Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward

Bradley, Ellen; Woolley, Joshua

doi:10.1016/j.neubiorev.2017.05.007

Cited by 76 publications

(72 citation statements)

References 271 publications

(377 reference statements)

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“…Further, there have been several treatment efforts targeting cognition that have been applied to substance abuse in dual diagnosis populations. Pharmacological treatments aimed at cognition and social cognition have been disappointing, 29,30 and so herein we focus on Computerized Cognitive Training (CCT) and Computerized Social-Cognitive Training (CSCT). An overview of the CCT and CSCT evaluation studies that we discuss is presented in Table 1.…”

Section: Interventions Targeting Cognitive and Social-cognitive Deficitsmentioning

confidence: 99%

Neurocognition and social cognition training as treatments for violence and aggression in people with severe mental illness

Jones

Harvey

2019

CNS Spectr.

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Aggressive and violent behavior, including both verbal and physical aggression, have considerable adverse consequences for people with schizophrenia. There are several potential causes of violent behavior on the part of people with severe mental illness, which include intellectual impairments, cognitive and social-cognitive deficits, skills deficits, substance abuse, antisocial features, and specific psychotic features. This review explores the interventions that have been tested to this date. Computerized Cognitive Training (CCT) or Computerized Social-Cognitive Training (CSCT) have been associated with reductions in violence. Combined CCT and CSCT have been found to improve social cognition and neurocognition, as well as everyday functioning when combined with rehabilitation interventions. These interventions have been shown to reduce violence in schizophrenia patients across multiple environments, including forensic settings. The reductions in violence and aggression have manifested in various ways, including reduced violent thinking and behavior, reduced physical and violent assaults, and reduced disruptive and aggressive behaviors. Effects of cognitive training may be associated with improvements in problem-solving and the increased ability to deploy alternative strategies. The effect of social cognition training on violence reduction appears to be direct, with improvements in violence related to the extent of improvement in social cognition. There are still remaining issues to be addressed in the use of CCT and CSCT, and the benefits should not be overstated; however, the results of these interventions are very promising.

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Section: Interventions Targeting Cognitive and Social-cognitive Deficitsmentioning

confidence: 99%

Neurocognition and social cognition training as treatments for violence and aggression in people with severe mental illness

Jones

Harvey

2019

CNS Spectr.

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“…Currently, oxytocin is considered as a potential neuropeptide to improve social communication [123,124], the ability to understand other people's feeling [14], autism Neuroendocrinology 2018;107:91-104 DOI: 10.1159/000489263 [17], and schizophrenia [18] in humans. In addition, obesity prevention is expected in future through the use of oxytocin treatment.…”

Section: Clinical Implications Of Oxytocinmentioning

confidence: 99%

“…However, recent studies have discovered its new physiological functions, which include increased trust in humans [7,8], change of paternal and maternal behavior toward their children [9][10][11], increase in pair bonding [12,13], and an increased ability to understand other people's feelings or improvement of social communication [14][15][16]. In addition, there are many articles related to the role of oxytocin in psychiatric diseases [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

The Anorexigenic Neural Pathways of Oxytocin and Their Clinical Implication

et al. 2018

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Oxytocin was discovered in 1906 as a peptide that promotes delivery and milk ejection; however, its additional physiological functions were determined 100 years later. Many recent articles have reported newly discovered effects of oxytocin on social communication, bonding, reward-related behavior, adipose tissue, and muscle and food intake regulation. Because oxytocin neurons project to various regions in the brain that contribute to both feeding reward (hedonic feeding) and the regulation of energy balance (homeostatic feeding), the mechanisms of oxytocin on food intake regulation are complicated and largely unknown. Oxytocin neurons in the paraventricular nucleus (PVN) receive neural projections from the arcuate nucleus (ARC), which is an important center for feeding regulation. On the other hand, these neurons in the PVN and supraoptic nucleus project to the ARC. PVN oxytocin neurons also project to the brain stem and the reward-related limbic system. In addition to this, oxytocin induces lipolysis and decreases fat mass. However, these effects in feeding and adipose tissue are known to be dependent on body weight (BW). Oxytocin treatment is more effective in food intake regulation and fat mass decline for individuals with leptin resistance and higher BW, but is known to be less effective in individuals with normal BW. In this review, we present in detail the recent findings on the physiological role of oxytocin in feeding regulation and the anorexigenic neural pathway of oxytocin neurons, as well as the advantage of oxytocin usage for anti-obesity treatment.

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“…43 Moreover, OT regulates the way in which individuals process emotional information 44 and, in turn, facilitates the identification of emotions 45 ; as such OT may be implicated in many mental health disorders. Altered OT concentrations or responses are evident in patients with postnatal depression, 46 schizophrenia, 47 autism spectrum disorder (ASD) 48 and attention-deficit hyperactivity disorder. 49 Given OT's pivotal role in adaptive social behaviour, studies have investigated the potential therapeutic role of OT administration in improving characteristic behavioural symptoms associated with these disorders.…”

Section: Psycholog Ic Al Effec Tsmentioning

confidence: 99%

Oxytocin therapy in hypopituitarism: Challenges and opportunities

Bhargava

Daughters

Rees

2018

Clinical Endocrinology

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Summary Patients with hypopituitarism display impaired quality of life and excess morbidity and mortality, despite apparently optimal pituitary hormone replacement. Oxytocin is a neuropeptide synthesized in the anterior hypothalamus which plays an important role in controlling social and emotional behaviour, body weight and metabolism. Recent studies have suggested that a deficiency of oxytocin may be evident in patients with hypopituitarism and craniopharyngioma, and that this may be associated with deficits in cognitive empathy. Preliminary data hint at potential benefits of oxytocin therapy in improving these deficits and the accompanying metabolic disturbances that are common in these conditions. However, several challenges remain, including an incomplete understanding of the regulation and mechanisms of action of oxytocin, difficulties in accurately measuring oxytocin levels and in establishing a diagnosis of oxytocin deficiency, and a need to determine both the optimal mode of administration for oxytocin therapy and an acceptable safety profile with long‐term use. This review considers the data linking oxytocin to the neuropsychological and metabolic disturbances evident in patients with craniopharyngioma and hypopituitarism, and describes the challenges that need to be overcome before replacement therapy can be considered as a therapeutic option in clinical practice.

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Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward

Cited by 76 publications

References 271 publications

Neurocognition and social cognition training as treatments for violence and aggression in people with severe mental illness

Neurocognition and social cognition training as treatments for violence and aggression in people with severe mental illness

The Anorexigenic Neural Pathways of Oxytocin and Their Clinical Implication

Oxytocin therapy in hypopituitarism: Challenges and opportunities

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