➢ Delayed diagnosis and improper management of upper-extremity extravasation events result in long-term sequelae and are the basis of many medical litigation cases in the United States.➢ The extent of the injury resulting from an extravasation event depends on the toxicity of the agent, the volume extravasated, and the time to identify the event and to initiate intervention.➢ Timely intervention can prevent long-term sequelae such as contractures, complex regional pain syndrome, and neuromuscular deficits.