Oxytocin in the Neurohypophysis of the Laying Hen

Tanaka, Katuhide; Nakajo, Seiichi

doi:10.1038/187245a0

Cited by 16 publications

(5 citation statements)

References 3 publications

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“…Munsick et al (1960) has shown that the concentration of AVT in the fowl neurohypophysis is 10 times that of oxytocin and Tanaka and Nakajo (1960;1962) reported a decrease in the AVT content of the neurohypophysis which coincided with oviposition. Douglas and Sturkie (1964) and Lin (1966, 1967) measured AVT in the blood of laying hens and found that the activity of the hormone increased markedly during oviposition.…”

Section: Introductionmentioning

confidence: 96%

Changes in the plasma concentration of immunoreactive arginine vasotocin during oviposition in the domestic fowl

Tanaka¹,

Goto²,

Yoshioka³

et al. 1984

British Poultry Science

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The plasma concentrations of immunoreactive arginine vasotocin (AVT) were measured during oviposition and shortly before ovulation of the first egg (Cl) of a clutch. Immunoreactive AVT was determined on bentonite extracts of 0.5 ml plasma samples using the method of Rosenbloom and Fisher (1974). The R-70 antiserum used to measure AVT cross reacted with arginine vasopressin (AVP), however the fowl pituitary does not synthesise AVP. Over a period of 10 to 90 min before oviposition the plasma AVT concentration was about 20 pg/ml; during oviposition it increased four-fold. Measurements made at frequent intervals showed that plasma AVT concentration increased 5 to 6 min before oviposition, reached a peak during oviposition itself and decreased rapidly in the following 5 to 6 min. The surge in plasma AVT occurred on average 48 min before Cl ovulation.

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Section: Introductionmentioning

confidence: 96%

Changes in the plasma concentration of immunoreactive arginine vasotocin during oviposition in the domestic fowl

Tanaka¹,

Goto²,

Yoshioka³

et al. 1984

British Poultry Science

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“…Electrical lesions or stimulations of the hen hypothalamus (18,19), where neurons concerning the release of neurohypophysial hormones are located, delay or induce oviposition, suggesting that oviposition is controlled by the central nervous system through the release of AVT. At the time of oviposition, AVT is acutely released from the neural lobe of the pituitary, as evidenced by a decrease in the AVT content in the neural lobe (20,21) and a remarkable increase in the plasma AVT concentration (12,(22)(23)(24). However, whether AVT is the trigger for the initiation of contraction of the uterus, resulting in oviposition, is unknown.…”

mentioning

confidence: 99%

Arginine vasotocin receptor binding in the hen uterus (shell gland) before and after oviposition

Takahashi

Kawashima²,

Kamiyoshi³

et al. 1994

European Journal of Endocrinology

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The binding affinity and capacity of arginine vasotocin (AVT) receptor in the hen uterus changed during a period before and after oviposition. Three hours before oviposition, the binding capacity of the AVT receptor increased. An injection of prostaglandin (PG) F2 alpha caused an increase in the AVT receptor Bmax in the uterus, and indomethacin blocked the normal rise in the AVT receptor Bmax and PGF content prior to oviposition. However, just prior to oviposition, the binding affinity increased with a decrease in the binding capacity. A progesterone injection caused an increase in binding affinity and a decrease in binding capacity of the AVT receptor. The specific binding of the progesterone receptor in the uterus increased 2 h before oviposition and remained high until oviposition. Serum AVT levels increased at oviposition. An injection of AVT caused an increase in the affinity of the AVT receptor with a decrease in the capacity. The change in the affinity and capacity of AVT receptor at oviposition may result from the action of progesterone via increased progesterone receptor binding, and the action of AVT on its own receptors.

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“…The contraction of uterine muscle is caused by AVT (Munsick et al, 1960;Rzasa, 1972), presumably through binding to its receptor existing in the uterus (Takahashi et al, 1992;1994a), and oviposition is induced (Rzasa and Ewy, 1970;Taka-hashi and Kawashima, 2003;2008;Takahashi et al, 2004). The concentration of AVT has been detected to decrease in the neurohypophysis (Tanaka and Nakajo, 1960;1962) and the dramatic increase in blood (Douglas and Sturkie, 1964;Tanaka et al, 1984;Rice et al, 1985;Shimada et al, 1986;Koike et al, 1988;Takahashi et al, 1994a;Takahashi and Kawashima, 2008) just after oviposition. The blood concentration of AVT has been reported to be increased by estrogen (Takahashi et al, 1994b) and prostaglandin F 2α (PGF 2α ; Takahashi and Kawashima, 2009a).…”

Section: Introductionmentioning

confidence: 93%

Changes in angiotensin II receptor bindings in the hen neurohypophysis before and after oviposition

et al. 2011

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The present study was performed to elucidate whether the angiotensin II (ANG II) receptor exists in the plasma membrane fraction of the neurohypophysis in hens, to estimate the time of action of ANG II on the neurohypophysis before and after oviposition, and to examine relationships between the action of ANG II on the neurohypophysis and those of estrogen and prostaglandin F(2α) (PGF(2α)) in relation to arginine vasotocin (AVT) release. The specific binding had a binding specificity to chicken ANG II (cANG II), reversibility, and saturation in the [(125)I]cANG II binding assay. Scatchard analysis revealed that the binding sites are of a single class. The equilibrium dissociation constant (K(d)) obtained by kinetic analysis and Scatchard analysis suggested a high affinity, and the maximum binding capacity (B(max)) obtained by Scatchard analysis suggested a limited capacity. These results suggest that an ANG II receptor exists in the neurohypophysis of hens. The K(d) and the B(max) value was significantly smaller in laying hens than in nonlaying hens, which suggests that bindings of the cANG II receptor change, depending on the difference in laying condition. Values of the K(d) and the B(max) decreased approximately 15 min before oviposition in laying hens, and decreased 1 h after an intramuscular injection of estradiol-17β and 5 min after an intravenous injection of cANG II in nonlaying hens. The amount of specific binding of PGF(2α) receptor in the neurohypophysis also decreased and AVT concentration in blood increased after the cANG II injection. It seems likely that the action of cANG II in the neurohypophysis increases due to the effect of estrogen approximately 15 min before oviposition, and the cANG II action stimulates AVT release through the increase in the PGF(2α) action in this tissue.

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Oxytocin in the Neurohypophysis of the Laying Hen

Cited by 16 publications

References 3 publications

Changes in the plasma concentration of immunoreactive arginine vasotocin during oviposition in the domestic fowl

Changes in the plasma concentration of immunoreactive arginine vasotocin during oviposition in the domestic fowl

Arginine vasotocin receptor binding in the hen uterus (shell gland) before and after oviposition

Changes in angiotensin II receptor bindings in the hen neurohypophysis before and after oviposition

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