Oxytocin in survivors of childhood-onset craniopharyngioma

Daubenbüchel, Anna M.; Hoffmann, Anika; Eveslage, Maria; Özyurt, Jale; Lohle, K.; Reichel, Julia; Thiel, Christiane M.; Martens, Henri; Geenen, Vincent; Müller, Hermann L.

doi:10.1007/s12020-016-1084-5

Cited by 56 publications

(53 citation statements)

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“…The most consistent findings in the neuropsychological domain are deficits in learning and episodic memory, largely sparing other memory components, and social‐emotional deficits such as emotional lability and social withdrawal . In the same study cohort, we previously have shown that specific anterior hypothalamic lesions (HL) are associated with decreased oxytocin saliva concentrations (OSC) . First experiences with single intranasal oxytocin administration indicated that oxytocin might have positive effects on emotion perception in CP with anterior HL .…”

Section: Introductionmentioning

confidence: 81%

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Eating behaviour and oxytocin in patients with childhood‐onset craniopharyngioma and different grades of hypothalamic involvement

et al. 2019

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Background: Patients with childhood-onset craniopharyngioma (CP) often suffer from tumour or treatment-related hypothalamic lesions (HL). These lesions may alter production of oxytocin, which plays a major role in the regulation of eating behaviour and body composition.Objective: In CP with different degrees of HL, we investigated associations between HL, eating behaviour/eating attitudes, and oxytocin saliva concentrations (OSC).Methods: In a cross-sectional case-control study on 34 CP and 73 healthy controls, OSC were measured before, and 60 minutes after breakfast by immunoassay. Eating behaviour, attitudes, and habits were assessed by standardized questionnaires.Results: CP with anterior + posterior HL presented with more adverse eating behaviours/symptoms of eating disorders than CP without HL, CP with anterior HL, and controls. Eating behaviour in CP with anterior HL was similar to controls, except for their tendency towards high dietary restraints. Decreases in postprandial compared with fasting OSC were associated with adverse eating behaviour in CP and controls and with higher BMI in CP.Conclusions: CP with anterior HL and CP with anterior + posterior HL present with distinct patterns of eating behaviour. Reduced postprandial compared with fasting OSC is associated with weight problems in CP and with adverse eating behaviour and symptoms of eating disorders in both CP and controls.

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Section: Introductionmentioning

confidence: 81%

“…We quantified changes in OSC before and after breakfast (ΔOSC is defined as the difference in OSC after breakfast and OSC before breakfast). Saliva was collected using a standardized method for saliva sampling as described previously . OSC were measured by immunoassay as described previously …”

Section: Methodsmentioning

confidence: 99%

Eating behaviour and oxytocin in patients with childhood‐onset craniopharyngioma and different grades of hypothalamic involvement

et al. 2019

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“…A 2016 case report highlighted an improvement in pro-social behaviour in response to nasal OT in a boy following surgical treatment of a craniopharyngioma. 60 Daubenbüchel et al 61 Collectively, these data suggest that patients with hypopituitarism may present with a deficiency in OT associated with reduced cognitive empathy, and that this might be amenable to treatment with OT replacement.…”

Section: Ox Y To Cin In Hyp Opitu Itaris Mmentioning

confidence: 97%

“…A 2016 case report highlighted an improvement in pro‐social behaviour in response to nasal OT in a boy following surgical treatment of a craniopharyngioma . Daubenbüchel et al subsequently compared salivary OT concentrations in 34 patients in the German Childhood Craniopharyngioma Registry and 73 healthy volunteers, finding no difference in OT levels between groups. They speculated that this might reflect either preserved hypothalamic function or compensatory secretion by other neuronal pathways, such as the medial preoptic area, striaterminalis and lateral amygdala .…”

Section: Oxytocin In Hypopituitarismmentioning

confidence: 99%

Oxytocin therapy in hypopituitarism: Challenges and opportunities

Bhargava

Daughters

Rees

2018

Clinical Endocrinology

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Summary Patients with hypopituitarism display impaired quality of life and excess morbidity and mortality, despite apparently optimal pituitary hormone replacement. Oxytocin is a neuropeptide synthesized in the anterior hypothalamus which plays an important role in controlling social and emotional behaviour, body weight and metabolism. Recent studies have suggested that a deficiency of oxytocin may be evident in patients with hypopituitarism and craniopharyngioma, and that this may be associated with deficits in cognitive empathy. Preliminary data hint at potential benefits of oxytocin therapy in improving these deficits and the accompanying metabolic disturbances that are common in these conditions. However, several challenges remain, including an incomplete understanding of the regulation and mechanisms of action of oxytocin, difficulties in accurately measuring oxytocin levels and in establishing a diagnosis of oxytocin deficiency, and a need to determine both the optimal mode of administration for oxytocin therapy and an acceptable safety profile with long‐term use. This review considers the data linking oxytocin to the neuropsychological and metabolic disturbances evident in patients with craniopharyngioma and hypopituitarism, and describes the challenges that need to be overcome before replacement therapy can be considered as a therapeutic option in clinical practice.

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“…Previous research has found a high prevalence for social and emotional deficits in this patient group, 34,35 although the underlying cause for the higher rate of such deficits has not been established. Recently, several studies have been able to show that the oxytocin system is impaired in these patients 36‐38 . Importantly, in healthy people, oxytocin increases in different situations such as social stress, sexual stimulation or physical exercise, 5 whereas craniopharyngioma patients cannot release additional oxytocin in response to stimulation 36 .…”

Section: Introductionmentioning

confidence: 99%

Oxytocin release deficit and social cognition in craniopharyngioma patients

Brandi

Gebert

Kopczak

et al. 2020

J Neuroendocrinology

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Oxytocin is a neuropeptide known to affect social behaviour and cognition. Craniopharyngioma patients are considered to have an oxytocin‐release‐deficit caused by a rare tumour affecting the pituitary and/or the hypothalamus relevant for oxytocin production and release. To assess social behaviour and socio‐cognitive abilities in this patient group, we tested 13 patients and 23 healthy controls on self‐report questionnaires and an eye‐tracking paradigm including fast facial emotion recognition. Additionally, saliva oxytocin levels acquired before and after a physical stress induction were available from a previous study, representing the reactivity of the oxytocin system. The data revealed three major results. First, patients with an oxytocin‐release‐deficit scored higher on self‐reported autistic traits and reduced levels of hedonia for social encounters, although they showed no impairments in attributing mental states. Second, patients showed more difficulties in the fast emotion recognition task. Third, although automatic gaze behaviour during emotion recognition did not differ between groups, gaze behaviour was related to the reactivity of the oxytocin system across all participants. Taken together, these findings demonstrate the importance of investigating the reactivity of the oxytocin system and its relationship with social cognition. Our findings suggest that reduced emotional processing abilities may represent a pathological feature in a group of craniopharyngioma patients, indicating that this patient group might benefit from specific treatments within the social domain.

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Oxytocin in survivors of childhood-onset craniopharyngioma

Cited by 56 publications

References 40 publications

Eating behaviour and oxytocin in patients with childhood‐onset craniopharyngioma and different grades of hypothalamic involvement

Eating behaviour and oxytocin in patients with childhood‐onset craniopharyngioma and different grades of hypothalamic involvement

Oxytocin therapy in hypopituitarism: Challenges and opportunities

Oxytocin release deficit and social cognition in craniopharyngioma patients

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