2014
DOI: 10.1016/j.ejphar.2014.07.053
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Oxytocin has therapeutic effects on cancer, a hypothesis

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Cited by 41 publications
(46 citation statements)
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“…Childbearing, particularly at a younger age, has been shown consistently to reduce the risk of breast cancer in the long term [12]. Oxytocin is a growth regulator in neoplastic pathology inhibiting proliferation of neoplastic cells of either epithelial (-mammary and endometrial), nervous or bone origin in vitro, as well as mouse and rat mammary carcinomas in vivo [7,8]. On the contrary, in neoplastic cells derived from trophoblast and endothelium, oxytocin was found to promote cell proliferation [7,8].…”
Section: Discussionmentioning
confidence: 94%
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“…Childbearing, particularly at a younger age, has been shown consistently to reduce the risk of breast cancer in the long term [12]. Oxytocin is a growth regulator in neoplastic pathology inhibiting proliferation of neoplastic cells of either epithelial (-mammary and endometrial), nervous or bone origin in vitro, as well as mouse and rat mammary carcinomas in vivo [7,8]. On the contrary, in neoplastic cells derived from trophoblast and endothelium, oxytocin was found to promote cell proliferation [7,8].…”
Section: Discussionmentioning
confidence: 94%
“…Oxytocin plays a role also as a growth regulator in neoplastic pathology [7]. In a review, oxytocin was raised as having therapeutic effects on cancer [8]. Further, experimental in vitro studies on human cancer cell lines have shown an inhibitory effect of oxytocin on cancer cell growth [8].…”
Section: Introductionmentioning
confidence: 98%
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“…These findings have driven a hypothesis that oxytocin may have therapeutic effects on cancer [28]. Similarly, Misra et al (2012) reported that females with greater parity may reduce their long-term BCa risk because of multiple hormones released during pregnancy that generate genetic changes in the mammary glands which decrease BCa risk in mature breast cells [31].…”
Section: Discussionmentioning
confidence: 99%
“…The prevalent interpretation that greater birth rate protects against female BCa [26] is that the interruption in the normal menstrual cycle during pregnancy and subsequent breast feeding is associated with an interruption in the normal cyclical production of oestrogen [27], but an increase in oxytocin [28]. The public have been extensively educated for decades that oestrogen contributes to BCa as it fuels the growth of most breast cancer tumours [19].…”
Section: Discussionmentioning
confidence: 99%