Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine

Meyer‐Lindenberg, Andreas; Domes, Gregor; Kirsch, Peter; Heinrichs, Markus

doi:10.1038/nrn3044

Cited by 1,514 publications

(1,253 citation statements)

References 185 publications

Supporting

Mentioning

1,164

Contrasting

Unclassified

Order By: Relevance

“…Magnocellular neurons of the hypothalamic paraventricular nucleus (PVN) and the supraoptic nucleus , the primary sources of OT synthesis, project to the posterior pituitary, where OT is stored in large secretory vesicles, so-called large dense-core vesicles . In response to calcium influx as well as intracellular calcium release from the endoplasmic reticulum, OT is released into systemic circulation (Meyer-Lindenberg et al, 2011) from axonal terminals within the neurohypophysis (Ludwig and Leng, 2006; Ludwig et al, 2002). The most prominent peripheral OT effects via the classical hypothalamic-neurohypophyseal pathway are the induction of parturition through increased contractibility of the uterine smooth muscles and milk ejection from the mammary gland in response to suckling stimuli in lactating females (Lee et al, 2009).…”

Section: Ot and Early-life Stress (Els) – Role In Shaping Neural Cmentioning

confidence: 99%

“…OT has gained considerable attention in studies of human social behaviors (Lee et al, 2009), including parenting (Bakermans-Kranenburg and van Ijzendoorn, 2008; Gordon et al, 2010; Lee et al, 2009; Meyer-Lindenberg et al, 2011) and attachment formation (Levine et al, 2007). Interestingly, there is evidence that ELS is associated with lower OT concentrations in the cerebrospinal fluid (CSF) of adult women (Heim et al, 2009) and non-human primates (Winslow et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Toepfer

Heim

Entringer

et al. 2017

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

Severe stress in early life, such as childhood abuse and neglect, constitutes a major risk factor in the etiology of psychiatric disorders and somatic diseases. Importantly, these long-term effects may impact the next generation. The intergenerational transmission of maternal early life stress (ELS) may occur via pre-and postnatal pathways, such as alterations in maternal-fetal-placental stress physiology, maternal depression during pregnancy and postpartum, as well as impaired mother-offspring interactions. The neuropeptide oxytocin (OT) has gained considerable attention for its role in modulating all of these assumed transmission pathways. Moreover, central and peripheral OT signaling pathways are highly sensitive to environmental exposures and may be compromised by ELS with implications for these putative transmission mechanisms. Together, these data suggest that OT pathways play an important role in the intergenerational transmission of maternal ELS in humans. By integrating recent studies on gene-environment interactions and epigenetic modifications in OT pathway genes, the present review aims to develop a conceptual framework of intergenerational transmission of maternal ELS that emphasizes the role of OT.

show abstract

Section: Ot and Early-life Stress (Els) – Role In Shaping Neural Cmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Toepfer

Heim

Entringer

et al. 2017

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

show abstract

“…Die CRF-Neurone in der Amygdala besitzen Glucocorticoidrezeptoren, weshalb sie möglicherweise zusätzlich durch die Nebennierenrinde mittels einer Rückkoppelungs-schleife moduliert werden [16]. Furcht (Reaktion auf bestimmte Reize) und Angst (im Sinne eines Zustandes; ungerichtet) werden maßgeblich über die 2 Oxytocin und die suchterhaltenden Mechanismen der Alkoholabhängigkeit K review Amygdala vermittelt und reguliert [16][17][18][19][20][21]. Furchtund angstrelevante neuronale Efferenzen entspringen den zentralen [22], lateralen und basolateralen (basalen) Kerngebieten der Amygdala [17,19].…”

Section: Amygdala Und Crf Bei Suchtunclassified

“…Die Amygdala konnte in fMRI-Studien als einer der Kernpunkte der Oxytocinwirkung eingegrenzt werden [17]. Die anxiolytische Wirkung von Oxytocin in der Amygdala läuft wie im PVN ebenfalls über Interneurone ab [36].…”

Section: Oxytocin Und Amygdalaunclassified

Oxytocin und die suchterhaltenden Mechanismen der Alkoholabhängigkeit

2017

View full text Add to dashboard Cite

Oxytocin and the mechanisms of alcohol dependenceSummary One of the crucial purposes of treating alcohol-dependent patients is to enhance their ability to stay abstinent after detoxification therapy. Anxiety and stress vulnerability are the main factors provoking alcohol craving and relapse. In the first months of abstinence, alcohol-dependent patients frequently show sleep disturbances, irritability and depression, indicating chronic activation of stress pathways. In addition, the loss of confidence in interpersonal interactions results in social withdrawal and reduced willingness to participate in therapeutic programs. Current research shows that the peptide hormone oxytocin exerts substantial anxiolytic effects and facilitates prosocial behavior. Oxytocin can be safely ap-K

show abstract

“…2011). Decreased levels of OXT have been reported in several neuropsychiatric disorders including autism, schizophrenia and major depression (Modahl et al .…”

Section: Gpcr Modulation: a Brief Overviewmentioning

confidence: 99%

Regulation of neuronal chloride homeostasis by neuromodulators

Mahadevan

Woodin

2016

The Journal of Physiology

View full text Add to dashboard Cite

KCC2 is the central regulator of neuronal Cl− homeostasis, and is critical for enabling strong hyperpolarizing synaptic inhibition in the mature brain. KCC2 hypofunction results in decreased inhibition and increased network hyperexcitability that underlies numerous disease states including epilepsy, neuropathic pain and neuropsychiatric disorders. The current holy grail of KCC2 biology is to identify how we can rescue KCC2 hypofunction in order to restore physiological levels of synaptic inhibition and neuronal network activity. It is becoming increasingly clear that diverse cellular signals regulate KCC2 surface expression and function including neurotransmitters and neuromodulators. In the present review we explore the existing evidence that G‐protein‐coupled receptor (GPCR) signalling can regulate KCC2 activity in numerous regions of the nervous system including the hypothalamus, hippocampus and spinal cord. We present key evidence from the literature suggesting that GPCR signalling is a conserved mechanism for regulating chloride homeostasis. This evidence includes: (1) the activation of group 1 metabotropic glutamate receptors and metabotropic Zn2+ receptors strengthens GABAergic inhibition in CA3 pyramidal neurons through a regulation of KCC2; (2) activation of the 5‐hydroxytryptamine type 2A serotonin receptors upregulates KCC2 cell surface expression and function, restores endogenous inhibition in motoneurons, and reduces spasticity in rats; and (3) activation of A3A‐type adenosine receptors rescues KCC2 dysfunction and reverses allodynia in a model of neuropathic pain. We propose that GPCR‐signals are novel endogenous Cl− extrusion enhancers that may regulate KCC2 function.

show abstract

Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine

Cited by 1,514 publications

References 185 publications

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Oxytocin und die suchterhaltenden Mechanismen der Alkoholabhängigkeit

Regulation of neuronal chloride homeostasis by neuromodulators

Contact Info

Product

Resources

About