Oxytocin in diabetic Covid-19 patients: a new perspective

Al-Kuraishy, Hayder M; Al-Gareeb, Ali I; Eldahshan, Omayma A.; Batiha, Gaber El‐Saber

doi:10.1080/14786419.2022.2124410

Cited by 5 publications

(8 citation statements)

References 7 publications

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“…As well, oxytocin has anti‐inflammatory and antioxidant effects, thereby attenuating T2DM‐mediated complications. 67 A review study suggested that LCZ696 can enhance insulin sensitivity and glucose homeostasis by increasing oxytocin serum levels. 68 In this state, augmentation of oxytocin levels by NEP inhibitors could be a new therapeutic strategy in the management of T2DM.…”

Section: Nep Inhibitors and Glucose Homeostasismentioning

confidence: 99%

“…Oxytocin activates peripheral glucose uptake and reduces IR in mice 66 . Al‐kuraishy et al 67 illustrated that oxytocin was superior to GLP‐1 in the management of T2DM in COVID‐19 patients. As well, oxytocin has anti‐inflammatory and antioxidant effects, thereby attenuating T2DM‐mediated complications 67 .…”

Section: Nep Inhibitors and Glucose Homeostasismentioning

confidence: 99%

“…Al‐kuraishy et al 67 illustrated that oxytocin was superior to GLP‐1 in the management of T2DM in COVID‐19 patients. As well, oxytocin has anti‐inflammatory and antioxidant effects, thereby attenuating T2DM‐mediated complications 67 . A review study suggested that LCZ696 can enhance insulin sensitivity and glucose homeostasis by increasing oxytocin serum levels 68 .…”

Section: Nep Inhibitors and Glucose Homeostasismentioning

confidence: 99%

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Effects of neprilysin and neprilysin inhibitors on glucose homeostasis: Controversial points and a promising arena

Alanazi

Al-Kuraishy

Al-Gareeb

et al. 2023

Journal of Diabetes

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Neprilysin (NEP) is a transmembrane zinc‐dependent metalloproteinase that inactivates various peptide hormones including glucagon‐like peptide 1 (GLP‐1). NEP inhibitors may be effective in the management of type 2 diabetes mellitus (T2DM) by increasing the circulating level of GLP‐1. However, acute‐effect NEP inhibitors may lead to detrimental effects by increasing blood glucose independent of GLP‐1. These findings suggest a controversial point regarding the potential role of NEP inhibitors on glucose homeostasis in T2DM patients. Therefore, this perspective aimed to clarify the controversial points concerning the role of NEP inhibitors on glucose homeostasis in T2DM. NEP inhibitors may lead to beneficial effects by inhibition of NEP, which is involved in the impairment of glucose homeostasis through modulation of insulin resistance. NEP increases dipeptidyl peptidase‐4 (DPP4) activity and contributes to increasing active GLP‐1 proteolysis so NEP inhibitors may improve glycemic control through increasing endogenous GLP‐1 activity and reduction of DPP4 activity. Thus, NEP inhibitors could be effective alone or in combination with antidiabetic agents in treating T2DM patients. However, long‐term and short‐term effects of NEP inhibitors may lead to a detrimental effect on insulin sensitivity and glucose homeostasis through different mechanisms including augmentation of substrates and pancreatic amyloid deposition. These findings are confirmed in animal but not in humans. In conclusion, NEP inhibitors produce beneficial rather than detrimental effects on glucose homeostasis and insulin sensitivity in humans though most of the detrimental effects of NEP inhibitors are confirmed in animal studies.

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Section: Nep Inhibitors and Glucose Homeostasismentioning

confidence: 99%

Section: Nep Inhibitors and Glucose Homeostasismentioning

confidence: 99%

Section: Nep Inhibitors and Glucose Homeostasismentioning

confidence: 99%

See 1 more Smart Citation

Effects of neprilysin and neprilysin inhibitors on glucose homeostasis: Controversial points and a promising arena

Alanazi

Al-Kuraishy

Al-Gareeb

et al. 2023

Journal of Diabetes

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“…T2DM is a chronic endocrine disorder due to the reduction of insulin sensitivity and relative deficiency of insulin secretion 11 . The development of T2DM is closely linked with overweight, obesity, and increased age 11,80 . Impaired insulin secretion and insulin resistance (IR) are still the core defect in T2DM that is linked to the development of macrovascular and microvascular complications 12,13 .…”

Section: Introductionmentioning

confidence: 99%

“…11 The development of T2DM is closely linked with overweight, obesity, and increased age. 11 , 80 Impaired insulin secretion and insulin resistance (IR) are still the core defect in T2DM that is linked to the development of macrovascular and microvascular complications. 12 , 13 Many pro‐inflammatory/inflammatory cytokines and associated mediators are released from the visceral to control pancreatic β‐cell functions.…”

Section: Introductionmentioning

confidence: 99%

Metformin and growth differentiation factor 15 (GDF15) in type 2 diabetes mellitus: A hidden treasure

Al-Kuraishy

Al-Gareeb

Αλεξίου³

et al. 2022

Journal of Diabetes

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Type 2 diabetes mellitus (T2DM) is a chronic endocrine disorder due to the reduction of insulin sensitivity and relative deficiency of insulin secretion.Growth differentiation factor 15 (GDF15) belongs to the transforming growth factor beta (TGF-β) superfamily and was initially identified as macrophage inhibitory cytokine-1 (MIC-1). GDF15 is considered a cytokine with an anti-inflammatory effect and increases insulin sensitivity, reduces body weight, and improves clinical outcomes in diabetic patients. GDF15 acts through stimulation of glial-derived neurotrophic factor (GDNF) family receptor α-like (GFRAL), which is highly expressed in the brain stem to induce taste aversion. Metformin belongs to the group of biguanides that are derived from the plant Galega officinalis. It is interesting to note that metformin is an insulin-sensitizing agent used as a first-line therapy for T2DM that has been shown to increase the circulating level of GDF15. Thus, the present review aims to determine the critical association of the GDF15 biomarker in T2DM and how metformin agents affect it. This review illustrates that metformin activates GDF15 expression, which reduces appetite and leads to weight loss in both diabetic and nondiabetic patients. However, the present review cannot give a conclusion in this regard. Therefore, experimental,

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SARS-CoV-2 infection and dysregulation of nuclear factor erythroid-2-related factor 2 (Nrf2) pathway

Hamad,

Al-kuraishy,

Alexiou

et al. 2023

Cell Stress and Chaperones

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Coronavirus disease 2019 (COVID-19) is a recent pandemic caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) leading to pulmonary and extra-pulmonary manifestations due to the development of oxidative stress (OS) and hyperinflammation. The underlying cause for OS and hyperinflammation in COVID-19 may be related to the inhibition of nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidative responses and cellular homeostasis. The Nrf2 pathway inhibits the expression of pro-inflammatory cytokines and the development of cytokine storm and OS in COVID-19. Nrf2 activators can attenuate endothelial dysfunction (ED), renin-angiotensin system (RAS) dysregulation, immune thrombosis, and coagulopathy. Hence, this review aimed to reveal the potential role of the Nrf2 pathway and its activators in the management of COVID-19. As well, we tried to revise the mechanistic role of the Nrf2 pathway in COVID-19.

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Oxytocin in diabetic Covid-19 patients: a new perspective

Cited by 5 publications

References 7 publications

Effects of neprilysin and neprilysin inhibitors on glucose homeostasis: Controversial points and a promising arena

Effects of neprilysin and neprilysin inhibitors on glucose homeostasis: Controversial points and a promising arena

Metformin and growth differentiation factor 15 (GDF15) in type 2 diabetes mellitus: A hidden treasure

SARS-CoV-2 infection and dysregulation of nuclear factor erythroid-2-related factor 2 (Nrf2) pathway

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