Oxytocin enhances the expression of morphine-induced conditioned place preference in rats

Moaddab, Mahsa; Hyland, Brian I.; Brown, Colin H.

doi:10.1016/j.psyneuen.2015.01.003

Cited by 38 publications

(23 citation statements)

References 73 publications

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“…OT also reduces the acquisition , not expression of METH-induced CPP (52) which is opposite to that reported with morphine (65). This suggests that OT interferes with the rewarding effect of METH and less to inhibit memory retrieval processes.…”

Section: Evidence That Ot Is Involved In the Response To Drugs Of contrasting

confidence: 72%

“…During morphine withdrawal there was a rebound hyperexcitation of OT cells with increased release of OT (66). After conditioning with repeated injections of morphine, administration of OT may signal a withdrawal state, resulting perhaps in the increased CPP reported in this study(65). In contrast, to these results, Zanos and colleagues (37) report that the OT analogue, carbetocin, given peripherally, inhibited the development of anxiety and depressive behaviors during morphine withdrawal in addition to improving social behaviors.…”

Section: Evidence That Ot Is Involved In the Response To Drugs Of mentioning

confidence: 79%

“…For self-administration of opiates, unlike ethanol, OT reduces self-administration only if tolerance is present (63). The effect of OT on CPP is inconsistent across substances: there is a decrease in acquisition of the conditioned behavior for ethanol (53) and psychostimulants (52) but no effect for morphine (65). OT seems to increase the expression of CPP when administered after the acquisition of CPP has been established.…”

Section: Discussionmentioning

confidence: 99%

“…In a more recent study, OT administered ICV resulted in an increase in expression of morphine-induced CPP, with no effect on its acquisition (65). Morphine administration has been shown to acutely inhibit OT cell firing in the hypothalamus and repeated administration of morphine results in tolerance to this effect(66).…”

Section: Evidence That Ot Is Involved In the Response To Drugs Of mentioning

confidence: 99%

See 3 more Smart Citations

Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date

et al. 2016

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The neuropeptide oxytocin plays a role in reward, stress, social affiliation, learning and memory processes. As such there is increasing interest in oxytocin as a potential treatment for addictions. The oxytocin system is itself altered by acute or chronic exposure to drugs of abuse. A large number of preclinical studies in rodents have investigated the effect of oxytocin on various drug-induced behaviors to determine whether oxytocin can reverse the neuroadaptations occurring with repeated drug and alcohol use. In addition, the mechanisms by which oxytocin acts to modify the behavioral response to drugs of abuse are beginning to be understood. More recently, a few small clinical studies have been conducted in cocaine, cannabis and alcohol dependence. This review summarizes the preclinical as well as clinical literature to date on the oxytocin system and its relevance to drug and alcohol addiction.

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Section: Evidence That Ot Is Involved In the Response To Drugs Of contrasting

confidence: 72%

Section: Evidence That Ot Is Involved In the Response To Drugs Of mentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Evidence That Ot Is Involved In the Response To Drugs Of mentioning

confidence: 99%

See 2 more Smart Citations

Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date

et al. 2016

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“…In the NAc, there is a simultaneous interaction of DA and OT during the formation of partner preferences, since blockade of either receptor with infusions of antagonists prevents the development of pairbonds induced by copulation (Liu & Wang, 2003; Young, Lim, Gingrich, & Insel, 2001). Interestingly, OT also mediates the rewarding experience induced by opioids (Moaddab, Hyland, & Brown, 2015), such that under the effects of OT, animals are more likely to display opioid-induced past learning. Indeed, in many studies, it has been argued that it is not the intensity of an orgasm that modulates the probability of development of a pair bond but rather the natural expression of OT, AVP, and D2 receptors in those brain circuits (i.e.…”

Section: Neural Pathways That Mediate Orgasm-induced Partner Preferencesmentioning

confidence: 99%

The role of orgasm in the development and shaping of partner preferences

Coria-Ávila

Herrera-Covarrubias

Ismail

et al. 2016

Socioaffective Neuroscience & Psychology

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BackgroundThe effect of orgasm on the development and shaping of partner preferences may involve a catalysis of the neurochemical mechanisms of bonding. Therefore, understanding such process is relevant for neuroscience and psychology.MethodsA systematic review was carried out using the terms Orgasm, Sexual Reward, Partner Preference, Pair Bonding, Brain, Learning, Sex, Copulation.ResultsIn humans, concentrations of arousing neurotransmitters and potential bonding neurotransmitters increase during orgasm in the cerebrospinal fluid and the bloodstream. Similarly, studies in animals indicate that those neurotransmitters (noradrenaline, oxytocin, prolactin) and others (e.g. dopamine, opioids, serotonin) modulate the appetitive and consummatory phases of sexual behavior and reward. This suggests a link between the experience of orgasm/sexual reward and the neurochemical mechanisms of pair bonding. Orgasm/reward functions as an unconditioned stimulus (UCS). Some areas in the nervous system function as UCS-detection centers, which become activated during orgasm. Partner-related cues function as conditioned stimuli (CS) and are processed in CS-detector centers.ConclusionsThroughout the article, we discuss how UCS- and CS-detection centers must interact to facilitate memory consolidation and produce recognition and motivation during future social encounters.

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Magnocellular Neurons and Posterior Pituitary Function

Brown

2016

Comprehensive Physiology

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The posterior pituitary gland secretes oxytocin and vasopressin (the antidiuretic hormone) into the blood system. Oxytocin is required for normal delivery of the young and for delivery of milk to the young during lactation. Vasopressin increases water reabsorption in the kidney to maintain body fluid balance and causes vasoconstriction to increase blood pressure. Oxytocin and vasopressin secretion occurs from the axon terminals of magnocellular neurons whose cell bodies are principally found in the hypothalamic supraoptic nucleus and paraventricular nucleus. The physiological functions of oxytocin and vasopressin depend on their secretion, which is principally determined by the pattern of action potentials initiated at the cell bodies. Appropriate secretion of oxytocin and vasopressin to meet the challenges of changing physiological conditions relies mainly on integration of afferent information on reproductive, osmotic, and cardiovascular status with local regulation of magnocellular neurons by glia as well as intrinsic regulation by the magnocellular neurons themselves. This review focuses on the control of magnocellular neuron activity with a particular emphasis on their regulation by reproductive function, body fluid balance, and cardiovascular status. © 2016 American Physiological Society. Compr Physiol 6:1701-1741, 2016.

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Oxytocin enhances the expression of morphine-induced conditioned place preference in rats

Cited by 38 publications

References 73 publications

Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date

Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date

The role of orgasm in the development and shaping of partner preferences

Magnocellular Neurons and Posterior Pituitary Function

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