is increased within the MPOA in lactation (Fig. 2D).…”
Section: Discussionmentioning
confidence: 98%
“…So far, any direct involvement of AVP in regulating maternal behavior, one of the most important prosocial behaviors found in mammals, is largely unknown (1,15). However, there is substantial evidence for significant activation of the brain AVP system around parturition and in lactation (16)(17)(18)(19)(20), which has mainly been discussed, to date, in the context of osmotic homeostasis maintenance (1,16,18). Interestingly, central infusion of AVP (21) or of an AVP receptor antagonist (AVP-A) altered the onset of maternal behavior (22), interpreted to be due to actions on oxytocin (OXT) receptors (OXT-Rs) (22), and affected maternal memor y (23), respectively.…”
mentioning
confidence: 99%
“…For example, vasopressin-ir fibers in the lateral septum are more intensely stained in pregnant than in nonpregnant guinea pigs (Merker et al 1980). In addition, the lateral habenular nucleus contains higher levels of assayable vasopressin in lactating than in pregnant rats (Caldwell et al 1987), and the release of vasopressin from the septum is markedly higher in pregnant and parturient, than in sexually naive, female rats (Landgraf et al 1991). These results suggest that vasopressin-ir projections of the BNST and MeA are involved in behaviors or functions that change in pregnant and parturient rats, such as maternal behavior, which is altered by icv injections of vasopressin (Pedersen et al 1982).…”
Section: Orchestration Of Steroid-responsive Functionsmentioning
confidence: 99%