Oxytocin detection at ppt level in human saliva by an extended-gate-type organic field-effect transistor

Ohshiro, Kohei; Sasaki, Yoko; Zhou, Qi; Lyu, Xiaojun; Yamanashi, Yusuke; Nakahara, K.; Nagaoka, Hirokazu; Minami, Tsuyoshi

doi:10.1039/d1an02188e

Cited by 16 publications

(10 citation statements)

References 48 publications

(54 reference statements)

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“…Saliva is an important and reliable non-invasive test [ 158 , 169 ]. An extended-gate-type OFET sensor was reported for oxytocin.…”

Section: Applications Of the Flexible Ofets-based Sensorsmentioning

confidence: 99%

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Flexible organic field-effect transistors-based biosensors: progress and perspectives

Zhang

et al. 2023

Anal Bioanal Chem

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Organic field-effect transistors (OFETs) have been proposed beyond three decades while becoming a research hotspot again in recent years because of the fast development of flexible electronics. Many novel flexible OFETs-based devices have been reported in these years. Among these devices, flexible OFETs-based sensors made great strides because of the extraordinary sensing capability of FET. Most of these flexible OFETs-based sensors were designed for biological applications due to the advantages of flexibility, reduced complexity, and lightweight. This paper reviews the materials, fabrications, and applications of flexible OFETs-based biosensors. Besides, the challenges and opportunities of the flexible OFETs-based biosensors are also discussed. Graphical abstract

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“…Saliva is an important and reliable non-invasive test [ 158 , 169 ]. An extended-gate-type OFET sensor was reported for oxytocin.…”

Section: Applications Of the Flexible Ofets-based Sensorsmentioning

confidence: 99%

“…An extended-gate-type OFET sensor was reported for oxytocin. The fabricated OFET-based immunosensor has successfully detected oxytocin at a ppt level in human saliva with high recovery rates (96–102%) [ 158 ].…”

Section: Applications Of the Flexible Ofets-based Sensorsmentioning

confidence: 99%

Flexible organic field-effect transistors-based biosensors: progress and perspectives

Zhang

et al. 2023

Anal Bioanal Chem

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“…[43] The approach to control the orientation of recognition scaffolds on the electrode was applied to the selective detection of a hormone showing a complicated chemical structure in human saliva using an extended-gate-type OFET. [46] The target oxytocin comprising nine amino acid residues plays an important role in biological systems as a neurotransmitter. [47] Significant roles of oxytocin including an age-specific circulating hormone, [48] an anabolic bone hormone, [49] and medicine for chronic abdominal pain in peripheral tissue [50] have been reported, indicating that oxytocin is an essential biomarker.…”

Section: Selective Detection Using Ofet-based Immunoassaymentioning

confidence: 99%

mentioning

confidence: 99%

Organic Transistor–Based Chemical Sensors for Real‐Sample Analysis

Sasaki

Minami

2023

Physica Status Solidi (a)

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An organic field‐effect transistor (OFET) is the representative amplification device showing a switching profile by applying a gate voltage, which indicates the potential as a chemical sensor device in combination with appropriate molecular recognition materials. On the other hand, the realization of OFET‐based chemical sensors for real‐sample analysis has been limited owing to the instability of organic semiconductive materials under ambient conditions and the difficulty of the designs of molecular recognition materials. Herein, this Review describes methodologies and actual approaches to maximize the potential of the OFETs as chemical sensor platforms based on fusion technologies between organic electronics and molecular recognition chemistry.This article is protected by copyright. All rights reserved.

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“…Rather than the above-revisited nanostructures in organic materials, efforts to perform structural engineering at a device level were also made. In 2022, Minami et al reported oxytocin detection at pg·mL −1 (part per trillion level) using an extended-gate structure with OFETs [ 66 ]. An anti-oxytocin antibody-attached self-assembled monolayer (SAM) was used in their devices; modified streptavidin on SAM was applied to immobilize biotinylated anti-oxytocin antibodies via biotin-avidin interaction.…”

Section: Device Structurementioning

confidence: 99%

New Opportunities for Organic Semiconducting Polymers in Biomedical Applications

2022

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The life expectancy of humans has been significantly elevated due to advancements in medical knowledge and skills over the past few decades. Although a lot of knowledge and skills are disseminated to the general public, electronic devices that quantitatively diagnose one’s own body condition still require specialized semiconductor devices which are huge and not portable. In this regard, semiconductor materials that are lightweight and have low power consumption and high performance should be developed with low cost for mass production. Organic semiconductors are one of the promising materials in biomedical applications due to their functionalities, solution-processability and excellent mechanical properties in terms of flexibility. In this review, we discuss organic semiconductor materials that are widely utilized in biomedical devices. Some advantageous and unique properties of organic semiconductors compared to inorganic semiconductors are reviewed. By critically assessing the fabrication process and device structures in organic-based biomedical devices, the potential merits and future aspects of the organic biomedical devices are pinpointed compared to inorganic devices.

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Oxytocin detection at ppt level in human saliva by an extended-gate-type organic field-effect transistor

Abstract: Herein, we report an extended-gate-type organic field-effect transistor (OFET) sensor for oxytocin. The fabricated OFET-based immunosensor has successfully detected oxytocin at ppt levels in human saliva with high recovery rates...

Cited by 16 publications

References 48 publications

Flexible organic field-effect transistors-based biosensors: progress and perspectives

Flexible organic field-effect transistors-based biosensors: progress and perspectives

Organic Transistor–Based Chemical Sensors for Real‐Sample Analysis

New Opportunities for Organic Semiconducting Polymers in Biomedical Applications

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