Oxytocin Exerts Antidepressant-like effect by potentiating dopaminergic synaptic transmission in the mPFC

Li, Qian; Zhang, Bing; Cao, Hang; Liu, Wei; Guo, Fei; Shen, Fei; Ye, Binglu; Liu, Huan; Li, Yang; Liu, Zhiqiang

doi:10.1016/j.neuropharm.2019.107836

Cited by 31 publications

(15 citation statements)

References 72 publications

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“…Under traumatic conditions, the functions of oxytocin may allow a shift to those necessary for protection of the survival of cortical processing. However, when oxygen is insufficient, psychologic dissociation ( Li et al, 2020 ) or even loss of consciousness can occur ( Carter, 2014 ). As one example, oxytocin levels were exceptionally high in women with a history of trauma who showed a pattern of dissociation, supporting the hypothesis that elevations in oxytocin can be adaptive in trauma ( Seng et al, 2013 ).…”

Section: Oxytocin and “Stress Coping”mentioning

confidence: 99%

Is Oxytocin “Nature’s Medicine”?

et al. 2020

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Section: Oxytocin and “Stress Coping”mentioning

confidence: 99%

Is Oxytocin “Nature’s Medicine”?

et al. 2020

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“…Several researchers have espoused a sociobiological theory that group music triggers the neurohormonal systems associated with social bonding, including, but not limited to, the oxytocinergic system (Harvey, 2020; Mallik et al, 2017). Oxytocin has been considered a key candidate underpinning the development and maintenance of social bonds (Crockford et al, 2014) and has been associated with improved mood states (Li et al, 2020).…”

Section: The Social Bonding Accountmentioning

confidence: 99%

Changes in mood, oxytocin, and cortisol following group and individual singing: A pilot study

Good

Russo

2021

Psychology of Music

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Group singing elevates mood, increases social bonding, and regulates stress. However, the question remains as to how much of the singer’s mood-boost is derived from social aspects of group singing and how much can be achieved through singing alone. In the current study, we adopted a sociobiological approach to investigate the underpinnings of the mood-boosting effect of singing. Using a within-subjects design, self-report mood, salivary oxytocin, and salivary cortisol were assessed before and after group and individual singing conditions. This study uncovered several important findings: group singing elevated mood, whereas individual singing did not. Importantly, although both group and individual singing led to decreases in cortisol, only group singing led to increases in oxytocin. Further analysis revealed that oxytocin, but not cortisol, significantly correlated with mood. These findings suggest that the mood-boosting effect of singing is likely due to social aspects and is influenced by changes in oxytocin.

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“…As the working alliance is considered the most robust predictor of therapy outcome ( 21 ), one potential hypothesis that can be made is that OT affects the outcome indirectly through the facilitation of the therapeutic process. Nonetheless, it should be acknowledged that studies also suggest that OT has an antidepressant-like effect, and can therefore have a direct effect on the reduction in depressive symptoms ( 22 , 23 ). It has also been suggested that symptomatic improvements often observed in IN-OT clinical trials may be attributed to improvements in social functioning ( 24 ), social cognition ( 25 ), and theory of mind ( 7 , 26 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Oxytocin and Its Association With Psychotherapy Process and Outcome

et al. 2021

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The potential of Oxytocin (OT) as a facilitator of psychotherapy has been previously acknowledged, nonetheless, randomized controlled trials thus far have not yielded conclusive results. One approach suggested to clarify empirical inconsistencies is to refine the study hypotheses and data collection process by utilizing an in-depth idiographic exploration of the investigated phenomena. In this case illustration we provide an in-depth analysis comparing two patients hospitalized in a closed psychiatric ward with depression and undergoing psychotherapy twice a week. These two patients were randomly allocated to receive either OT or placebo, twice a day for a period of 4 weeks. Both patients completed longitudinal assessments of process and outcome measures, and therapists' clinical notes were extracted and reviewed. Reliable clinical change was calculated for all outcome and process measures. The results indicated that the patient receiving OT showed significant improvement in interpersonal distress, as well as in anxiety and depression symptoms, while the placebo patient showed no significant change during the study period. Furthermore, while both patients showed no significant changes in the therapeutic alliance ratings, the therapist of the OT patient regularly reported positive changes in alliance in the medical notes, while no such report was observed in the placebo patient. These results suggest that changes produced by OT administration may be more noticeable by the therapist. Implications for future studies aimed at assessing the effect of OT on psychotherapy process and outcome are discussed.

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Oxytocin Exerts Antidepressant-like effect by potentiating dopaminergic synaptic transmission in the mPFC

Cited by 31 publications

References 72 publications

Is Oxytocin “Nature’s Medicine”?

Is Oxytocin “Nature’s Medicine”?

Changes in mood, oxytocin, and cortisol following group and individual singing: A pilot study

Case Report: Oxytocin and Its Association With Psychotherapy Process and Outcome

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